[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/oas2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/oas2-wikipedia\/","headline":"OAS2 – Wikipedia","name":"OAS2 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens 2′-5′-oligoadenylate synthetase 2 is an enzyme","datePublished":"2016-09-17","dateModified":"2016-09-17","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/oas2-wikipedia\/","wordCount":3916,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiens2′-5′-oligoadenylate synthetase 2 is an enzyme that in humans is encoded by the OAS2 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2′-specific nucleotidyl transfer reactions to synthesize 2′,5′-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively spliced transcript variants encoding different isoforms have been described.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000111335 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000032690 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Hovnanian A, Rebouillat D, Mattei MG, Levy ER, Marie I, Monaco AP, Hovanessian AG (Dec 1998). “The human 2′,5′-oligoadenylate synthetase locus is composed of three distinct genes clustered on chromosome 12q24.2 encoding the 100-, 69-, and 40-kDa forms”. Genomics. 52 (3): 267\u2013277. doi:10.1006\/geno.1998.5443. PMID\u00a09790745.^ a b “Entrez Gene: OAS2 2′-5′-oligoadenylate synthetase 2, 69\/71kDa”.Further reading[edit]Justesen J, Hartmann R, Kjeldgaard NO (2000). “Gene structure and function of the 2′-5′-oligoadenylate synthetase family”. Cell. Mol. Life Sci. 57 (11): 1593\u20131612. doi:10.1007\/PL00000644. PMID\u00a011092454. S2CID\u00a019154357.Mari\u00e9 I, Hovanessian AG (1992). “The 69-kDa 2-5A synthetase is composed of two homologous and adjacent functional domains”. J. Biol. Chem. 267 (14): 9933\u20139. doi:10.1016\/S0021-9258(19)50182-X. PMID\u00a01577824.Silverman RH, Sengupta DN (1991). “Translational regulation by HIV leader RNA, TAT, and interferon-inducible enzymes”. J. Exp. Pathol. 5 (2): 69\u201377. PMID\u00a01708818.Mari\u00e9 I, Svab J, Robert N,  et\u00a0al. (1990). “Differential expression and distinct structure of 69- and 100-kDa forms of 2-5A synthetase in human cells treated with interferon”. J. Biol. Chem. 265 (30): 18601\u20137. doi:10.1016\/S0021-9258(17)44794-6. PMID\u00a02211721.Hovanessian AG, Laurent AG, Chebath J,  et\u00a0al. (1987). “Identification of 69-kd and 100-kd forms of 2-5A synthetase in interferon-treated human cells by specific monoclonal antibodies”. EMBO J. 6 (5): 1273\u201380. doi:10.1002\/j.1460-2075.1987.tb02364.x. PMC\u00a0553929. PMID\u00a02440675.Mari\u00e9 I, Galabru J, Svab J, Hovanessian AG (1989). “Preparation and characterization of polyclonal antibodies specific for the 69 and 100 k-dalton forms of human 2-5A synthetase”. Biochem. Biophys. Res. Commun. 160 (2): 580\u2013587. doi:10.1016\/0006-291X(89)92472-8. PMID\u00a02470369.Hovanessian AG, Svab J, Mari\u00e9 I,  et\u00a0al. (1988). “Characterization of 69- and 100-kDa forms of 2-5A-synthetase from interferon-treated human cells”. J. Biol. Chem. 263 (10): 4945\u20139. doi:10.1016\/S0021-9258(18)68878-7. PMID\u00a03350819.Solinas A, Cossu P, Poddighe P,  et\u00a0al. (1994). “Changes of serum 2′,5′-oligoadenylate synthetase activity during interferon treatment of chronic hepatitis C”. Liver. 13 (5): 253\u20138. doi:10.1111\/j.1600-0676.1993.tb00640.x. PMID\u00a08259037.Besse S, Rebouillat D, Marie I,  et\u00a0al. (1998). “Ultrastructural localization of interferon-inducible double-stranded RNA-activated enzymes in human cells”. Exp. Cell Res. 239 (2): 379\u2013392. doi:10.1006\/excr.1997.3908. PMID\u00a09521856.Sarkar SN, Ghosh A, Wang HW,  et\u00a0al. (1999). “The nature of the catalytic domain of 2′-5′-oligoadenylate synthetases”. J. Biol. Chem. 274 (36): 25535\u201325542. doi:10.1074\/jbc.274.36.25535. PMID\u00a010464285.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u201316903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20132127. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Scherer SE, Muzny DM, Buhay CJ,  et\u00a0al. (2006). “The finished DNA sequence of human chromosome 12”. Nature. 440 (7082): 346\u2013351. Bibcode:2006Natur.440..346S. doi:10.1038\/nature04569. PMID\u00a016541075.       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