[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/plk3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/plk3-wikipedia\/","headline":"PLK3 &#8211; Wikipedia","name":"PLK3 &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Polo-like kinase 3 (Drosophila), also known","datePublished":"2018-04-12","dateModified":"2018-04-12","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/plk3-wikipedia\/","wordCount":6399,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensPolo-like kinase 3 (Drosophila), also known as PLK3, is an enzyme which in humans is encoded by the PLK3 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]Cytokine-inducible kinase is a putative serine\/threonine kinase.  CNK contains both a catalytic domain and a putative regulatory domain.  It may play a role in regulation of cell cycle progression and tumorigenesis.[5]Interactions[edit]PLK3 has been shown to interact with:       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000173846 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028680 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b &#8220;Entrez Gene: PLK3 polo-like kinase 3 (Drosophila)&#8221;.^ Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (August 1996). &#8220;Prk, a cytokine-inducible human protein serine\/threonine kinase whose expression appears to be down-regulated in lung carcinomas&#8221;. J. Biol. Chem. 271 (32): 19402\u20138. doi:10.1074\/jbc.271.32.19402. PMID\u00a08702627.^ Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (Oct 1999). &#8220;The physical association and phosphorylation of Cdc25C protein phosphatase by Prk&#8221;. Oncogene. 18 (44): 6029\u201336. doi:10.1038\/sj.onc.1202983. PMID\u00a010557092.^ a b Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (Sep 2002). &#8220;Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways&#8221;. Oncogene. 21 (43): 6633\u201340. doi:10.1038\/sj.onc.1205850. PMID\u00a012242661.^ Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (Nov 2001). &#8220;Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway&#8221;. J. Biol. Chem. 276 (46): 43305\u201312. doi:10.1074\/jbc.M106050200. PMID\u00a011551930.Further reading[edit]Li B, Ouyang B, Pan H, Reissmann PT, Slamon DJ, Arceci R, Lu L, Dai W (1996). &#8220;Prk, a cytokine-inducible human protein serine\/threonine kinase whose expression appears to be down-regulated in lung carcinomas&#8221;. J. Biol. Chem. 271 (32): 19402\u20138. doi:10.1074\/jbc.271.32.19402. PMID\u00a08702627.Peng CY, Graves PR, Thoma RS, Wu Z, Shaw AS, Piwnica-Worms H (1997). &#8220;Mitotic and G2 checkpoint control: regulation of 14-3-3 protein binding by phosphorylation of Cdc25C on serine-216&#8221;. Science. 277 (5331): 1501\u20135. doi:10.1126\/science.277.5331.1501. PMID\u00a09278512.Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W (1997). &#8220;Human Prk is a conserved protein serine\/threonine kinase involved in regulating M phase functions&#8221;. J. Biol. Chem. 272 (45): 28646\u201351. doi:10.1074\/jbc.272.45.28646. PMID\u00a09353331.Kauselmann G, Weiler M, Wulff P, Jessberger S, Konietzko U, Scafidi J, Staubli U, Bereiter-Hahn J, Strebhardt K, Kuhl D (1999). &#8220;The polo-like protein kinases Fnk and Snk associate with a Ca(2+)- and integrin-binding protein and are regulated dynamically with synaptic plasticity&#8221;. EMBO J. 18 (20): 5528\u201339. doi:10.1093\/emboj\/18.20.5528. PMC\u00a01171621. PMID\u00a010523297.Ouyang B, Li W, Pan H, Meadows J, Hoffmann I, Dai W (1999). &#8220;The physical association and phosphorylation of Cdc25C protein phosphatase by Prk&#8221;. Oncogene. 18 (44): 6029\u201336. doi:10.1038\/sj.onc.1202983. PMID\u00a010557092.Shieh SY, Ahn J, Tamai K, Taya Y, Prives C (2000). &#8220;The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites&#8221;. Genes Dev. 14 (3): 289\u2013300. doi:10.1101\/gad.14.3.289. PMC\u00a0316358. PMID\u00a010673501.Dai W, Li Y, Ouyang B, Pan H, Reissmann P, Li J, Wiest J, Stambrook P, Gluckman JL, Noffsinger A, Bejarano P (2000). &#8220;PRK, a cell cycle gene localized to 8p21, is downregulated in head and neck cancer&#8221;. Genes Chromosomes Cancer. 27 (3): 332\u20136. doi:10.1002\/(SICI)1098-2264(200003)27:33.0.CO;2-K. PMID\u00a010679924. S2CID\u00a020642025.Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000). &#8220;Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro&#8221;. Proc. Natl. Acad. Sci. U.S.A. 97 (19): 10389\u201394. Bibcode:2000PNAS&#8230;9710389M. doi:10.1073\/pnas.190030497. PMC\u00a027034. PMID\u00a010973490.Holtrich U, Wolf G, Yuan J, Bereiter-Hahn J, Karn T, Weiler M, Kauselmann G, Rehli M, Andreesen R, Kaufmann M, Kuhl D, Strebhardt K (2000). &#8220;Adhesion induced expression of the serine\/threonine kinase Fnk in human macrophages&#8221;. Oncogene. 19 (42): 4832\u20139. doi:10.1038\/sj.onc.1203845. PMID\u00a011039900.Bulavin DV, Higashimoto Y, Popoff IJ, Gaarde WA, Basrur V, Potapova O, Appella E, Fornace AJ (2001). &#8220;Initiation of a G2\/M checkpoint after ultraviolet radiation requires p38 kinase&#8221;. Nature. 411 (6833): 102\u20137. Bibcode:2001Natur.411..102B. doi:10.1038\/35075107. PMID\u00a011333986. S2CID\u00a04410763.Xie S, Wu H, Wang Q, Cogswell JP, Husain I, Conn C, Stambrook P, Jhanwar-Uniyal M, Dai W (2001). &#8220;Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathway&#8221;. J. Biol. Chem. 276 (46): 43305\u201312. doi:10.1074\/jbc.M106050200. PMID\u00a011551930.Latonen L, Taya Y, Laiho M (2001). &#8220;UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts&#8221;. Oncogene. 20 (46): 6784\u201393. doi:10.1038\/sj.onc.1204883. PMID\u00a011709713.Ahn JY, Li X, Davis HL, Canman CE (2002). &#8220;Phosphorylation of threonine 68 promotes oligomerization and autophosphorylation of the Chk2 protein kinase via the forkhead-associated domain&#8221;. J. Biol. Chem. 277 (22): 19389\u201395. doi:10.1074\/jbc.M200822200. PMID\u00a011901158.Sumara I, Vorlaufer E, Stukenberg PT, Kelm O, Redemann N, Nigg EA, Peters JM (2002). &#8220;The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase&#8221;. Mol. Cell. 9 (3): 515\u201325. doi:10.1016\/S1097-2765(02)00473-2. PMID\u00a011931760.Wang Q, Xie S, Chen J, Fukasawa K, Naik U, Traganos F, Darzynkiewicz Z, Jhanwar-Uniyal M, Dai W (2002). &#8220;Cell cycle arrest and apoptosis induced by human Polo-like kinase 3 is mediated through perturbation of microtubule integrity&#8221;. Mol. Cell. Biol. 22 (10): 3450\u20139. doi:10.1128\/MCB.22.10.3450-3459.2002. PMC\u00a0133784. PMID\u00a011971976.Bahassi el M, Conn CW, Myer DL, Hennigan RF, McGowan CH, Sanchez Y, Stambrook PJ (2002). &#8220;Mammalian Polo-like kinase 3 (Plk3) is a multifunctional protein involved in stress response pathways&#8221;. Oncogene. 21 (43): 6633\u201340. doi:10.1038\/sj.onc.1205850. PMID\u00a012242661.Tsvetkov L, Xu X, Li J, Stern DF (2003). &#8220;Polo-like kinase 1 and Chk2 interact and co-localize to centrosomes and the midbody&#8221;. J. Biol. Chem. 278 (10): 8468\u201375. doi:10.1074\/jbc.M211202200. PMID\u00a012493754.Xie S, Wu H, Wang Q, Kunicki J, Thomas RO, Hollingsworth RE, Cogswell J, Dai W (2003). &#8220;Genotoxic stress-induced activation of Plk3 is partly mediated by Chk2&#8221;. Cell Cycle. 1 (6): 424\u20139. doi:10.4161\/cc.1.6.271. PMID\u00a012548019.Bahassi el M, Hennigan RF, Myer DL, Stambrook PJ (2004). &#8220;Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation&#8221;. Oncogene. 23 (15): 2658\u201363. doi:10.1038\/sj.onc.1207425. 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