[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/ppt2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/ppt2-wikipedia\/","headline":"PPT2 – Wikipedia","name":"PPT2 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Lysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase","datePublished":"2017-02-02","dateModified":"2017-02-02","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/ppt2-wikipedia\/","wordCount":5352,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensLysosomal thioesterase PPT2 (PPT-2), also known as S-thioesterase G14, is an enzyme that in humans is encoded by the PPT2 gene.[5][6][7]Function[edit]This gene encodes a member of the palmitoyl protein thioesterase family. The encoded glycosylated lysosomal protein has palmitoyl-CoA hydrolase activity in vitro, but does not hydrolyze palmitate from cysteine residues in proteins.[5]References[edit]^ a b c ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 GRCh38: Ensembl release 89: ENSG00000227600, ENSG00000231618, ENSG00000168452, ENSG00000228116, ENSG00000236649, ENSG00000206256, ENSG00000206329, ENSG00000221988 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000015474 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: palmitoyl-protein thioesterase 2”.^ Soyombo AA, Hofmann SL (October 1997). “Molecular cloning and expression of palmitoyl-protein thioesterase 2 (PPT2), a homolog of lysosomal palmitoyl-protein thioesterase with a distinct substrate specificity”. J. Biol. Chem. 272 (43): 27456\u201363. doi:10.1074\/jbc.272.43.27456. PMID\u00a09341199.^ Soyombo AA, Yi W, Hofmann SL (March 1999). “Structure of the human palmitoyl-protein thioesterase-2 gene (PPT2) in the major histocompatibility complex on chromosome 6p21.3”. Genomics. 56 (2): 208\u201316. doi:10.1006\/geno.1998.5703. PMID\u00a010051407.Further reading[edit]Gupta P, Soyombo AA, Atashband A,  et\u00a0al. (2001). “Disruption of PPT1 or PPT2 causes neuronal ceroid lipofuscinosis in knockout mice”. Proc. Natl. Acad. Sci. U.S.A. 98 (24): 13566\u201371. Bibcode:2001PNAS…9813566G. doi:10.1073\/pnas.251485198. PMC\u00a061081. PMID\u00a011717424.Aguado B, Campbell RD (1999). “Characterization of a human MHC class III region gene product with S-thioesterase activity”. Biochem. J. 341 ( Pt 3) (Pt 3): 679\u201389. doi:10.1042\/bj3410679. PMC\u00a01220406. PMID\u00a010417332.Simpson JC, Wellenreuther R, Poustka A,  et\u00a0al. (2000). “Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing”. EMBO Rep. 1 (3): 287\u201392. doi:10.1093\/embo-reports\/kvd058. PMC\u00a01083732. PMID\u00a011256614.Hancock DB, Eijgelsheim M, Wilk JB,  et\u00a0al. (2010). “Meta-analyses of genome-wide association studies identify multiple novel loci associated with pulmonary function”. Nat. Genet. 42 (1): 45\u201352. doi:10.1038\/ng.500. PMC\u00a02832852. PMID\u00a020010835.Wiemann S, Weil B, Wellenreuther R,  et\u00a0al. (2001). “Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs”. Genome Res. 11 (3): 422\u201335. doi:10.1101\/gr.GR1547R. PMC\u00a0311072. PMID\u00a011230166.Calero G, Gupta P, Nonato MC,  et\u00a0al. (2003). “The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2”. J. Biol. Chem. 278 (39): 37957\u201364. doi:10.1074\/jbc.M301225200. PMID\u00a012855696.Mungall AJ, Palmer SA, Sims SK,  et\u00a0al. (2003). “The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805\u201311. Bibcode:2003Natur.425..805M. doi:10.1038\/nature02055. PMID\u00a014574404.Barcellos LF, May SL, Ramsay PP,  et\u00a0al. (2009).  Roopenian DC (ed.). “High-Density SNP Screening of the Major Histocompatibility Complex in Systemic Lupus Erythematosus Demonstrates Strong Evidence for Independent Susceptibility Regions”. PLOS Genet. 5 (10): e1000696. doi:10.1371\/journal.pgen.1000696. PMC\u00a02758598. PMID\u00a019851445.McKinnon E, Morahan G, Nolan D,  et\u00a0al. (2009). “Association of MHC SNP genotype with susceptibility to type 1 diabetes: a modified survival approach”. Diabetes Obes Metab. 11 (Suppl 1): 92\u2013100. doi:10.1111\/j.1463-1326.2008.01009.x. PMC\u00a02755510. PMID\u00a019143821.Mehrle A, Rosenfelder H, Schupp I,  et\u00a0al. (2006). “The LIFEdb database in 2006”. Nucleic Acids Res. 34 (Database issue): D415\u20138. doi:10.1093\/nar\/gkj139. PMC\u00a01347501. PMID\u00a016381901.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Xie T, Rowen L, Aguado B,  et\u00a0al. (2003). “Analysis of the Gene-Dense Major Histocompatibility Complex Class III Region and Its Comparison to Mouse”. Genome Res. 13 (12): 2621\u201336. doi:10.1101\/gr.1736803. PMC\u00a0403804. PMID\u00a014656967.Hartley JL, Temple GF, Brasch MA (2000). “DNA Cloning Using In Vitro Site-Specific Recombination”. Genome Res. 10 (11): 1788\u201395. doi:10.1101\/gr.143000. PMC\u00a0310948. PMID\u00a011076863.Clark HF, Gurney AL, Abaya E,  et\u00a0al. (2003). “The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment”. Genome Res. 13 (10): 2265\u201370. doi:10.1101\/gr.1293003. PMC\u00a0403697. PMID\u00a012975309.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2002). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Wiemann S, Arlt D, Huber W,  et\u00a0al. (2004). “From ORFeome to Biology: A Functional Genomics Pipeline”. Genome Res. 14 (10B): 2136\u201344. doi:10.1101\/gr.2576704. PMC\u00a0528930. PMID\u00a015489336.Hillman RT, Green RE, Brenner SE (2004). “An unappreciated role for RNA surveillance”. Genome Biol. 5 (2): R8. doi:10.1186\/gb-2004-5-2-r8. PMC\u00a0395752. PMID\u00a014759258.This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/ppt2-wikipedia\/#breadcrumbitem","name":"PPT2 – Wikipedia"}}]}]