[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/myoferlin-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/myoferlin-wikipedia\/","headline":"Myoferlin – Wikipedia","name":"Myoferlin – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Myoferlin is a protein that in","datePublished":"2022-07-15","dateModified":"2022-07-15","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/1\/12\/PDB_2dmh_EBI.png\/180px-PDB_2dmh_EBI.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/1\/12\/PDB_2dmh_EBI.png\/180px-PDB_2dmh_EBI.png","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/myoferlin-wikipedia\/","wordCount":4625,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensMyoferlin is a protein that in humans is encoded by the MYOF gene.[5][6][7][8]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. Myoferlin contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Myoferlin also contains a FerA domain. FerA domains have been shown to interact with the membrane, suggesting that FerA domain in myoferlin may contribute to myoferlin’s membrane interaction mechanism.[9] Myoferlin is overexpressed in several types of cancers, especially triple-negative breast cancer. Overexpression of myoferlin is associated with proliferation, migration and invasion of cancer cells and silencing myoferlin’s gene in triple-negative breast cancer can significantly reduce tumor growth and metastatic progression.[10] Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length natures have not been determined.[8]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000138119 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048612 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Davis DB, Delmonte AJ, Ly CT, McNally EM (Feb 2000). “Myoferlin, a candidate gene and potential modifier of muscular dystrophy”. Hum Mol Genet. 9 (2): 217\u201326. doi:10.1093\/hmg\/9.2.217. PMID\u00a010607832.^ Britton S, Freeman T, Vafiadaki E, Keers S, Harrison R, Bushby K, Bashir R (Nov 2000). “The third human FER-1-like protein is highly similar to dysferlin”. Genomics. 68 (3): 313\u201321. doi:10.1006\/geno.2000.6290. PMID\u00a010995573.^ Bernatchez PN, Acevedo L, Fernandez-Hernando C, Murata T, Chalouni C, Kim J, Erdjument-Bromage H, Shah V, Gratton JP, McNally EM, Tempst P, Sessa WC (Oct 2007). “Myoferlin regulates vascular endothelial growth factor receptor-2 stability and function”. J Biol Chem. 282 (42): 30745\u201353. doi:10.1074\/jbc.M704798200. PMID\u00a017702744.^ a b “Entrez Gene: FER1L3 fer-1-like 3, myoferlin (C. elegans)”.^ Harsini, Faraz M; Chebrolu, Sukanya; Fuson, Kerry L; White, Mark A; Rice, Anne M; Sutton, Roger B (19 July 2018). “FerA is a Membrane-Associating Four-Helix Bundle Domain in the Ferlin Family of Membrane-Fusion Proteins”. Scientific Reports. 8 (1): 10949. Bibcode:2018NatSR…810949H. doi:10.1038\/s41598-018-29184-1. PMC\u00a06053371. PMID\u00a030026467.^ Blomme, A; Costanza, B; de Tullio, P; Thiry, M; Van Simaeys, G; Boutry, S; Doumont, G; Di Valentin, E; Hirano, T; Yokobori, T; Gofflot, S; Peulen, O; Bellahc\u00e8ne, A; Sherer, F; Le Goff, C; Cavalier, E; Mouithys-Mickalad, A; Jouret, F; Cusumano, PG; Lifrange, E; Muller, RN; Goldman, S; Delvenne, P; De Pauw, E; Nishiyama, M; Castronovo, V; Turtoi, A (April 2017). “Myoferlin regulates cellular lipid metabolism and promotes metastases in triple-negative breast cancer”. Oncogene. 36 (15): 2116\u20132130. doi:10.1038\/onc.2016.369. PMID\u00a027775075. S2CID\u00a026225163.Further reading[edit]Nakajima D, Okazaki N, Yamakawa H,  et\u00a0al. (2003). “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones”. DNA Res. 9 (3): 99\u2013106. doi:10.1093\/dnares\/9.3.99. PMID\u00a012168954.Nagase T, Ishikawa K, Kikuno R,  et\u00a0al. (2000). “Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 6 (5): 337\u201345. doi:10.1093\/dnares\/6.5.337. PMID\u00a010574462.Andersen JS, Lyon CE, Fox AH,  et\u00a0al. (2002). “Directed proteomic analysis of the human nucleolus”. Curr. Biol. 12 (1): 1\u201311. doi:10.1016\/S0960-9822(01)00650-9. PMID\u00a011790298. S2CID\u00a014132033.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Deloukas P, Earthrowl ME, Grafham DV,  et\u00a0al. (2004). “The DNA sequence and comparative analysis of human chromosome 10”. Nature. 429 (6990): 375\u201381. Bibcode:2004Natur.429..375D. doi:10.1038\/nature02462. PMID\u00a015164054.Beausoleil SA, Jedrychowski M, Schwartz D,  et\u00a0al. (2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130\u20135. Bibcode:2004PNAS..10112130B. doi:10.1073\/pnas.0404720101. PMC\u00a0514446. PMID\u00a015302935.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Olsen JV, Blagoev B, Gnad F,  et\u00a0al. (2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983. S2CID\u00a07827573.PDB gallery2dmh: Solution structure of the first C2 domain of human myoferlin       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/myoferlin-wikipedia\/#breadcrumbitem","name":"Myoferlin – Wikipedia"}}]}]