[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/ppan-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/ppan-wikipedia\/","headline":"PPAN &#8211; Wikipedia","name":"PPAN &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Suppressor of SWI4 1 homolog is","datePublished":"2016-12-22","dateModified":"2016-12-22","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","height":"101","width":"135"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/ppan-wikipedia\/","about":["Wiki"],"wordCount":5477,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensSuppressor of SWI4 1 homolog is a protein that in humans is encoded by the PPAN gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The protein encoded by this gene is an evolutionarily conserved protein similar to yeast SSF1 as well as to the gene product of the Drosophila gene peter pan (PPAN). SSF1 is known to be involved in the second step of mRNA splicing. Both SSF1 and PPAN are essential for cell growth and proliferation. This gene was found to cotranscript with P2RY11\/P2Y(11), an immediate downstream gene on the chromosome that encodes an ATP receptor. The chimeric transcripts of this gene and P2RY11 were found to be ubiquitously present and regulated during granulocytic differentiation. Exogenous expression of this gene was reported to reduce the anchorage-independent growth of some tumor cells.[6]Although being involved in ribosome biogenesis, human PPAN is not merely localized in nucleoli, but also in mitochondria. Depletion of PPAN provokes apoptosis as observed by increased amounts of p53 and its target gene p21, BAX-driven depolarisation of mitochondria, cytochrome c release as well as caspase-dependent cleavage of PARP.[7] Recent studies revealed that PPAN participates in the regulation of mitochondrial homeostasis, presumably via modulation of autophagy.[8] Furthermore, PPAN is required for proper cycling of cells since down regulation of PPAN in cancer cells results in a p53-independent cell cycle arrest.[9]One of the introns of PPAN encodes the Small nucleolar RNA SNORD105.[10]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000130810 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000004100 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Welch PJ, Marcusson EG, Li QX, Beger C, Kr\u00fcger M, Zhou C,  et\u00a0al. (June 2000). &#8220;Identification and validation of a gene involved in anchorage-independent cell growth control using a library of randomized hairpin ribozymes&#8221;. Genomics. 66 (3): 274\u201383. doi:10.1006\/geno.2000.6230. PMID\u00a010873382.^ a b &#8220;Entrez Gene: PPAN peter pan homolog (Drosophila)&#8221;.^ Pfister AS, Keil M, K\u00fchl M (April 2015). &#8220;The Wnt Target Protein Peter Pan Defines a Novel p53-independent Nucleolar Stress-Response Pathway&#8221;. The Journal of Biological Chemistry. 290 (17): 10905\u201318. doi:10.1074\/jbc.M114.634246. PMC\u00a04409253. PMID\u00a025759387.^ Dannheisig, David P.; Beck, Eileen; Calzia, Enrico; Walther, Paul; Behrends, Christian; Pfister, Astrid S. (2019). &#8220;Loss of Peter Pan (PPAN) Affects Mitochondrial Homeostasis and Autophagic Flux&#8221;. Cells. 8 (8): 894. doi:10.3390\/cells8080894. PMC\u00a06721654. PMID\u00a031416196.^ Keil M, Meyer MT, Dannheisig DP, Maerz LD, Philipp M, Pfister AS (May 2019). &#8220;Loss of Peter Pan protein is associated with cell cycle defects and apoptotic events&#8221;. Biochimica et Biophysica Acta (BBA) &#8211; Molecular Cell Research. 1866 (5): 882\u2013895. doi:10.1016\/j.bbamcr.2019.01.010. PMID\u00a030716409.^ Vitali P, Royo H, Seitz H, Bachellerie JP, H\u00fcttenhofer A, Cavaill\u00e9 J (November 2003). &#8220;Identification of 13 novel human modification guide RNAs&#8221;. Nucleic Acids Research. 31 (22): 6543\u201351. doi:10.1093\/nar\/gkg849. PMC\u00a0275545. PMID\u00a014602913.Further reading[edit]Communi D, Govaerts C, Parmentier M, Boeynaems JM (December 1997). &#8220;Cloning of a human purinergic P2Y receptor coupled to phospholipase C and adenylyl cyclase&#8221;. The Journal of Biological Chemistry. 272 (51): 31969\u201373. doi:10.1074\/jbc.272.51.31969. PMID\u00a09405388.Migeon JC, Garfinkel MS, Edgar BA (June 1999). &#8220;Cloning and characterization of peter pan, a novel Drosophila gene required for larval growth&#8221;. Molecular Biology of the Cell. 10 (6): 1733\u201344. doi:10.1091\/mbc.10.6.1733. PMC\u00a025365. PMID\u00a010359593.Suarez-Huerta N, Boeynaems JM, Communi D (August 2000). &#8220;Cloning, genomic organization, and tissue distribution of human Ssf-1&#8221;. Biochemical and Biophysical Research Communications. 275 (1): 37\u201342. doi:10.1006\/bbrc.2000.3259. PMID\u00a010944437.Communi D, Suarez-Huerta N, Dussossoy D, Savi P, Boeynaems JM (May 2001). &#8220;Cotranscription and intergenic splicing of human P2Y11 and SSF1 genes&#8221;. The Journal of Biological Chemistry. 276 (19): 16561\u20136. doi:10.1074\/jbc.M009609200. PMID\u00a011278528.Andersen JS, Lyon CE, Fox AH, Leung AK, Lam YW, Steen H,  et\u00a0al. (January 2002). &#8220;Directed proteomic analysis of the human nucleolus&#8221;. Current Biology. 12 (1): 1\u201311. doi:10.1016\/S0960-9822(01)00650-9. PMID\u00a011790298. S2CID\u00a014132033.Duhant X, Schanden\u00e9 L, Bruyns C, Gonzalez NS, Goldman M, Boeynaems JM, Communi D (July 2002). &#8220;Extracellular adenine nucleotides inhibit the activation of human CD4+ T lymphocytes&#8221;. Journal of Immunology. 169 (1): 15\u201321. doi:10.4049\/jimmunol.169.1.15. PMID\u00a012077223.Scherl A, Cout\u00e9 Y, D\u00e9on C, Call\u00e9 A, Kindbeiter K, Sanchez JC,  et\u00a0al. (November 2002). &#8220;Functional proteomic analysis of human nucleolus&#8221;. Molecular Biology of the Cell. 13 (11): 4100\u20139. doi:10.1091\/mbc.E02-05-0271. PMC\u00a0133617. PMID\u00a012429849.Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Vill\u00e9n J, Li J,  et\u00a0al. (August 2004). &#8220;Large-scale characterization of HeLa cell nuclear phosphoproteins&#8221;. Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130\u20135. Bibcode:2004PNAS..10112130B. doi:10.1073\/pnas.0404720101. PMC\u00a0514446. PMID\u00a015302935.Nousiainen M, Sillj\u00e9 HH, Sauer G, Nigg EA, K\u00f6rner R (April 2006). &#8220;Phosphoproteome analysis of the human mitotic spindle&#8221;. Proceedings of the National Academy of Sciences of the United States of America. 103 (14): 5391\u20136. Bibcode:2006PNAS..103.5391N. doi:10.1073\/pnas.0507066103. PMC\u00a01459365. PMID\u00a016565220.Beausoleil SA, Vill\u00e9n J, Gerber SA, Rush J, Gygi SP (October 2006). &#8220;A probability-based approach for high-throughput protein phosphorylation analysis and site localization&#8221;. Nature Biotechnology. 24 (10): 1285\u201392. doi:10.1038\/nbt1240. PMID\u00a016964243. S2CID\u00a014294292.Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). &#8220;Global, in vivo, and site-specific phosphorylation dynamics in signaling networks&#8221;. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983. S2CID\u00a07827573.Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S,  et\u00a0al. (2007). &#8220;Large-scale mapping of human protein-protein interactions by mass spectrometry&#8221;. Molecular Systems Biology. 3 (1): 89. doi:10.1038\/msb4100134. PMC\u00a01847948. PMID\u00a017353931.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Wikimedia ErrorOur servers are currently under maintenance or experiencing a technical problem.Please try again in a few\u00a0minutes.See the error message at the bottom of this page for more\u00a0information.      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