[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/phosphatidylinositol-345-trisphosphate-5-phosphatase-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/phosphatidylinositol-345-trisphosphate-5-phosphatase-wikipedia\/","headline":"Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase – Wikipedia","name":"Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase – Wikipedia","description":"From Wikipedia, the free encyclopedia Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1D–myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase,[1][2][3][4][5] that","datePublished":"2022-06-28","dateModified":"2022-06-28","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","url":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","height":"","width":""},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/phosphatidylinositol-345-trisphosphate-5-phosphatase-wikipedia\/","about":["Wiki"],"wordCount":2835,"articleBody":"From Wikipedia, the free encyclopediaPhosphatidylinositol-3,4,5-trisphosphate 5-phosphatase (EC 3.1.3.86, SHIP, p150Ship) is an enzyme with systematic name 1-phosphatidyl-1D–myo-inositol-3,4,5-trisphosphate 5-phosphohydrolase,[1][2][3][4][5] that has two isoforms: SHIP1 (produced by the gene INPP5D) and SHIP2 (INPPL1).This enzyme catalyses the following chemical reaction1-phosphatidyl-1D–myo-inositol 3,4,5-trisphosphate + H2O \u21cc{displaystyle rightleftharpoons }1-phosphatidyl-1D–myo-inositol 3,4-bisphosphate + phosphateThis enzyme hydrolyses 1-phosphatidyl-1D–myo-inositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2.References[edit]^ Lioubin MN, Algate PA, Tsai S, Carlberg K, Aebersold A, Rohrschneider LR (May 1996). “p150Ship, a signal transduction molecule with inositol polyphosphate-5-phosphatase activity”. Genes & Development. 10 (9): 1084\u201395. doi:10.1101\/gad.10.9.1084. PMID\u00a08654924.^ Damen JE, Liu L, Rosten P, Humphries RK, Jefferson AB, Majerus PW, Krystal G (February 1996). “The 145-kDa protein induced to associate with Shc by multiple cytokines is an inositol tetraphosphate and phosphatidylinositol 3,4,5-triphosphate 5-phosphatase”. Proceedings of the National Academy of Sciences of the United States of America. 93 (4): 1689\u201393. doi:10.1073\/pnas.93.4.1689. PMC\u00a040003. PMID\u00a08643691.^ Giuriato S, Payrastre B, Drayer AL, Plantavid M, Woscholski R, Parker P, Erneux C, Chap H (October 1997). “Tyrosine phosphorylation and relocation of SHIP are integrin-mediated in thrombin-stimulated human blood platelets”. The Journal of Biological Chemistry. 272 (43): 26857\u201363. doi:10.1074\/jbc.272.43.26857. PMID\u00a09341117.^ Drayer AL, Pesesse X, De Smedt F, Woscholski R, Parker P, Erneux C (August 1996). “Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase”. Biochemical and Biophysical Research Communications. 225 (1): 243\u20139. doi:10.1006\/bbrc.1996.1161. PMID\u00a08769125.^ Pesesse X, Moreau C, Drayer AL, Woscholski R, Parker P, Erneux C (October 1998). “The SH2 domain containing inositol 5-phosphatase SHIP2 displays phosphatidylinositol 3,4,5-trisphosphate and inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity”. FEBS Letters. 437 (3): 301\u20133. doi:10.1016\/S0014-5793(98)01255-1. 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