[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/nefm-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/nefm-wikipedia\/","headline":"NEFM – Wikipedia","name":"NEFM – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Neurofilament medium polypeptide (NF-M) is a protein that","datePublished":"2016-11-05","dateModified":"2016-11-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/nefm-wikipedia\/","wordCount":4436,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensNeurofilament medium polypeptide (NF-M) is a protein that in humans is encoded by the NEFM gene.[3][4]Function[edit]Neurofilaments are type IV intermediate filament heteropolymers composed of light (NEFL), medium (this protein), and heavy (NEFH) chains. Neurofilaments comprise the exoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage.[4]References[edit]Further reading[edit]Xu ZS, Liu WS, Willard MB (1992). “Identification of six phosphorylation sites in the COOH-terminal tail region of the rat neurofilament protein M.” J. Biol. Chem. 267 (7): 4467\u201371. doi:10.1016\/S0021-9258(18)42856-6. PMID\u00a01537832.Lee VM, Otvos L, Carden MJ,  et\u00a0al. (1988). “Identification of the major multiphosphorylation site in mammalian neurofilaments”. Proc. Natl. Acad. Sci. U.S.A. 85 (6): 1998\u20132002. Bibcode:1988PNAS…85.1998L. doi:10.1073\/pnas.85.6.1998. PMC\u00a0279909. PMID\u00a02450354.Chin TK, Harding SE, Eagles PA (1990). “Characterization of two proteolytically derived soluble polypeptides from the neurofilament triplet components NFM and NFH”. Biochem. J. 264 (1): 53\u201360. doi:10.1042\/bj2640053. PMC\u00a01133546. PMID\u00a02557834.Myers MW, Lazzarini RA, Lee VM,  et\u00a0al. (1987). “The human mid-size neurofilament subunit: a repeated protein sequence and the relationship of its gene to the intermediate filament gene family”. EMBO J. 6 (6): 1617\u201326. doi:10.1002\/j.1460-2075.1987.tb02409.x. PMC\u00a0553533. PMID\u00a03608989.Tu PH, Elder G, Lazzarini RA,  et\u00a0al. (1995). “Overexpression of the human NFM subunit in transgenic mice modifies the level of endogenous NFL and the phosphorylation state of NFH subunits”. J. Cell Biol. 129 (6): 1629\u201340. doi:10.1083\/jcb.129.6.1629. PMC\u00a02291190. PMID\u00a07790359.Robertson NG, Khetarpal U, Guti\u00e9rrez-Espeleta GA,  et\u00a0al. (1995). “Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening”. Genomics. 23 (1): 42\u201350. doi:10.1006\/geno.1994.1457. PMID\u00a07829101.Dong DL, Xu ZS, Chevrier MR,  et\u00a0al. (1993). “Glycosylation of mammalian neurofilaments. Localization of multiple O-linked N-acetylglucosamine moieties on neurofilament polypeptides L and M.” J. Biol. Chem. 268 (22): 16679\u201387. doi:10.1016\/S0021-9258(19)85471-6. PMID\u00a08344946.Fleming LM, Weisgraber KH, Strittmatter WJ,  et\u00a0al. (1996). “Differential binding of apolipoprotein E isoforms to tau and other cytoskeletal proteins”. Exp. Neurol. 138 (2): 252\u201360. doi:10.1006\/exnr.1996.0064. PMID\u00a08620924. S2CID\u00a046328348.Dong DL, Xu ZS, Hart GW, Cleveland DW (1996). “Cytoplasmic O-GlcNAc modification of the head domain and the KSP repeat motif of the neurofilament protein neurofilament-H”. J. Biol. Chem. 271 (34): 20845\u201352. doi:10.1074\/jbc.271.34.20845. PMID\u00a08702840.Veeranna GJ, Shetty KT, Takahashi M,  et\u00a0al. (2000). “Cdk5 and MAPK are associated with complexes of cytoskeletal proteins in rat brain”. Brain Res. Mol. Brain Res. 76 (2): 229\u201336. doi:10.1016\/S0169-328X(00)00003-6. PMID\u00a010762698.Taylor JP, Sater R, French J,  et\u00a0al. (2002). “Transcription of intermediate filament genes is enhanced in focal cortical dysplasia”. Acta Neuropathol. 102 (2): 141\u20138. doi:10.1007\/s004010000348. PMID\u00a011563628. S2CID\u00a023648593.Wang Y, Wang Q, Wang J (2002). “[Detection of level and mutation of neurofilament mRNA in Alzheimer’s disease]”. Zhonghua Yi Xue Za Zhi. 82 (8): 519\u201322. PMID\u00a012133495.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Bhaskar K, Shareef MM, Sharma VM,  et\u00a0al. (2003). “Co-purification and localization of Munc18-1 (p67) and Cdk5 with neuronal cytoskeletal proteins”. Neurochem. Int. 44 (1): 35\u201344. doi:10.1016\/S0197-0186(03)00099-8. PMID\u00a012963086. S2CID\u00a023783141.Kr\u00fcger R, Fischer C, Schulte T,  et\u00a0al. (2004). “Mutation analysis of the neurofilament M gene in Parkinson’s disease”. Neurosci. Lett. 351 (2): 125\u20139. doi:10.1016\/S0304-3940(03)00903-0. PMID\u00a014583397. S2CID\u00a023425379.Garcia ML, Lobsiger CS, Shah SB,  et\u00a0al. (2004). “NF-M is an essential target for the myelin-directed “outside-in” signaling cascade that mediates radial axonal growth”. J. Cell Biol. 163 (5): 1011\u201320. doi:10.1083\/jcb.200308159. PMC\u00a02173620. PMID\u00a014662745.Perez-Olle R, Lopez-Toledano MA, Liem RK (2004). “The G336S variant in the human neurofilament-M gene does not affect its assembly or distribution: importance of the functional analysis of neurofilament variants”. J. Neuropathol. Exp. Neurol. 63 (7): 759\u201374. doi:10.1093\/jnen\/63.7.759. PMID\u00a015290901.Suzuki Y, Yamashita R, Shirota M,  et\u00a0al. (2004). “Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions”. Genome Res. 14 (9): 1711\u20138. doi:10.1101\/gr.2435604. PMC\u00a0515316. PMID\u00a015342556.DeGiorgis JA, Jaffe H, Moreira JE,  et\u00a0al. (2005). “Phosphoproteomic analysis of synaptosomes from human cerebral cortex”. J. Proteome Res. 4 (2): 306\u201315. doi:10.1021\/pr0498436. PMID\u00a015822905.This article incorporates text from the United States National Library of Medicine, which is in the public domain.  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