[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/prim2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/prim2-wikipedia\/","headline":"PRIM2 – Wikipedia","name":"PRIM2 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens DNA primase large subunit is an enzyme that","datePublished":"2016-12-02","dateModified":"2016-12-02","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/prim2-wikipedia\/","about":["Wiki"],"wordCount":3368,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensDNA primase large subunit is an enzyme that in humans is encoded by the PRIM2 gene.[5][6]The replication of DNA in eukaryotic cells is carried out by a complex chromosomal replication apparatus, in which DNA polymerase alpha and primase are two key enzymatic components. Primase, which is a heterodimer of a small subunit and a large subunit, synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. The protein encoded by this gene is the large, 58 kDa primase subunit.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000146143 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026134 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Shiratori A, Okumura K, Nogami M, Taguchi H, Onozaki T, Inoue T, Ando T, Shibata T, Izumi M, Miyazawa H,  et\u00a0al. (Feb 1996). “Assignment of the 49-kDa (PRIM1) and 58-kDa (PRIM2A and PRIM2B) subunit genes of the human DNA primase to chromosome bands 1q44 and 6p11.1-p12”. Genomics. 28 (2): 350\u20133. doi:10.1006\/geno.1995.1155. PMID\u00a08530050.^ a b “Entrez Gene: PRIM2A primase, polypeptide 2A, 58kDa”.Further reading[edit]Stadlbauer F, Brueckner A, Rehfuess C,  et\u00a0al. (1994). “DNA replication in vitro by recombinant DNA-polymerase-alpha-primase”. Eur. J. Biochem. 222 (3): 781\u201393. doi:10.1111\/j.1432-1033.1994.tb18925.x. PMID\u00a08026492.Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K,  et\u00a0al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Coll JM, Hickey RJ, Cronkey EA,  et\u00a0al. (1998). “Mapping specific protein-protein interactions within the core component of the breast cell DNA synthesome”. Oncol. Res. 9 (11\u201312): 629\u201339. PMID\u00a09563011.Schneider A, Smith RW, Kautz AR,  et\u00a0al. (1998). “Primase activity of human DNA polymerase alpha-primase. Divalent cations stabilize the enzyme activity of the p48 subunit”. J. Biol. Chem. 273 (34): 21608\u201315. doi:10.1074\/jbc.273.34.21608. PMID\u00a09705292.Arezi B, Kirk BW, Copeland WC, Kuchta RD (1999). “Interactions of DNA with human DNA primase monitored with photoactivatable cross-linking agents: implications for the role of the p58 subunit”. Biochemistry. 38 (39): 12899\u2013907. doi:10.1021\/bi9908991. PMID\u00a010504261.Smith RW, Nasheuer HP (2002). “Control of complex formation of DNA polymerase alpha-primase and cell-free DNA replication by the C-terminal amino acids of the largest subunit p180”. FEBS Lett. 527 (1\u20133): 143\u20136. doi:10.1016\/S0014-5793(02)03197-6. PMID\u00a012220650. S2CID\u00a027852377.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Mungall AJ, Palmer SA, Sims SK,  et\u00a0al. (2003). “The DNA sequence and analysis of human chromosome 6”. Nature. 425 (6960): 805\u201311. Bibcode:2003Natur.425..805M. doi:10.1038\/nature02055. PMID\u00a014574404.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Rush J, Moritz A, Lee KA,  et\u00a0al. (2005). “Immunoaffinity profiling of tyrosine phosphorylation in cancer cells”. Nat. Biotechnol. 23 (1): 94\u2013101. doi:10.1038\/nbt1046. PMID\u00a015592455. S2CID\u00a07200157.External links[edit]PDBe-KB provides an overview of all the structure information available in the PDB for Human DNA primase large subunit (PRIM2)  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/prim2-wikipedia\/#breadcrumbitem","name":"PRIM2 – Wikipedia"}}]}]