[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/pcbp1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/pcbp1-wikipedia\/","headline":"PCBP1 – Wikipedia","name":"PCBP1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Poly(rC)-binding protein 1 is a protein","datePublished":"2016-10-19","dateModified":"2016-10-19","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/52\/PDB_1wvn_EBI.jpg\/180px-PDB_1wvn_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/52\/PDB_1wvn_EBI.jpg\/180px-PDB_1wvn_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/pcbp1-wikipedia\/","wordCount":5280,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensPoly(rC)-binding protein 1 is a protein that in humans is encoded by the PCBP1 gene.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4This intronless gene is thought to have been generated by retrotransposition of a fully processed PCBP-2 mRNA. This gene and PCBP-2 have paralogues (PCBP3 and PCBP4) which are thought to have arisen as a result of duplication events of entire genes. The protein encoded by this gene appears to be multifunctional. It along with PCBP2 and HNRNPK corresponds to the major cellular poly(rC)-binding protein. It contains three K-homologous (KH) domains which may be involved in RNA binding. This encoded protein together with PCBP-2 also functions as translational coactivators of poliovirus RNA via a sequence-specific interaction with stem-loop IV of the IRES and promote poliovirus RNA replication by binding to its 5′-terminal cloverleaf structure.It has also been implicated in translational control of the 15-lipoxygenase mRNA, human Papillomavirus type 16 L2 mRNA, and hepatitis A virus RNA. The encoded protein is also suggested to play a part in formation of a sequence-specific alpha-globin mRNP complex which is associated with alpha-globin mRNA stability.[6]References[edit]Further reading[edit]Kiledjian M, Wang X, Liebhaber SA (1995). “Identification of two KH domain proteins in the alpha-globin mRNP stability complex”. EMBO J. 14 (17): 4357\u201364. doi:10.1002\/j.1460-2075.1995.tb00110.x. PMC\u00a0394520. PMID\u00a07556077.Leffers H, Dejgaard K, Celis JE (1995). “Characterisation of two major cellular poly(rC)-binding human proteins, each containing three K-homologous (KH) domains”. Eur. J. Biochem. 230 (2): 447\u201353. doi:10.1111\/j.1432-1033.1995.tb20581.x. PMID\u00a07607214.Aasheim HC, Loukianova T, Deggerdal A, Smeland EB (1994). “Tissue specific expression and cDNA structure of a human transcript encoding a nucleic acid binding [oligo(dC)] protein related to the pre-mRNA binding protein K.” Nucleic Acids Res. 22 (6): 959\u201364. doi:10.1093\/nar\/22.6.959. PMC\u00a0307915. PMID\u00a08152927.Blyn LB, Swiderek KM, Richards O,  et\u00a0al. (1996). “Poly(rC) binding protein 2 binds to stem-loop IV of the poliovirus RNA 5′ noncoding region: identification by automated liquid chromatography-tandem mass spectrometry”. Proc. Natl. Acad. Sci. U.S.A. 93 (20): 11115\u201320. Bibcode:1996PNAS…9311115B. doi:10.1073\/pnas.93.20.11115. PMC\u00a038293. PMID\u00a08855318.Kiledjian M, DeMaria CT, Brewer G, Novick K (1997). “Identification of AUF1 (heterogeneous nuclear ribonucleoprotein D) as a component of the alpha-globin mRNA stability complex”. Mol. Cell. Biol. 17 (8): 4870\u20136. doi:10.1128\/MCB.17.8.4870. PMC\u00a0232339. PMID\u00a09234743.Wang Z, Day N, Trifillis P, Kiledjian M (1999). “An mRNA stability complex functions with poly(A)-binding protein to stabilize mRNA in vitro”. Mol. Cell. Biol. 19 (7): 4552\u201360. doi:10.1128\/MCB.19.7.4552. PMC\u00a084253. PMID\u00a010373504.Makeyev AV, Chkheidze AN, Liebhaber SA (1999). “A set of highly conserved RNA-binding proteins, alphaCP-1 and alphaCP-2, implicated in mRNA stabilization, are coexpressed from an intronless gene and its intron-containing paralog”. J. Biol. Chem. 274 (35): 24849\u201357. doi:10.1074\/jbc.274.35.24849. PMID\u00a010455157.Makeyev AV, Liebhaber SA (2000). “Identification of two novel mammalian genes establishes a subfamily of KH-domain RNA-binding proteins”. Genomics. 67 (3): 301\u201316. doi:10.1006\/geno.2000.6244. PMID\u00a010936052.Suzuki H, Fukunishi Y, Kagawa I,  et\u00a0al. (2001). “Protein-protein interaction panel using mouse full-length cDNAs”. Genome Res. 11 (10): 1758\u201365. doi:10.1101\/gr.180101. PMC\u00a0311163. PMID\u00a011591653.Andersen JS, Lyon CE, Fox AH,  et\u00a0al. (2002). “Directed proteomic analysis of the human nucleolus”. Curr. Biol. 12 (1): 1\u201311. doi:10.1016\/S0960-9822(01)00650-9. PMID\u00a011790298. S2CID\u00a014132033.Yeap BB, Voon DC, Vivian JP,  et\u00a0al. (2002). “Novel binding of HuR and poly(C)-binding protein to a conserved UC-rich motif within the 3′-untranslated region of the androgen receptor messenger RNA”. J. Biol. Chem. 277 (30): 27183\u201392. doi:10.1074\/jbc.M202883200. PMID\u00a012011088.Walter BL, Parsley TB, Ehrenfeld E, Semler BL (2002). “Distinct poly(rC) binding protein KH domain determinants for poliovirus translation initiation and viral RNA replication”. J. Virol. 76 (23): 12008\u201322. doi:10.1128\/JVI.76.23.12008-12022.2002. PMC\u00a0136902. PMID\u00a012414943.Giles KM, Daly JM, Beveridge DJ,  et\u00a0al. (2003). “The 3′-untranslated region of p21WAF1 mRNA is a composite cis-acting sequence bound by RNA-binding proteins from breast cancer cells, including HuR and poly(C)-binding protein”. J. Biol. Chem. 278 (5): 2937\u201346. doi:10.1074\/jbc.M208439200. PMID\u00a012431987.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Pickering BM, Mitchell SA, Evans JR, Willis AE (2003). “Polypyrimidine tract binding protein and poly r(C) binding protein 1 interact with the BAG-1 IRES and stimulate its activity in vitro and in vivo”. Nucleic Acids Res. 31 (2): 639\u201346. doi:10.1093\/nar\/gkg146. PMC\u00a0140511. PMID\u00a012527772.Pillai MR, Chacko P, Kesari LA,  et\u00a0al. (2003). “Expression of folate receptors and heterogeneous nuclear ribonucleoprotein E1 in women with human papillomavirus mediated transformation of cervical tissue to cancer”. J. Clin. Pathol. 56 (8): 569\u201374. doi:10.1136\/jcp.56.8.569. PMC\u00a01770025. PMID\u00a012890803.Adams DJ, Beveridge DJ, van der Weyden L,  et\u00a0al. (2004). “HADHB, HuR, and CP1 bind to the distal 3′-untranslated region of human renin mRNA and differentially modulate renin expression”. J. Biol. Chem. 278 (45): 44894\u2013903. doi:10.1074\/jbc.M307782200. PMID\u00a012933794.Evans JR, Mitchell SA, Spriggs KA,  et\u00a0al. (2003). “Members of the poly (rC) binding protein family stimulate the activity of the c-myc internal ribosome entry segment in vitro and in vivo”. Oncogene. 22 (39): 8012\u201320. doi:10.1038\/sj.onc.1206645. PMID\u00a012970749.Chkheidze AN, Liebhaber SA (2003). “A novel set of nuclear localization signals determine distributions of the alphaCP RNA-binding proteins”. Mol. Cell. Biol. 23 (23): 8405\u201315. doi:10.1128\/MCB.23.23.8405-8415.2003. PMC\u00a0262676. PMID\u00a014612387.PDB gallery1wvn: Crsytal Structure of domain 3 of human alpha polyC binding protein       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x41ztg: human alpha polyC binding protein KH12axy: Crystal Structure of KH1 domain of human Poly(C)-binding protein-2 with C-rich strand of human telomeric DNA       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/pcbp1-wikipedia\/#breadcrumbitem","name":"PCBP1 – Wikipedia"}}]}]