[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/prrx1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/prrx1-wikipedia\/","headline":"PRRX1 – Wikipedia","name":"PRRX1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Paired related homeobox 1 is a protein that","datePublished":"2022-08-15","dateModified":"2022-08-15","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/prrx1-wikipedia\/","about":["Wiki"],"wordCount":6172,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensPaired related homeobox 1 is a protein that in humans is encoded by the PRRX1 gene.[5][6]Table of ContentsFunction[edit]Role in mesenchymal stem cell differentiation[edit]References[edit]Further reading[edit]External links[edit]Function[edit]The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription coactivator, enhancing the DNA-binding activity of serum response factor, a protein required for the induction of genes by growth and differentiation factors. The protein regulates muscle creatine kinase, indicating a role in the establishment of diverse mesodermal muscle types. Alternative splicing yields two isoforms that differ in abundance and expression patterns.[6]Role in mesenchymal stem cell differentiation[edit]Prrx1 expression is restricted to the mesoderm during embryonic development, and both Prrx1 and Prrx2 are expressed in mesenchymal tissues in adult mice.[7][8][9][10][11] Mice that lack both Prrx1 and Prrx2 have profound defects in mesenchymal cell differentiation in the craniofacial region.[9][12] Several  recent studies demonstrate that PRRX1 can regulate differentiation of mesenchymal precursors. For example, PRRX1 inhibits adipogenesis by activating transforming growth factor-beta (TGF-beta) signaling,[13] and also acts downstream of tumor necrosis factor-alpha to inhibit osteoblast differentiation.[14]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000116132 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000026586 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Grueneberg DA, Natesan S, Alexandre C, Gilman MZ (Sep 1992). “Human and Drosophila homeodomain proteins that enhance the DNA-binding activity of serum response factor”. Science. 257 (5073): 1089\u201395. Bibcode:1992Sci…257.1089G. doi:10.1126\/science.257.5073.1089. PMID\u00a01509260. S2CID\u00a01206059.^ a b “Entrez Gene: PRRX1 paired related homeobox 1”.^ Kern MJ, Witte DP, Valerius MT, Aronow BJ, Potter SS (October 1992). “A novel murine homeobox gene isolated by a tissue specific PCR cloning strategy”. Nucleic Acids Res. 20 (19): 5189\u201395. doi:10.1093\/nar\/20.19.5189. PMC\u00a0334304. PMID\u00a01383943.^ Nohno T, Koyama E, Myokai F, Taniguchi S, Ohuchi H, Saito T, Noji S (July 1993). “A chicken homeobox gene related to Drosophila paired is predominantly expressed in the developing limb”. Dev. Biol. 158 (1): 254\u201364. doi:10.1006\/dbio.1993.1184. PMID\u00a08101172.^ a b Lu MF, Cheng HT, Kern MJ, Potter SS, Tran B, Diekwisch TG, Martin JF (February 1999). “prx-1 functions cooperatively with another paired-related homeobox gene, prx-2, to maintain cell fates within the craniofacial mesenchyme” (PDF). Development. 126 (3): 495\u2013504. doi:10.1242\/dev.126.3.495. hdl:1969.1\/184860. PMID\u00a09876178.^ Hu YS, Zhou H, Kartsogiannis V, Eisman JA, Martin TJ, Ng KW (November 1998). “Expression of rat homeobox gene, rHOX, in developing and adult tissues in mice and regulation of its mRNA expression in osteoblasts by bone morphogenetic protein 2 and parathyroid hormone-related protein”. Mol. Endocrinol. 12 (11): 1721\u201332. doi:10.1210\/mend.12.11.0195. PMID\u00a09817598.^ Cserjesi P, Lilly B, Bryson L, Wang Y, Sassoon DA, Olson EN (August 1992). “MHox: a mesodermally restricted homeodomain protein that binds an essential site in the muscle creatine kinase enhancer”. Development. 115 (4): 1087\u2013101. doi:10.1242\/dev.115.4.1087. PMID\u00a01360403.^ ten Berge D, Brouwer A, Korving J, Martin JF, Meijlink F (October 1998). “Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs”. Development. 125 (19): 3831\u201342. doi:10.1242\/dev.125.19.3831. hdl:1969.1\/184321. PMID\u00a09729491.^ Du B, Cawthorn WP, Su A, Doucette CR, Yao Y, Hemati N, Kampert S, McCoin C, Broome DT, Rosen CJ, Yang G, MacDougald OA (February 2013). “The transcription factor paired-related homeobox 1 (Prrx1) inhibits adipogenesis by activating transforming growth factor-\u03b2 (TGF\u03b2) signaling”. J. Biol. Chem. 288 (5): 3036\u201347. doi:10.1074\/jbc.M112.440370. PMC\u00a03561528. PMID\u00a023250756.^ Lu X, Beck GR, Gilbert LC, Camalier CE, Bateman NW, Hood BL, Conrads TP, Kern MJ, You S, Chen H, Nanes MS (January 2011). “Identification of the homeobox protein Prx1 (MHox, Prrx-1) as a regulator of osterix expression and mediator of tumor necrosis factor \u03b1 action in osteoblast differentiation”. J. Bone Miner. Res. 26 (1): 209\u201319. doi:10.1002\/jbmr.203. PMC\u00a03179318. PMID\u00a020683885.Further reading[edit]Grueneberg DA, Simon KJ, Brennan K, Gilman M (1995). “Sequence-specific targeting of nuclear signal transduction pathways by homeodomain proteins”. Mol. Cell. Biol. 15 (6): 3318\u201326. doi:10.1128\/MCB.15.6.3318. PMC\u00a0230565. PMID\u00a07760827.Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Grueneberg DA, Henry RW, Brauer A, Novina CD, Cheriyath V, Roy AL, Gilman M (October 1997). “A multifunctional DNA-binding protein that promotes the formation of serum response factor\/homeodomain complexes: identity to TFII-I”. Genes Dev. 11 (19): 2482\u201393. doi:10.1101\/gad.11.19.2482. PMC\u00a0316568. PMID\u00a09334314.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Nakamura T, Yamazaki Y, Hatano Y, Miura I (1999). “NUP98 is fused to PMX1 homeobox gene in human acute myelogenous leukemia with chromosome translocation t(1;11)(q23;p15)”. Blood. 94 (2): 741\u20137. doi:10.1182\/blood.V94.2.741. PMID\u00a010397741.Kataoka K, Yoshitomo-Nakagawa K, Shioda S, Nishizawa M (2001). “A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities”. J. Biol. Chem. 276 (1): 819\u201326. doi:10.1074\/jbc.M007643200. PMID\u00a011036080.Norris RA, Scott KK, Moore CS, Stetten G, Brown CR, Jabs EW, Wulfsberg EA, Yu J, Kern MJ (November 2000). “Human PRRX1 and PRRX2 genes: cloning, expression, genomic localization, and exclusion as disease genes for Nager syndrome”. Mamm. Genome. 11 (11): 1000\u20135. doi:10.1007\/s003350010193. PMID\u00a011063257. S2CID\u00a09937434.Jones FS, Meech R, Edelman DB, Oakey RJ, Jones PL (July 2001). “Prx1 controls vascular smooth muscle cell proliferation and tenascin-C expression and is upregulated with Prx2 in pulmonary vascular disease”. Circ. Res. 89 (2): 131\u20138. doi:10.1161\/hh1401.093582. PMID\u00a011463719.Izmailova E, Bertley FM, Huang Q, Makori N, Miller CJ, Young RA, Aldovini A (February 2003). “HIV-1 Tat reprograms immature dendritic cells to express chemoattractants for activated T cells and macrophages”. Nat. Med. 9 (2): 191\u20137. doi:10.1038\/nm822. PMID\u00a012539042. S2CID\u00a026145639.Wissm\u00fcller S, Kosian T, Wolf M, Finzsch M, Wegner M (2006). “The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors”. Nucleic Acids Res. 34 (6): 1735\u201344. doi:10.1093\/nar\/gkl105. PMC\u00a01421504. PMID\u00a016582099.Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC,  et\u00a0al. (May 2006). “The DNA sequence and biological annotation of human chromosome 1”. Nature. 441 (7091): 315\u201321. Bibcode:2006Natur.441..315G. doi:10.1038\/nature04727. PMID\u00a016710414.Kim YJ, Ahn JY, Liang P, Ip C, Zhang Y, Park YM (January 2007). “Human prx1 gene is a target of Nrf2 and is up-regulated by hypoxia\/reoxygenation: implication to tumor biology”. Cancer Res. 67 (2): 546\u201354. doi:10.1158\/0008-5472.CAN-06-2401. PMID\u00a017234762.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/prrx1-wikipedia\/#breadcrumbitem","name":"PRRX1 – Wikipedia"}}]}]