[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/necab3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/necab3-wikipedia\/","headline":"NECAB3 – Wikipedia","name":"NECAB3 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens N-terminal EF-hand calcium-binding protein 3 is","datePublished":"2019-03-14","dateModified":"2019-03-14","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/necab3-wikipedia\/","about":["Wiki"],"wordCount":3148,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensN-terminal EF-hand calcium-binding protein 3 is a protein that in humans is encoded by the NECAB3 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The protein encoded by this gene interacts with the amino-terminal domain of the amyloid beta A4 precursor protein-binding family A member 2 (APBA2), inhibits the association of APBA2 with amyloid precursor protein through a non-competitive mechanism, and abolishes the suppression of beta-amyloid production by APBA2. This protein, together with APBA2, may play an important role in the regulatory system of amyloid precursor protein metabolism and beta-amyloid generation. This gene consists of at least 13 exons and its alternative splicing generates at least 2 transcript variants.[6]Table of ContentsSee also[edit]References[edit]External links[edit]Further reading[edit]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000125967 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027489 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Lee DS, Tomita S, Kirino Y, Suzuki T (Aug 2000). “Regulation of X11L-dependent amyloid precursor protein metabolism by XB51, a novel X11L-binding protein”. J Biol Chem. 275 (30): 23134\u20138. doi:10.1074\/jbc.C000302200. PMID\u00a010833507.^ a b “Entrez Gene: APBA2BP amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein”.External links[edit]Further reading[edit]B\u00fcssow K, Cahill D, Nietfeld W,  et\u00a0al. (1998). “A method for global protein expression and antibody screening on high-density filters of an arrayed cDNA library”. Nucleic Acids Res. 26 (21): 5007\u20138. doi:10.1093\/nar\/26.21.5007. PMC\u00a0147919. PMID\u00a09776767.Sugita S, S\u00fcdhof TC (2000). “Specificity of Ca2+-dependent protein interactions mediated by the C2A domains of synaptotagmins”. Biochemistry. 39 (11): 2940\u20139. doi:10.1021\/bi9920984. PMID\u00a010715114.Deloukas P, Matthews LH, Ashurst J,  et\u00a0al. (2002). “The DNA sequence and comparative analysis of human chromosome 20”. Nature. 414 (6866): 865\u201371. Bibcode:2001Natur.414..865D. doi:10.1038\/414865a. PMID\u00a011780052.Sugita S, Ho A, S\u00fcdhof TC (2002). “NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern”. Neuroscience. 112 (1): 51\u201363. doi:10.1016\/S0306-4522(02)00063-5. PMID\u00a012044471. S2CID\u00a018740496.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Sumioka A, Imoto S, Martins RN,  et\u00a0al. (2003). “XB51 isoforms mediate Alzheimer’s beta-amyloid peptide production by X11L (X11-like protein)-dependent and -independent mechanisms”. Biochem. J. 374 (Pt 1): 261\u20138. doi:10.1042\/BJ20030489. PMC\u00a01223589. PMID\u00a012780348.Yoo JC, Chang JR, Kim SH,  et\u00a0al. (2004). “NIP1\/XB51\/NECAB3 is a potential substrate of Nek2, suggesting specific roles of Nek2 in Golgi”. Exp. Cell Res. 292 (2): 393\u2013402. doi:10.1016\/j.yexcr.2003.09.025. PMID\u00a014697346.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.       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