[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/qpct-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/qpct-wikipedia\/","headline":"QPCT &#8211; Wikipedia","name":"QPCT &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens QPCT Available structures PDB Ortholog search:","datePublished":"2018-10-08","dateModified":"2018-10-08","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/56\/Protein_QPCT_PDB_2afm.png\/250px-Protein_QPCT_PDB_2afm.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/56\/Protein_QPCT_PDB_2afm.png\/250px-Protein_QPCT_PDB_2afm.png","height":"157","width":"250"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/qpct-wikipedia\/","about":["Wiki"],"wordCount":4177,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensQPCTAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZEE, 2ZEF, 2AFU, 2AFM, 2AFX, 4YU9, 2ZEL, 2ZEG, 2ZEM, 4YWY, 2AFZ, 3PBB, 2ZEH, 2AFS, 3SI0, 2ZEP, 3PBE, 2ZEO, 2ZED, 2AFO, 2ZEN, 2AFW       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4IdentifiersAliasesQPCT, GCT, QC, sQC, glutaminyl-peptide cyclotransferaseExternal IDsOMIM: 607065 MGI: 1917786 HomoloGene: 8238 GeneCards: QPCT WikidataGlutaminyl-peptide cyclotransferase is an enzyme that in humans is encoded by the QPCT gene.[5][6]This gene encodes human pituitary glutaminyl cyclase, which is responsible for the presence of pyroglutamyl residues in many neuroendocrine peptides. The amino acid sequence of this enzyme is 86% identical to that of bovine glutaminyl cyclase.[6]References[edit]Further reading[edit]Busby WH, Quackenbush GE, Humm J,  et\u00a0al. (1987). &#8220;An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes&#8221;. J. Biol. Chem. 262 (18): 8532\u20136. doi:10.1016\/S0021-9258(18)47446-7. PMID\u00a03597387.Bateman RC, Temple JS, Misquitta SA, Booth RE (2001). &#8220;Evidence for essential histidines in human pituitary glutaminyl cyclase&#8221;. Biochemistry. 40 (37): 11246\u201350. doi:10.1021\/bi011177o. PMID\u00a011551224.Schilling S, Hoffmann T, Rosche F,  et\u00a0al. (2002). &#8220;Heterologous expression and characterization of human glutaminyl cyclase: evidence for a disulfide bond with importance for catalytic activity&#8221;. Biochemistry. 41 (35): 10849\u201357. doi:10.1021\/bi0260381. PMID\u00a012196024.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). &#8220;Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences&#8221;. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS&#8230;9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Schilling S, Niestroj AJ, Rahfeld JU,  et\u00a0al. (2004). &#8220;Identification of human glutaminyl cyclase as a metalloenzyme. Potent inhibition by imidazole derivatives and heterocyclic chelators&#8221;. J. Biol. Chem. 278 (50): 49773\u20139. doi:10.1074\/jbc.M309077200. PMID\u00a014522962.Booth RE, Misquitta SA, Bateman RC (2004). &#8220;Human pituitary glutaminyl cyclase: expression in insect cells and dye affinity purification&#8221;. Protein Expr. Purif. 32 (1): 141\u20136. doi:10.1016\/S1046-5928(03)00226-2. PMID\u00a014680951.Ezura Y, Kajita M, Ishida R,  et\u00a0al. (2005). &#8220;Association of multiple nucleotide variations in the pituitary glutaminyl cyclase gene (QPCT) with low radial BMD in adult women&#8221;. J. Bone Miner. Res. 19 (8): 1296\u2013301. doi:10.1359\/JBMR.040324. PMID\u00a015231017. S2CID\u00a08470506.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). &#8220;The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)&#8221;. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Huang KF, Liu YL, Cheng WJ,  et\u00a0al. (2005). &#8220;Crystal structures of human glutaminyl cyclase, an enzyme responsible for protein N-terminal pyroglutamate formation&#8221;. Proc. Natl. Acad. Sci. U.S.A. 102 (37): 13117\u201322. Bibcode:2005PNAS..10213117H. doi:10.1073\/pnas.0504184102. PMC\u00a01201592. PMID\u00a016135565.Huang QY, Kung AW (2007). &#8220;The association of common polymorphisms in the QPCT gene with bone mineral density in the Chinese population&#8221;. Journal of Human Genetics. 52 (9): 757\u201362. doi:10.1007\/s10038-007-0178-6. PMID\u00a017687619.PDB gallery2afm: Crystal structure of human glutaminyl cyclase at pH 6.5       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x42afo: Crystal structure of human glutaminyl cyclase at pH 8.02afs: Crystal structure of the genetic mutant R54W of human glutaminyl cyclase2afu: Crystal structure of human glutaminyl cyclase in complex with glutamine t-butyl ester2afw: Crystal structure of human glutaminyl cyclase in complex with N-acetylhistamine2afx: Crystal structure of human glutaminyl cyclase in complex with 1-benzylimidazole2afz: Crystal structure of human glutaminyl cyclase in complex with 1-vinylimidazole       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/qpct-wikipedia\/#breadcrumbitem","name":"QPCT &#8211; Wikipedia"}}]}]