[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rbm39-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/rbm39-wikipedia\/","headline":"RBM39 – Wikipedia","name":"RBM39 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens RNA-binding protein 39 is a protein that in","datePublished":"2019-08-10","dateModified":"2019-08-10","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/cc\/PDB_2cq4_EBI.jpg\/180px-PDB_2cq4_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/cc\/PDB_2cq4_EBI.jpg\/180px-PDB_2cq4_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/rbm39-wikipedia\/","about":["Wiki"],"wordCount":3037,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensRNA-binding protein 39 is a protein that in humans is encoded by the RBM39 gene.[5][6]Table of ContentsFunction[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]The protein encoded by this gene is an RNA binding protein and possible splicing factor. The encoded protein is found in the nucleus, where it colocalizes with core spliceosomal proteins. Studies of a mouse protein with high sequence similarity to this protein suggest that this protein may act as a transcriptional coactivator for JUN\/AP-1 and estrogen receptors. Multiple transcript variants encoding different isoforms have been observed for this gene.[6]Interactions[edit]RBM39 has been shown to interact with Estrogen receptor alpha,[7]Estrogen receptor beta[7] and C-jun.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000131051 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027620 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Imai H, Chan EK, Kiyosawa K, Fu XD, Tan EM (Dec 1993). “Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma”. J Clin Invest. 92 (5): 2419\u201326. doi:10.1172\/JCI116848. PMC\u00a0288425. PMID\u00a08227358.^ a b “Entrez Gene: RBM39 RNA binding motif protein 39”.^ a b c Jung DJ, Na SY, Na DS, Lee JW (Jan 2002). “Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors”. J. Biol. Chem. 277 (2): 1229\u201334. doi:10.1074\/jbc.M110417200. PMID\u00a011704680.Further reading[edit]Jung DJ, Na SY, Na DS, Lee JW (2002). “Molecular cloning and characterization of CAPER, a novel coactivator of activating protein-1 and estrogen receptors”. J. Biol. Chem. 277 (2): 1229\u201334. doi:10.1074\/jbc.M110417200. PMID\u00a011704680.Lehner B, Semple JI, Brown SE, Counsell D, Campbell RD, Sanderson CM (2004). “Analysis of a high-throughput yeast two-hybrid system and its use to predict the function of intracellular proteins encoded within the human MHC class III region”. Genomics. 83 (1): 153\u201367. doi:10.1016\/S0888-7543(03)00235-0. PMID\u00a014667819.Andersen JS, Lam YW, Leung AK, Ong SE, Lyon CE, Lamond AI, Mann M (2005). “Nucleolar proteome dynamics”. Nature. 433 (7021): 77\u201383. Bibcode:2005Natur.433…77A. doi:10.1038\/nature03207. PMID\u00a015635413. S2CID\u00a04344740.Dowhan DH, Hong EP, Auboeuf D, Dennis AP, Wilson MM, Berget SM, O’Malley BW (2005). “Steroid hormone receptor coactivation and alternative RNA splicing by U2AF65-related proteins CAPERalpha and CAPERbeta”. Mol. Cell. 17 (3): 429\u201339. doi:10.1016\/j.molcel.2004.12.025. PMID\u00a015694343.Sun NN, Fastje CD, Wong SS, Sheppard PR, Macdonald SJ, Ridenour G, Hyde JD, Witten ML (2005). “Dose-dependent transcriptome changes by metal ores on a human acute lymphoblastic leukemia cell line”. Toxicology and Industrial Health. 19 (7\u201310): 157\u201363. doi:10.1191\/0748233703th185oa. PMID\u00a015747776. S2CID\u00a014394243.Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983. S2CID\u00a07827573.PDB gallery2cq4: solution structure of RNA binding domain in RNA binding motif protein 23  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rbm39-wikipedia\/#breadcrumbitem","name":"RBM39 – Wikipedia"}}]}]