[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/plekho1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/plekho1-wikipedia\/","headline":"PLEKHO1 – Wikipedia","name":"PLEKHO1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Pleckstrin homology domain-containing family O member","datePublished":"2022-07-02","dateModified":"2022-07-02","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/plekho1-wikipedia\/","wordCount":4910,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensPleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the PLEKHO1 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Interactions[edit]PLEKHO1 has been shown to interact with Casein kinase 2, alpha 1[5] and SMURF1.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000023902 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015745 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b Bosc DG, Graham KC, Saulnier RB, Zhang C, Prober D, Gietz RD, Litchfield DW (May 2000). “Identification and characterization of CKIP-1, a novel pleckstrin homology domain-containing protein that interacts with protein kinase CK2”. The Journal of Biological Chemistry. 275 (19): 14295\u2013306. doi:10.1074\/jbc.275.19.14295. PMID\u00a010799509.^ “Entrez Gene: PLEKHO1 pleckstrin homology domain containing, family O member 1”.^ Lu K, Yin X, Weng T, Xi S, Li L, Xing G, Cheng X, Yang X, Zhang L, He F (August 2008). “Targeting WW domains linker of HECT-type ubiquitin ligase Smurf1 for activation by CKIP-1”. Nature Cell Biology. 10 (8): 994\u20131002. doi:10.1038\/ncb1760. PMID\u00a018641638. S2CID\u00a019216909.Further reading[edit]Maruyama K, Sugano S (January 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Hartley JL, Temple GF, Brasch MA (November 2000). “DNA cloning using in vitro site-specific recombination”. Genome Research. 10 (11): 1788\u201395. doi:10.1101\/gr.143000. PMC\u00a0310948. PMID\u00a011076863.Olsten ME, Canton DA, Zhang C, Walton PA, Litchfield DW (October 2004). “The Pleckstrin homology domain of CK2 interacting protein-1 is required for interactions and recruitment of protein kinase CK2 to the plasma membrane”. The Journal of Biological Chemistry. 279 (40): 42114\u201327. doi:10.1074\/jbc.M407628200. PMID\u00a015254037.Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, S\u00fcltmann H, Poustka A (October 2004). “From ORFeome to biology: a functional genomics pipeline”. Genome Research. 14 (10B): 2136\u201344. doi:10.1101\/gr.2576704. PMC\u00a0528930. PMID\u00a015489336.Zhang L, Xing G, Tie Y, Tang Y, Tian C, Li L, Sun L, Wei H, Zhu Y, He F (February 2005). “Role for the pleckstrin homology domain-containing protein CKIP-1 in AP-1 regulation and apoptosis”. The EMBO Journal. 24 (4): 766\u201378. doi:10.1038\/sj.emboj.7600532. PMC\u00a0549613. PMID\u00a015706351.Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). “High-throughput mapping of a dynamic signaling network in mammalian cells”. Science. 307 (5715): 1621\u20135. Bibcode:2005Sci…307.1621B. doi:10.1126\/science.1105776. PMID\u00a015761153. S2CID\u00a039457788.Canton DA, Olsten ME, Kim K, Doherty-Kirby A, Lajoie G, Cooper JA, Litchfield DW (May 2005). “The pleckstrin homology domain-containing protein CKIP-1 is involved in regulation of cell morphology and the actin cytoskeleton and interaction with actin capping protein”. Molecular and Cellular Biology. 25 (9): 3519\u201334. doi:10.1128\/MCB.25.9.3519-3534.2005. PMC\u00a01084316. PMID\u00a015831458.Zhang L, Tie Y, Tian C, Xing G, Song Y, Zhu Y, Sun Z, He F (September 2006). “CKIP-1 recruits nuclear ATM partially to the plasma membrane through interaction with ATM”. Cellular Signalling. 18 (9): 1386\u201395. doi:10.1016\/j.cellsig.2005.10.017. PMID\u00a016325375.Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (January 2006). “The LIFEdb database in 2006”. Nucleic Acids Research. 34 (Database issue): D415-8. doi:10.1093\/nar\/gkj139. PMC\u00a01347501. PMID\u00a016381901.Lim J, Hao T, Shaw C, Patel AJ, Szab\u00f3 G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barab\u00e1si AL, Vidal M, Zoghbi HY (May 2006). “A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration”. Cell. 125 (4): 801\u201314. doi:10.1016\/j.cell.2006.03.032. PMID\u00a016713569. S2CID\u00a013709685.Canton DA, Olsten ME, Niederstrasser H, Cooper JA, Litchfield DW (November 2006). “The role of CKIP-1 in cell morphology depends on its interaction with actin-capping protein”. The Journal of Biological Chemistry. 281 (47): 36347\u201359. doi:10.1074\/jbc.M607595200. PMC\u00a02583070. PMID\u00a016987810.Zhang L, Tang Y, Tie Y, Tian C, Wang J, Dong Y, Sun Z, He F (May 2007). “The PH domain containing protein CKIP-1 binds to IFP35 and Nmi and is involved in cytokine signaling”. Cellular Signalling. 19 (5): 932\u201344. doi:10.1016\/j.cellsig.2006.11.002. PMID\u00a017197158.Tokuda E, Fujita N, Oh-hara T, Sato S, Kurata A, Katayama R, Itoh T, Takenawa T, Miyazono K, Tsuruo T (October 2007). “Casein kinase 2-interacting protein-1, a novel Akt pleckstrin homology domain-interacting protein, down-regulates PI3K\/Akt signaling and suppresses tumor growth in vivo”. Cancer Research. 67 (20): 9666\u201376. doi:10.1158\/0008-5472.CAN-07-1050. PMID\u00a017942896.       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