[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/nuak1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/nuak1-wikipedia\/","headline":"NUAK1 – Wikipedia","name":"NUAK1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens NUAK family SNF1-like kinase 1 also","datePublished":"2015-03-11","dateModified":"2015-03-11","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/nuak1-wikipedia\/","wordCount":4486,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensNUAK family SNF1-like kinase 1 also known as AMPK-related protein kinase 5 (ARK5) is an enzyme that in humans is encoded by the NUAK1 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Clinical significance[edit]Research findings[edit]As a drug target[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]Acts as a regulator of cellular senescence and cellular ploidy by mediating phosphorylation of ‘Ser-464’ of LATS1, thereby controlling its stability. Controls cell adhesion by regulating activity of the myosin protein phosphatase 1 (PP1) complex.[8]Clinical significance[edit]ARK5 is important in tumor malignancy and invasiveness.[9]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Research findings[edit]ARK5 is often overexpressed in multiple myeloma cell lines.[10][11]ARK5 promotes tumor cell survival under regulation by Akt.[9]ARK5 increases MT1-MMP production.[9] (MT1-MMP activates MMP-2 and MMP-9 which are involved in tumor metastasis.[9])As a drug target[edit]ON123300 (a CDK4 inhibitor), also inhibits ARK5 and reduces proliferation of multiple myeloma and mantle cell lymphoma cell lines.[10]Interactions[edit]NUAK1 has been shown to interact with USP9X[12] and Ubiquitin C.[12]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000074590 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020032 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Lavin MF, Esumi H (Dec 2002). “Identification of a novel protein kinase mediating Akt survival signaling to the ATM protein” (PDF). J Biol Chem. 278 (1): 48\u201353. doi:10.1074\/jbc.M206025200. PMID\u00a012409306. S2CID\u00a023605132.^ Suzuki A, Kusakai G, Kishimoto A, Lu J, Ogura T, Esumi H (Sep 2003). “ARK5 suppresses the cell death induced by nutrient starvation and death receptors via inhibition of caspase 8 activation, but not by chemotherapeutic agents or UV irradiation”. Oncogene. 22 (40): 6177\u201382. doi:10.1038\/sj.onc.1206899. PMID\u00a013679856.^ “Entrez Gene: NUAK1 NUAK family, SNF1-like kinase, 1”.^ Protein Coding (2021-11-14). “NUAK1 Gene – NUAK Family Kinase 1”. Gene Cards. Retrieved 2021-12-19.^ a b c d Suzuki A, Lu J, Kusakai G et\u00a0al. (2004). “ARK5 is a tumor invasion-associated factor downstream of Akt signaling”. Mol. Cell. Biol. 24 (8): 3526\u201335. doi:10.1128\/MCB.24.8.3526-3535.2004. PMC\u00a0381626. PMID\u00a015060171.{{cite journal}}:  CS1 maint: uses authors parameter (link)^ a b Multi-Target Drug Blocks Myeloma Proliferation. March 2016^ Deepak Perumal et\u00a0al. (2014). “Dual targeting of CDK4 and ARK5 using a novel kinase inhibitor ON123300 is effective in vitro and in vivo in Multiple Myeloma”. Proceedings of the 105th Annual Meeting of the American Association for Cancer Research; 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res. 74: 1324. doi:10.1158\/1538-7445.AM2014-1324.{{cite journal}}:  CS1 maint: uses authors parameter (link)^ a b Al-Hakim, Abdallah K; Zagorska Anna; Chapman Louise; Deak Maria; Peggie Mark; Alessi Dario R (Apr 2008). “Control of AMPK-related kinases by USP9X and atypical Lys(29)\/Lys(33)-linked polyubiquitin chains” (PDF). Biochem. J. England. 411 (2): 249\u201360. doi:10.1042\/BJ20080067. PMID\u00a018254724. S2CID\u00a013038944.Further reading[edit]Nagase T, Ishikawa K, Miyajima N,  et\u00a0al. (1998). “Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro”. DNA Res. 5 (1): 31\u20139. doi:10.1093\/dnares\/5.1.31. PMID\u00a09628581.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Lizcano JM, G\u00f6ransson O, Toth R,  et\u00a0al. (2005). “LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK\/PAR-1”. EMBO J. 23 (4): 833\u201343. doi:10.1038\/sj.emboj.7600110. PMC\u00a0381014. PMID\u00a014976552.Suzuki A, Kusakai G, Kishimoto A,  et\u00a0al. (2004). “Regulation of caspase-6 and FLIP by the AMPK family member ARK5”. Oncogene. 23 (42): 7067\u201375. doi:10.1038\/sj.onc.1207963. PMID\u00a015273717.Kusakai G, Suzuki A, Ogura T,  et\u00a0al. (2005). “Strong association of ARK5 with tumor invasion and metastasis”. J. Exp. Clin. Cancer Res. 23 (2): 263\u20138. PMID\u00a015354411.Suzuki A, Iida S, Kato-Uranishi M,  et\u00a0al. (2006). “ARK5 is transcriptionally regulated by the Large-MAF family and mediates IGF-1-induced cell invasion in multiple myeloma: ARK5 as a new molecular determinant of malignant multiple myeloma”. Oncogene. 24 (46): 6936\u201344. doi:10.1038\/sj.onc.1208844. PMID\u00a016044163.Al-Hakim AK, G\u00f6ransson O, Deak M,  et\u00a0al. (2006). “14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK”. J. Cell Sci. 118 (Pt 23): 5661\u201373. doi:10.1242\/jcs.02670. PMID\u00a016306228.Suzuki A, Ogura T, Esumi H (2006). “NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling”. J. Biol. Chem. 281 (20): 13915\u201321. doi:10.1074\/jbc.M511354200. PMID\u00a016488889.Ewing RM, Chu P, Elisma F,  et\u00a0al. (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Mol. Syst. Biol. 3 (1): 89. doi:10.1038\/msb4100134. PMC\u00a01847948. PMID\u00a017353931.       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