[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/or7d4-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/or7d4-wikipedia\/","headline":"OR7D4 – Wikipedia","name":"OR7D4 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Olfactory receptor 7D4 is a protein","datePublished":"2014-12-05","dateModified":"2014-12-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/or7d4-wikipedia\/","about":["Wiki"],"wordCount":3059,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensOlfactory receptor 7D4 is a protein that in humans is encoded by the OR7D4 gene.[5][6][7][8][9][10][11]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Function[edit]Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]Ligands[edit]People with the OR7D4 R88W\/T133M polymorphism are less sensitive to these odorants and find them less offensive smelling, as they are characteristically described as “sweaty”.[8]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000174667 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000059623 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: OR7D4 olfactory receptor, family 7, subfamily D, member 4”. Retrieved 2013-12-17.^ Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O’Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R (September 2002). “DEFOG: a practical scheme for deciphering families of genes”. Genomics. 80 (3): 295\u2013302. CiteSeerX\u00a010.1.1.135.3652. doi:10.1006\/geno.2002.6830. PMID\u00a012213199.^ Malnic B, Godfrey PA, Buck LB (February 2004). “The human olfactory receptor gene family”. Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584\u20139. Bibcode:2004PNAS..101.2584M. doi:10.1073\/pnas.0307882100. PMC\u00a0356993. PMID\u00a014983052.^ a b Keller A, Zhuang H, Chi Q, Vosshall LB, Matsunami H (September 2007). “Genetic variation in a human odorant receptor alters odour perception”. Nature. 449 (7161): 468\u201372. Bibcode:2007Natur.449..468K. doi:10.1038\/nature06162. PMID\u00a017873857. S2CID\u00a04417235.^ OR7D4+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)^ Lunde K, Egelandsdal B, Skuterud E, Mainland JD, Lea T, Hersleth M, Matsunami H (2012).  Behrens M (ed.). “Genetic variation of an odorant receptor OR7D4 and sensory perception of cooked meat containing androstenone”. PLOS ONE. 7 (5): e35259. Bibcode:2012PLoSO…735259L. doi:10.1371\/journal.pone.0035259. PMC\u00a03342276. PMID\u00a022567099.^ Wysocki CJ, Beauchamp GK (August 1984). “Ability to smell androstenone is genetically determined”. Proceedings of the National Academy of Sciences of the United States of America. 81 (15): 4899\u2013902. Bibcode:1984PNAS…81.4899W. doi:10.1073\/pnas.81.15.4899. PMC\u00a0391599. PMID\u00a06589634.^ Hornung J, Noack H, Thomas M, Farger G, Nieratschker V, Freiherr J, Derntl B (February 2018). “Bayesian informed evidence against modulation of androstadienone-effects by genotypic receptor variants and participant sex: A study assessing Stroop interference control, mood and olfaction”. Hormones and Behavior. 98: 45\u201354. doi:10.1016\/j.yhbeh.2017.12.003. PMID\u00a029246659. S2CID\u00a03577638.^ de March CA, Topin J, Bruguera E, Novikov G, Ikegami K, Matsunami H, Golebiowski J (April 2018). “Odorant Receptor 7D4 Activation Dynamics”. Angewandte Chemie. 57 (17): 4554\u20134558. doi:10.1002\/anie.201713065. PMC\u00a06268213. PMID\u00a029462498.This article incorporates text from the United States National Library of Medicine, which is in the public domain.       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