[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/prkcb1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/prkcb1-wikipedia\/","headline":"PRKCB1 – Wikipedia","name":"PRKCB1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Protein kinase C beta type is","datePublished":"2014-06-06","dateModified":"2014-06-06","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/e\/ec\/PDB_1a25_EBI.jpg\/180px-PDB_1a25_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/e\/ec\/PDB_1a25_EBI.jpg\/180px-PDB_1a25_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/prkcb1-wikipedia\/","wordCount":3207,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensProtein kinase C beta type is an enzyme that in humans is encoded by the PRKCB gene.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase has been reported to be involved in many different cellular functions, such as B cell activation, apoptosis induction, endothelial cell proliferation, and intestinal sugar absorption. Studies in mice also suggest that this kinase may also regulate neuronal functions and correlate fear-induced conflict behavior after stress. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[6] This gene could be associated with autism.[7][8]Table of ContentsInteractions[edit]See also[edit]References[edit]Further reading[edit]Interactions[edit]PRKCB1 has been shown to interact with RIPK4,[9]beta adrenergic receptor kinase,[10]PDLIM5[11] and GNB2L1.[12]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000166501 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052889 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Kubo K, Ohno S, Suzuki K (September 1987). “Nucleotide sequence of the 3′ portion of a human gene for protein kinase C beta I\/beta II”. Nucleic Acids Research. 15 (17): 7179\u201380. doi:10.1093\/nar\/15.17.7179. PMC\u00a0306204. PMID\u00a03658678.^ “Entrez Gene: PRKCB1 protein kinase C, beta 1”.^ Philippi A, Roschmann E, Tores F, Lindenbaum P, Benajou A, Germain-Leclerc L,  et\u00a0al. (October 2005). “Haplotypes in the gene encoding protein kinase c-beta (PRKCB1) on chromosome 16 are associated with autism”. Molecular Psychiatry. 10 (10): 950\u201360. doi:10.1038\/sj.mp.4001704. PMID\u00a016027742.^ Lintas C, Sacco R, Garbett K, Mirnics K, Militerni R, Bravaccio C,  et\u00a0al. (July 2009). “Involvement of the PRKCB1 gene in autistic disorder: significant genetic association and reduced neocortical gene expression”. Molecular Psychiatry. 14 (7): 705\u201318. doi:10.1038\/mp.2008.21. PMID\u00a018317465.^ Chen L, Haider K, Ponda M, Cariappa A, Rowitch D, Pillai S (June 2001). “Protein kinase C-associated kinase (PKK), a novel membrane-associated, ankyrin repeat-containing protein kinase”. The Journal of Biological Chemistry. 276 (24): 21737\u201344. doi:10.1074\/jbc.M008069200. PMID\u00a011278382.^ Yang XL, Zhang YL, Lai ZS, Xing FY, Liu YH (April 2003). “Pleckstrin homology domain of G protein-coupled receptor kinase-2 binds to PKC and affects the activity of PKC kinase”. World Journal of Gastroenterology. 9 (4): 800\u20133. doi:10.3748\/wjg.v9.i4.800. PMC\u00a04611453. PMID\u00a012679936.^ Kuroda S, Tokunaga C, Kiyohara Y, Higuchi O, Konishi H, Mizuno K,  et\u00a0al. (December 1996). “Protein-protein interaction of zinc finger LIM domains with protein kinase C”. The Journal of Biological Chemistry. 271 (49): 31029\u201332. doi:10.1074\/jbc.271.49.31029. PMID\u00a08940095.^ Ron D, Jiang Z, Yao L, Vagts A, Diamond I, Gordon A (September 1999). “Coordinated movement of RACK1 with activated betaIIPKC”. The Journal of Biological Chemistry. 274 (38): 27039\u201346. doi:10.1074\/jbc.274.38.27039. PMID\u00a010480917.Further reading[edit]PDB gallery1a25: C2 DOMAIN FROM PROTEIN KINASE C (BETA)2i0e: Structure of catalytic domain of human protein kinase C beta II complexed with a bisindolylmaleimide inhibitor       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/prkcb1-wikipedia\/#breadcrumbitem","name":"PRKCB1 – Wikipedia"}}]}]