[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/mst1r-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/mst1r-wikipedia\/","headline":"MST1R – Wikipedia","name":"MST1R – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Macrophage-stimulating protein receptor is a protein that in","datePublished":"2020-05-27","dateModified":"2020-05-27","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/mst1r-wikipedia\/","wordCount":6877,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensMacrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene.[5][6] MST1R is also known as RON (Recepteur d’Origine Nantais) kinase, named after the French city in which it was discovered. It is related to the c-MET receptor tyrosine kinase.[5][7]Interactions[edit]MST1R has been shown to interact with Grb2.[8][9]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000164078 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032584 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b Ronsin C, Muscatelli F, Mattei MG, Breathnach R (May 1993). “A novel putative receptor protein tyrosine kinase of the met family”. Oncogene. 8 (5): 1195\u2013202. PMID\u00a08386824.^ “Entrez Gene: MST1R macrophage stimulating 1 receptor (c-met-related tyrosine kinase)”.^ Gaudino G, Follenzi A, Naldini L, Collesi C, Santoro M, Gallo KA, Godowski PJ, Comoglio PM (August 1994). “RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP”. EMBO J. 13 (15): 3524\u201332. doi:10.1002\/j.1460-2075.1994.tb06659.x. PMC\u00a0395256. PMID\u00a08062829.^ Li BQ, Wang MH, Kung HF, Ronsin C, Breathnach R, Leonard EJ, Kamata T (November 1995). “Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor”. Biochem. Biophys. Res. Commun. 216 (1): 110\u20138. doi:10.1006\/bbrc.1995.2598. PMID\u00a07488076.^ Iwama A, Yamaguchi N, Suda T (November 1996). “STK\/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family”. EMBO J. 15 (21): 5866\u201375. doi:10.1002\/j.1460-2075.1996.tb00973.x. PMC\u00a0452340. PMID\u00a08918464.Further reading[edit]Li BQ, Wang MH, Kung HF,  et\u00a0al. (1995). “Macrophage-stimulating protein activates Ras by both activation and translocation of SOS nucleotide exchange factor”. Biochem. Biophys. Res. Commun. 216 (1): 110\u20138. doi:10.1006\/bbrc.1995.2598. PMID\u00a07488076.Wang MH, Ronsin C, Gesnel MC,  et\u00a0al. (1994). “Identification of the ron gene product as the receptor for the human macrophage stimulating protein”. Science. 266 (5182): 117\u20139. Bibcode:1994Sci…266..117W. doi:10.1126\/science.7939629. PMID\u00a07939629.Gaudino G, Follenzi A, Naldini L,  et\u00a0al. (1994). “RON is a heterodimeric tyrosine kinase receptor activated by the HGF homologue MSP”. EMBO J. 13 (15): 3524\u201332. doi:10.1002\/j.1460-2075.1994.tb06659.x. PMC\u00a0395256. PMID\u00a08062829.Lee ST, Strunk KM, Spritz RA (1993). “A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes”. Oncogene. 8 (12): 3403\u201310. PMID\u00a08247543.Collesi C, Santoro MM, Gaudino G, Comoglio PM (1996). “A splicing variant of the RON transcript induces constitutive tyrosine kinase activity and an invasive phenotype”. Mol. Cell. Biol. 16 (10): 5518\u201326. doi:10.1128\/MCB.16.10.5518. PMC\u00a0231551. PMID\u00a08816464.Bonaldo MF, Lennon G, Soares MB (1997). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Res. 6 (9): 791\u2013806. doi:10.1101\/gr.6.9.791. PMID\u00a08889548.Iwama A, Yamaguchi N, Suda T (1997). “STK\/RON receptor tyrosine kinase mediates both apoptotic and growth signals via the multifunctional docking site conserved among the HGF receptor family”. EMBO J. 15 (21): 5866\u201375. doi:10.1002\/j.1460-2075.1996.tb00973.x. PMC\u00a0452340. PMID\u00a08918464.Sakamoto O, Iwama A, Amitani R,  et\u00a0al. (1997). “Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility”. J. Clin. Invest. 99 (4): 701\u20139. doi:10.1172\/JCI119214. PMC\u00a0507853. PMID\u00a09045873.Follenzi A, Bakovic S, Gual P,  et\u00a0al. (2000). “Cross-talk between the proto-oncogenes Met and Ron”. Oncogene. 19 (27): 3041\u20139. doi:10.1038\/sj.onc.1203620. PMID\u00a010871856.Chen YQ, Zhou YQ, Fisher JH, Wang MH (2002). “Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: oncogenic potential of RON in vivo”. Oncogene. 21 (41): 6382\u20136. doi:10.1038\/sj.onc.1205783. PMID\u00a012214279.Chen YQ, Zhou YQ, Fu LH,  et\u00a0al. (2002). “Multiple pulmonary adenomas in the lung of transgenic mice overexpressing the RON receptor tyrosine kinase. Recepteur d’origine nantais”. Carcinogenesis. 23 (11): 1811\u20139. doi:10.1093\/carcin\/23.11.1811. PMID\u00a012419829.Zhou YQ, He C, Chen YQ,  et\u00a0al. (2003). “Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential”. Oncogene. 22 (2): 186\u201397. doi:10.1038\/sj.onc.1206075. PMID\u00a012527888.Danilkovitch-Miagkova A, Duh FM, Kuzmin I,  et\u00a0al. (2003). “Hyaluronidase 2 negatively regulates RON receptor tyrosine kinase and mediates transformation of epithelial cells by jaagsiekte sheep retrovirus”. Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4580\u20135. Bibcode:2003PNAS..100.4580D. doi:10.1073\/pnas.0837136100. PMC\u00a0153598. PMID\u00a012676986.Rampino T, Gregorini M, Soccio G,  et\u00a0al. (2003). “The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma”. Am. J. Surg. Pathol. 27 (6): 779\u201385. doi:10.1097\/00000478-200306000-00008. PMID\u00a012766581. S2CID\u00a021112098.Penengo L, Rubin C, Yarden Y, Gaudino G (2003). “c-Cbl is a critical modulator of the Ron tyrosine kinase receptor”. Oncogene. 22 (24): 3669\u201379. doi:10.1038\/sj.onc.1206585. PMID\u00a012802274.Maggiora P, Lorenzato A, Fracchioli S,  et\u00a0al. (2003). “The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness”. Exp. Cell Res. 288 (2): 382\u20139. doi:10.1016\/S0014-4827(03)00250-7. PMID\u00a012915129.Santoro MM, Gaudino G, Marchisio PC (2003). “The MSP receptor regulates alpha6beta4 and alpha3beta1 integrins via 14-3-3 proteins in keratinocyte migration”. Dev. Cell. 5 (2): 257\u201371. doi:10.1016\/S1534-5807(03)00201-6. PMID\u00a012919677.Angeloni D, Danilkovitch-Miagkova A, Miagkov A,  et\u00a0al. (2004). “The soluble sema domain of the RON receptor inhibits macrophage-stimulating protein-induced receptor activation”. J. Biol. Chem. 279 (5): 3726\u201332. doi:10.1074\/jbc.M309342200. PMID\u00a014597639.van den Akker E, van Dijk T, Parren-van Amelsvoort M,  et\u00a0al. (2004). “Tyrosine kinase receptor RON functions downstream of the erythropoietin receptor to induce expansion of erythroid progenitors”. Blood. 103 (12): 4457\u201365. doi:10.1182\/blood-2003-08-2713. PMID\u00a014982882. S2CID\u00a08097946.Raeppel S, Gaudette G,  et\u00a0al. (2010). “Identification of a novel series of potent RON receptor tyrosine kinase inhibitors”. Bioorg. Med. Chem. Lett. 20 (9): 2745\u20139. doi:10.1016\/j.bmcl.2010.03.073. PMID\u00a020363625.AngiopoietinCNTFEGF (ErbB)FGFFGFR1FGFR2Agonists: ErsoferminFGF (1, 2 (bFGF), 3, 4, 5, 6, 7 (KGF), 8, 9, 10 (KGF2), 17, 18, 22)PaliferminRepiferminSelpercatinibSpriferminTraferminFGFR3FGFR4UnsortedHGF (c-Met)IGFLNGF (p75NTR)PDGFRET (GFL)SCF (c-Kit)TGF\u03b2TrkTrkANegative allosteric modulators: VM-902ATrkBAgonists: 3,7-DHF3,7,8,2′-THF4′-DMA-7,8-DHF7,3′-DHF7,8-DHF7,8,2′-THF7,8,3′-THFAmitriptylineBDNFBNN-20DeoxygeduninDeprenylDiosmetinDMAQ-B1HIOCLM22A-4N-AcetylserotoninNT-3NT-4Norwogonin (5,7,8-THF)R7R13TDP6TrkCVEGFOthersAdditional growth factors: AdrenomedullinColony-stimulating factors (see here instead)Connective tissue growth factor (CTGF)Ephrins (A1, A2, A3, A4, A5, B1, B2, B3)Erythropoietin (see here instead)Glucose-6-phosphate isomerase (GPI; PGI, PHI, AMF)Glia maturation factor (GMF)Hepatoma-derived growth factor (HDGF)Interleukins\/T-cell growth factors (see here instead)Leukemia inhibitory factor (LIF)Macrophage-stimulating protein (MSP; HLP, HGFLP)Midkine (NEGF2)Migration-stimulating factor (MSF; PRG4)OncomodulinPituitary adenylate cyclase-activating peptide (PACAP)PleiotrophinRenalaseThrombopoietin (see here instead)Wnt signaling proteinsAdditional growth factor receptor modulators: Cerebrolysin (neurotrophin mixture)  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/mst1r-wikipedia\/#breadcrumbitem","name":"MST1R – Wikipedia"}}]}]