[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/plcb3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/plcb3-wikipedia\/","headline":"PLCB3 – Wikipedia","name":"PLCB3 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens 1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in","datePublished":"2019-01-16","dateModified":"2019-01-16","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/plcb3-wikipedia\/","about":["Wiki"],"wordCount":5462,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiens1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-3 is an enzyme that in humans is encoded by the PLCB3 gene.[5][6]The gene codes for the enzyme phospholipase C \u03b23. The enzyme catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11, as well as G-beta gamma subunits.Interactions[edit]PLCB3 has been shown to interact with Sodium-hydrogen exchange regulatory cofactor 2.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000149782 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024960 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Weber G, Friedman E, Grimmond S, Hayward NK, Phelan C, Skogseid B, Gobl A, Zedenius J, Sandelin K, Teh BT (March 1995). “The phospholipase C beta 3 gene located in the MEN1 region shows loss of expression in endocrine tumours”. Hum. Mol. Genet. 3 (10): 1775\u201381. doi:10.1093\/hmg\/3.10.1775. PMID\u00a07849701.^ “Entrez Gene: PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)”.^ Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG (June 2000). “Regulation of phospholipase C-beta 3 activity by Na+\/H+ exchanger regulatory factor 2”. J. Biol. Chem. 275 (22): 16632\u20137. doi:10.1074\/jbc.M001410200. PMID\u00a010748023.Further reading[edit]Carozzi AJ, Kriz RW, Webster C, Parker PJ (1992). “Identification, purification and characterization of a novel phosphatidylinositol-specific phospholipase C, a third member of the beta subfamily”. Eur. J. Biochem. 210 (2): 521\u20139. doi:10.1111\/j.1432-1033.1992.tb17450.x. PMID\u00a01333955.Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (1990). “Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3\/T cell-antigen receptor phosphoinositide transduction pathway”. J. Clin. Invest. 86 (6): 2117\u201324. doi:10.1172\/JCI114950. PMC\u00a0329852. PMID\u00a01979339.Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (1995). “Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line”. Eur. J. Immunol. 25 (9): 2695\u2013700. doi:10.1002\/eji.1830250944. PMID\u00a07589147. S2CID\u00a020562627.Lagercrantz J, Carson E, Phelan C, Grimmond S, Ros\u00e9n A, Dar\u00e9 E, Nordenskj\u00f6ld M, Hayward NK, Larsson C, Weber G (1995). “Genomic organization and complete cDNA sequence of the human phosphoinositide-specific phospholipase C beta 3 gene (PLCB3)”. Genomics. 26 (3): 467\u201372. doi:10.1016\/0888-7543(95)80164-H. PMID\u00a07607669.Mazuruk K, Schoen TJ, Chader GJ, Rodriguez IR (1995). “Structural organization and expression of the human phosphatidylinositol-specific phospholipase C beta-3 gene”. Biochem. Biophys. Res. Commun. 212 (1): 190\u20135. doi:10.1006\/bbrc.1995.1955. PMID\u00a07612006.Sinke RJ, Geurts van Kessel AG (1995). “Localization of the human phosphatidylinositol-specific phospholipase c beta 3 gene (PLCB3) within chromosome band 11q13”. Genomics. 25 (2): 568\u20139. doi:10.1016\/0888-7543(95)80060-Y. PMID\u00a07789993.Chen P, Mayne M, Power C, Nath A (1997). “The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases”. J. Biol. Chem. 272 (36): 22385\u20138. doi:10.1074\/jbc.272.36.22385. PMID\u00a09278385.Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP (1998). “GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95\/Dlg\/ZO-1) domain”. J. Biol. Chem. 273 (28): 17749\u201355. doi:10.1074\/jbc.273.28.17749. PMID\u00a09651375.Wang S, Zhou Y, Lukinius A, Oberg K, Skogseid B, Gobl A (1998). “Molecular cloning and characterization of a cDNA encoding mouse phospholipase C-beta3”. Biochim. Biophys. Acta. 1393 (1): 173\u20138. doi:10.1016\/s0005-2760(98)00074-5. PMID\u00a09714794.Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). “HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease”. Neuroimmunomodulation. 5 (3\u20134): 184\u201392. doi:10.1159\/000026336. PMID\u00a09730685. S2CID\u00a019529677.Haughey NJ, Holden CP, Nath A, Geiger JD (1999). “Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat”. J. Neurochem. 73 (4): 1363\u201374. doi:10.1046\/j.1471-4159.1999.0731363.x. PMID\u00a010501179. S2CID\u00a025410140.Hwang JI, Heo K, Shin KJ, Kim E, Yun C, Ryu SH, Shin HS, Suh PG (2000). “Regulation of phospholipase C-beta 3 activity by Na+\/H+ exchanger regulatory factor 2”. J. Biol. Chem. 275 (22): 16632\u20137. doi:10.1074\/jbc.M001410200. PMID\u00a010748023.Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK (2000). “Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta”. J. Biol. Chem. 275 (24): 18418\u201323. doi:10.1074\/jbc.M910211199. PMID\u00a010748198.Mayne M, Holden CP, Nath A, Geiger JD (2000). “Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages”. J. Immunol. 164 (12): 6538\u201342. doi:10.4049\/jimmunol.164.12.6538. PMID\u00a010843712.Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (2000). “Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)”. Biochim. Biophys. Acta. 1517 (1): 63\u201372. doi:10.1016\/S0167-4781(00)00260-8. PMID\u00a011118617.St\u00e5lberg P, Lopez-Egido JR, Wang S, Gobl A, Oberg K, Skogseid B (2001). “Differentially expressed cDNAs in PLCbeta3-induced tumor suppression in a human endocrine pancreatic tumor cell line: activation of the human mismatch repair protein 3 gene”. Biochem. Biophys. Res. Commun. 281 (1): 227\u201331. doi:10.1006\/bbrc.2001.4329. PMID\u00a011178984.Xia C, Bao Z, Yue C, Sanborn BM, Liu M (2001). “Phosphorylation and regulation of G-protein-activated phospholipase C-beta 3 by cGMP-dependent protein kinases”. J. Biol. Chem. 276 (23): 19770\u20137. doi:10.1074\/jbc.M006266200. PMID\u00a011278298.Yue C, Sanborn BM (2001). “KN-93 inhibition of G protein signaling is independent of the ability of Ca2+\/calmodulin-dependent protein kinase II to phosphorylate phospholipase Cbeta3 on 537-Ser”. Mol. Cell. Endocrinol. 175 (1\u20132): 149\u201356. doi:10.1016\/S0303-7207(01)00383-5. PMID\u00a011325525. S2CID\u00a0338776.Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (2002). “Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha”. Virology. 303 (1): 174\u201380. doi:10.1006\/viro.2002.1676. PMID\u00a012482669.  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