[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rbm3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/rbm3-wikipedia\/","headline":"RBM3 – Wikipedia","name":"RBM3 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Putative RNA-binding protein 3 is a","datePublished":"2016-06-09","dateModified":"2016-06-09","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/rbm3-wikipedia\/","about":["Wiki"],"wordCount":3512,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensPutative RNA-binding protein 3 is a protein that in humans is encoded by the RBM3 gene.[4][5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Clinical significance[edit]References[edit]Further reading[edit]Function[edit]This gene is a member of the glycine-rich RNA-binding protein family and encodes a protein with one RNA recognition motif (RRM) domain. Expression of this gene is induced by cold shock and low oxygen tension. A pseudogene exists on chromosome 1. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[5]RBM3 is cold-induced RNA binding protein and is involved in mRNA biogenesis exerts anti-apoptotic effects.[6] According to antibody-based profiling and transcriptomics analysis, RBM3 protein is present in all analysed human tissues[7] and based on confocal microscopy mainly localised to the nucleoplasm.[8]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Clinical significance[edit]RBM3 is a proto-oncogene that is associated with tumor progression and metastasis and is a potential cancer biomarker.[6] Based on patient survival data, high levels of RBM3 protein in tumor cells is a favourable prognostic biomarker in colorectal cancer.[9]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000102317 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Derry JM, Kerns JA, Francke U (December 1995). “RBM3, a novel human gene in Xp11.23 with a putative RNA-binding domain”. Human Molecular Genetics. 4 (12): 2307\u201311. doi:10.1093\/hmg\/4.12.2307. PMID\u00a08634703.^ a b “Entrez Gene: RBM3 RNA binding motif (RNP1, RRM) protein 3”.^ a b Zhou RB, Lu XL, Zhang CY, Yin DC (March 2017). “RNA binding motif protein 3: a potential biomarker in cancer and therapeutic target in neuroprotection”. Oncotarget. 8 (13): 22235\u201322250. doi:10.18632\/oncotarget.14755. PMC\u00a05400660. PMID\u00a028118608.^ “Tissue expression of RBM3 – Summary”. The Human Protein Atlas.^ “Cell atlas – RBM3”. The Human Protein Atlas.^ “Expression of RBM3 in cancer – Summary”. The Human Protein Atlas.Further reading[edit]Danno S, Nishiyama H, Higashitsuji H, Yokoi H, Xue JH, Itoh K, Matsuda T, Fujita J (July 1997). “Increased transcript level of RBM3, a member of the glycine-rich RNA-binding protein family, in human cells in response to cold stress”. Biochemical and Biophysical Research Communications. 236 (3): 804\u20137. doi:10.1006\/bbrc.1997.7059. PMID\u00a09245737.Chappell SA, Mauro VP (September 2003). “The internal ribosome entry site (IRES) contained within the RNA-binding motif protein 3 (Rbm3) mRNA is composed of functionally distinct elements”. The Journal of Biological Chemistry. 278 (36): 33793\u2013800. doi:10.1074\/jbc.M303495200. PMID\u00a012824175.Wellmann S, B\u00fchrer C, Moderegger E, Zelmer A, Kirschner R, Koehne P, Fujita J, Seeger K (April 2004). “Oxygen-regulated expression of the RNA-binding proteins RBM3 and CIRP by a HIF-1-independent mechanism”. Journal of Cell Science. 117 (Pt 9): 1785\u201394. doi:10.1242\/jcs.01026. PMID\u00a015075239.Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (May 2004). “Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry”. Analytical Chemistry. 76 (10): 2763\u201372. doi:10.1021\/ac035352d. PMID\u00a015144186.Dellis S, Strickland KC, McCrary WJ, Patel A, Stocum E, Wright CF (November 2004). “Protein interactions among the vaccinia virus late transcription factors”. Virology. 329 (2): 328\u201336. doi:10.1016\/j.virol.2004.08.017. hdl:10161\/15063. PMID\u00a015518812.Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (January 2005). “Nucleolar proteome dynamics”. Nature. 433 (7021): 77\u201383. Bibcode:2005Natur.433…77A. doi:10.1038\/nature03207. PMID\u00a015635413. S2CID\u00a04344740.Ong SE, Mittler G, Mann M (November 2004). “Identifying and quantifying in vivo methylation sites by heavy methyl SILAC”. Nature Methods. 1 (2): 119\u201326. doi:10.1038\/nmeth715. PMID\u00a015782174. S2CID\u00a06654604.Mart\u00ednez-Arribas F, Agudo D, Poll\u00e1n M, G\u00f3mez-Esquer F, D\u00edaz-Gil G, Lucas R, Schneider J (April 2006). “Positive correlation between the expression of X-chromosome RBM genes (RBMX, RBM3, RBM10) and the proapoptotic Bax gene in human breast cancer”. Journal of Cellular Biochemistry. 97 (6): 1275\u201382. doi:10.1002\/jcb.20725. PMID\u00a016552754. S2CID\u00a09804734.     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rbm3-wikipedia\/#breadcrumbitem","name":"RBM3 – Wikipedia"}}]}]