[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/nrxn2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/nrxn2-wikipedia\/","headline":"NRXN2 – Wikipedia","name":"NRXN2 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Neurexin-2-alpha is a protein that in","datePublished":"2022-08-03","dateModified":"2022-08-03","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/nrxn2-wikipedia\/","about":["Wiki"],"wordCount":3256,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensNeurexin-2-alpha is a protein that in humans is encoded by the NRXN2 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Neurexins are a family of proteins that function in the vertebrate nervous system as cell adhesion molecules and receptors. They are encoded by several unlinked genes of which two, NRXN1 and NRXN3, are among the largest known human genes. Three of the genes (NRXN1-3) utilize two alternate promoters and include numerous alternatively spliced exons to generate thousands of distinct mRNA transcripts and protein isoforms. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms; a much smaller number of transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins.[6]References[edit]Further reading[edit]Nakajima D, Okazaki N, Yamakawa H,  et\u00a0al. (2003). “Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones”. DNA Res. 9 (3): 99\u2013106. doi:10.1093\/dnares\/9.3.99. PMID\u00a012168954.Ichtchenko K, Nguyen T, S\u00fcdhof TC (1996). “Structures, alternative splicing, and neurexin binding of multiple neuroligins”. J. Biol. Chem. 271 (5): 2676\u20132682. doi:10.1074\/jbc.271.5.2676. PMID\u00a08576240.Hata Y, Butz S, S\u00fcdhof TC (1996). “CASK: a novel dlg\/PSD95 homolog with an N-terminal calmodulin-dependent protein kinase domain identified by interaction with neurexins”. J. Neurosci. 16 (8): 2488\u201394. doi:10.1523\/JNEUROSCI.16-08-02488.1996. PMC\u00a06578772. PMID\u00a08786425.Kurschner C, Mermelstein PG, Holden WT, Surmeier DJ (1998). “CIPP, a novel multivalent PDZ domain protein, selectively interacts with Kir4.0 family members, NMDA receptor subunits, neurexins, and neuroligins”. Mol. Cell. Neurosci. 11 (3): 161\u2013172. doi:10.1006\/mcne.1998.0679. PMID\u00a09647694. S2CID\u00a036534759.Hock B, B\u00f6hme B, Karn T,  et\u00a0al. (1998). “PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor”. Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779\u20139784. Bibcode:1998PNAS…95.9779H. doi:10.1073\/pnas.95.17.9779. PMC\u00a021413. PMID\u00a09707552.Bergman L, Silins G, Grimmond S,  et\u00a0al. (1999). “A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13”. Genomics. 55 (1): 49\u201356. doi:10.1006\/geno.1998.5625. PMID\u00a09888998.Nagase T, Ishikawa K, Suyama M,  et\u00a0al. (1999). “Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 6 (1): 63\u201370. doi:10.1093\/dnares\/6.1.63. PMID\u00a010231032.Rowen L, Young J, Birditt B,  et\u00a0al. (2002). “Analysis of the human neurexin genes: alternative splicing and the generation of protein diversity”. Genomics. 79 (4): 587\u2013597. doi:10.1006\/geno.2002.6734. PMID\u00a011944992.Tabuchi K, S\u00fcdhof TC (2002). “Structure and evolution of neurexin genes: insight into the mechanism of alternative splicing”. Genomics. 79 (6): 849\u2013859. doi:10.1006\/geno.2002.6780. PMID\u00a012036300.Nakayama M, Kikuno R, Ohara O (2003). “Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs”. Genome Res. 12 (11): 1773\u20131784. doi:10.1101\/gr.406902. PMC\u00a0187542. PMID\u00a012421765.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u201345. doi:10.1038\/ng1285. PMID\u00a014702039.Homma K, Kikuno RF, Nagase T,  et\u00a0al. (2004). “Alternative splice variants encoding unstable protein domains exist in the human brain”. J. Mol. Biol. 343 (5): 1207\u20131220. doi:10.1016\/j.jmb.2004.09.028. PMID\u00a015491607.Taylor TD, Noguchi H, Totoki Y,  et\u00a0al. (2006). “Human chromosome 11 DNA sequence and analysis including novel gene identification”. Nature. 440 (7083): 497\u2013500. Bibcode:2006Natur.440..497T. doi:10.1038\/nature04632. PMID\u00a016554811.     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/nrxn2-wikipedia\/#breadcrumbitem","name":"NRXN2 – Wikipedia"}}]}]