[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/pcolce-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/pcolce-wikipedia\/","headline":"PCOLCE – Wikipedia","name":"PCOLCE – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Procollagen C-endopeptidase enhancer 1 is an","datePublished":"2019-09-07","dateModified":"2019-09-07","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/d\/df\/PDB_1uap_EBI.jpg\/180px-PDB_1uap_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/d\/df\/PDB_1uap_EBI.jpg\/180px-PDB_1uap_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/pcolce-wikipedia\/","about":["Wiki"],"wordCount":4381,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensProcollagen C-endopeptidase enhancer 1 is an enzyme that in humans is encoded by the PCOLCE gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Fibrillar collagen types I-III are synthesized as precursor molecules known as procollagens. These precursors contain amino- and carboxyl-terminal peptide extensions known as N- and C-propeptides, respectively, which are cleaved, upon secretion of procollagen from the cell, to yield the mature triple helical, highly structured fibrils. This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens  activity.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000106333 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029718 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Takahara K, Osborne L, Elliott RW, Tsui LC, Scherer SW, Greenspan DS (Mar 1997). “Fine mapping of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein”. Genomics. 31 (2): 253\u2013256. doi:10.1006\/geno.1996.0043. PMID\u00a08824813.^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). “Large-scale sequencing of two regions in human chromosome 7q22: analysis of 650 kb of genomic sequence around the EPO and CUTL1 loci reveals 17 genes”. Genome Res. 8 (10): 1060\u20131073. doi:10.1101\/gr.8.10.1060. PMC\u00a0310788. PMID\u00a09799793.^ a b “Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer”.Further reading[edit]Takahara K, Kessler E, Biniaminov L,  et\u00a0al. (1994). “Type I procollagen COOH-terminal proteinase enhancer protein: identification, primary structure, and chromosomal localization of the cognate human gene (PCOLCE)”. J. Biol. Chem. 269 (42): 26280\u201326285. doi:10.1016\/S0021-9258(18)47191-8. PMID\u00a07523404.Scott IC, Clark TG, Takahara K,  et\u00a0al. (1999). “Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal proteinase enhancer protein”. Genomics. 55 (2): 229\u2013234. doi:10.1006\/geno.1998.5663. PMID\u00a09933570.Mott JD, Thomas CL, Rosenbach MT,  et\u00a0al. (2000). “Post-translational proteolytic processing of procollagen C-terminal proteinase enhancer releases a metalloproteinase inhibitor”. J. Biol. Chem. 275 (2): 1384\u20131390. doi:10.1074\/jbc.275.2.1384. PMID\u00a010625689.Ricard-Blum S, Bernocco S, Font B,  et\u00a0al. (2002). “Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1”. J. Biol. Chem. 277 (37): 33864\u201333869. doi:10.1074\/jbc.M205018200. PMID\u00a012105202.Ligon AH, Scott IC, Takahara K,  et\u00a0al. (2002). “PCOLCE deletion and expression analyses in uterine leiomyomata”. Cancer Genet. Cytogenet. 137 (2): 133\u2013137. doi:10.1016\/S0165-4608(02)00547-2. PMID\u00a012393284.Steiglitz BM, Keene DR, Greenspan DS (2003). “PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1”. J. Biol. Chem. 277 (51): 49820\u201349830. doi:10.1074\/jbc.M209891200. PMID\u00a012393877.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u201316903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Bernocco S, Steiglitz BM, Svergun DI,  et\u00a0al. (2003). “Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein”. J. Biol. Chem. 278 (9): 7199\u20137205. doi:10.1074\/jbc.M210857200. PMID\u00a012486138.Liepinsh E, Banyai L, Pintacuda G,  et\u00a0al. (2003). “NMR structure of the netrin-like domain (NTR) of human type I procollagen C-proteinase enhancer defines structural consensus of NTR domains and assesses potential proteinase inhibitory activity and ligand binding”. J. Biol. Chem. 278 (28): 25982\u201325989. doi:10.1074\/jbc.M302734200. PMID\u00a012670942.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20132127. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Petropoulou V, Garrigue-Antar L, Kadler KE (2005). “Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1)”. J. Biol. Chem. 280 (24): 22616\u201322623. doi:10.1074\/jbc.M413468200. PMID\u00a015817489.Ge G, Zhang Y, Steiglitz BM, Greenspan DS (2006). “Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains”. J. Biol. Chem. 281 (16): 10786\u201310798. doi:10.1074\/jbc.M511111200. PMID\u00a016507574.Blanc G, Font B, Eichenberger D,  et\u00a0al. (2007). “Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity”. J. Biol. Chem. 282 (23): 16924\u201316933. doi:10.1074\/jbc.M701610200. PMID\u00a017446170.PDB gallery1uap: NMR structure of the NTR domain from human PCOLCE1       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/pcolce-wikipedia\/#breadcrumbitem","name":"PCOLCE – Wikipedia"}}]}]