[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rfwd2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/rfwd2-wikipedia\/","headline":"RFWD2 – Wikipedia","name":"RFWD2 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens E3 ubiquitin-protein ligase RFWD2 is an","datePublished":"2016-12-28","dateModified":"2016-12-28","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/rfwd2-wikipedia\/","about":["Wiki"],"wordCount":3397,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensE3 ubiquitin-protein ligase RFWD2 is an enzyme that in humans is encoded by the RFWD2 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Interactions[edit]RFWD2 has been shown to interact with C-jun.[7][8]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000143207 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000040782 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Wang H, Kang D, Deng XW, Wei N (Sep 1999). “Evidence for functional conservation of a mammalian homologue of the light-responsive plant protein COP1”. Curr Biol. 9 (13): 711\u20134. doi:10.1016\/S0960-9822(99)80314-5. PMID\u00a010395541. S2CID\u00a02822539.^ “Entrez Gene: RFWD2 ring finger and WD repeat domain 2”.^ Wertz IE, O’Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM (Feb 2004). “Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase” (PDF). Science. 303 (5662): 1371\u20134. Bibcode:2004Sci…303.1371W. doi:10.1126\/science.1093549. PMID\u00a014739464. S2CID\u00a040501515.^ Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, Putignano S, Rogge L, Pardi R (May 2003). “Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity”. J. Biol. Chem. 278 (22): 19682\u201390. doi:10.1074\/jbc.M212681200. PMID\u00a012615916.Further reading[edit]Hoecker U, Quail PH (2001). “The phytochrome A-specific signaling intermediate SPA1 interacts directly with COP1, a constitutive repressor of light signaling in Arabidopsis”. J. Biol. Chem. 276 (41): 38173\u20138. doi:10.1074\/jbc.M103140200. PMID\u00a011461903.Yi C, Wang H, Wei N, Deng XW (2003). “An initial biochemical and cell biological characterization of the mammalian homologue of a central plant developmental switch, COP1”. BMC Cell Biol. 3: 30. doi:10.1186\/1471-2121-3-30. PMC\u00a0138799. PMID\u00a012466024.Bianchi E, Denti S, Catena R, Rossetti G, Polo S, Gasparian S, Putignano S, Rogge L, Pardi R (2003). “Characterization of human constitutive photomorphogenesis protein 1, a RING finger ubiquitin ligase that interacts with Jun transcription factors and modulates their transcriptional activity”. J. Biol. Chem. 278 (22): 19682\u201390. doi:10.1074\/jbc.M212681200. PMID\u00a012615916.Wertz IE, O’Rourke KM, Zhang Z, Dornan D, Arnott D, Deshaies RJ, Dixit VM (2004). “Human De-etiolated-1 regulates c-Jun by assembling a CUL4A ubiquitin ligase” (PDF). Science. 303 (5662): 1371\u20134. Bibcode:2004Sci…303.1371W. doi:10.1126\/science.1093549. PMID\u00a014739464. S2CID\u00a040501515.Dornan D, Wertz I, Shimizu H, Arnott D, Frantz GD, Dowd P, O’Rourke K, Koeppen H, Dixit VM (2004). “The ubiquitin ligase COP1 is a critical negative regulator of p53”. Nature. 429 (6987): 86\u201392. Bibcode:2004Natur.429…86D. doi:10.1038\/nature02514. PMID\u00a015103385. S2CID\u00a04319187.Dornan D, Bheddah S, Newton K, Ince W, Frantz GD, Dowd P, Koeppen H, Dixit VM, French DM (2004). “COP1, the negative regulator of p53, is overexpressed in breast and ovarian adenocarcinomas”. Cancer Res. 64 (20): 7226\u201330. doi:10.1158\/0008-5472.CAN-04-2601. PMID\u00a015492238.Dornan D, Shimizu H, Mah A, Dudhela T, Eby M, O’rourke K, Seshagiri S, Dixit VM (2006). “ATM engages autodegradation of the E3 ubiquitin ligase COP1 after DNA damage”. Science. 313 (5790): 1122\u20136. Bibcode:2006Sci…313.1122D. doi:10.1126\/science.1127335. PMID\u00a016931761. S2CID\u00a034368821.       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