[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rhob-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/rhob-wikipedia\/","headline":"RHOB – Wikipedia","name":"RHOB – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Ras homolog gene family, member B,","datePublished":"2022-04-07","dateModified":"2022-04-07","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/52\/PDB_2fv8_EBI.jpg\/180px-PDB_2fv8_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/52\/PDB_2fv8_EBI.jpg\/180px-PDB_2fv8_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/rhob-wikipedia\/","about":["Wiki"],"wordCount":7005,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensRas homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4RHOB is a member of the Rho GTP-binding protein family.[7]Table of ContentsInteractions[edit]See also[edit]References[edit]Further reading[edit]Interactions[edit]RHOB has been shown to interact with CIT,[8]ARHGEF3,[9]ARHGDIG[10] and RHPN2.[11]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000143878 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000054364 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: RHOB ras homolog gene family, member B”.^ Chardin P, Madaule P, Tavitian A (March 1988). “Coding sequence of human rho cDNAs clone 6 and clone 9”. Nucleic Acids Research. 16 (6): 2717. doi:10.1093\/nar\/16.6.2717. PMC\u00a0336400. PMID\u00a03283705.^ Wennerberg K, Der CJ (March 2004). “Rho-family GTPases: it’s not only Rac and Rho (and I like it)”. Journal of Cell Science. 117 (Pt 8): 1301\u201312. doi:10.1242\/jcs.01118. PMID\u00a015020670.^ Madaule P, Furuyashiki T, Reid T, Ishizaki T, Watanabe G, Morii N, Narumiya S (December 1995). “A novel partner for the GTP-bound forms of rho and rac”. FEBS Letters. 377 (2): 243\u20138. doi:10.1016\/0014-5793(95)01351-2. PMID\u00a08543060.^ Arthur WT, Ellerbroek SM, Der CJ, Burridge K, Wennerberg K (November 2002). “XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC”. The Journal of Biological Chemistry. 277 (45): 42964\u201372. doi:10.1074\/jbc.M207401200. PMID\u00a012221096.^ Zalcman G, Closson V, Camonis J, Honor\u00e9 N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996). “RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG”. The Journal of Biological Chemistry. 271 (48): 30366\u201374. doi:10.1074\/jbc.271.48.30366. PMID\u00a08939998.^ Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C, Pirson I (December 2002). “Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP” (PDF). European Journal of Biochemistry. 269 (24): 6241\u20139. doi:10.1046\/j.1432-1033.2002.03343.x. PMID\u00a012473120. S2CID\u00a023901713.Further reading[edit]Bravo-Nuevo A, Sugimoto H, Iyer S, Fallon Z, Lucas JM, Kazerounian S, Prendergast GC, Kalluri R, Shapiro NI, Benjamin LE (January 2011). “RhoB loss prevents streptozotocin-induced diabetes and ameliorates diabetic complications in mice”. The American Journal of Pathology. 178 (1): 245\u201352. doi:10.1016\/j.ajpath.2010.11.040. PMC\u00a03069827. PMID\u00a021224061.Casey PJ, Seabra MC (March 1996). “Protein prenyltransferases”. The Journal of Biological Chemistry. 271 (10): 5289\u201392. doi:10.1074\/jbc.271.10.5289. PMID\u00a08621375.Adamson P, Marshall CJ, Hall A, Tilbrook PA (October 1992). “Post-translational modifications of p21rho proteins”. The Journal of Biological Chemistry. 267 (28): 20033\u20138. doi:10.1016\/S0021-9258(19)88661-1. PMID\u00a01400319.Cannizzaro LA, Madaule P, Hecht F, Axel R, Croce CM, Huebner K (February 1990). “Chromosome localization of human ARH genes, a ras-related gene family”. Genomics. 6 (2): 197\u2013203. doi:10.1016\/0888-7543(90)90557-B. PMID\u00a02407642.Chardin P, Madaule P, Tavitian A (March 1988). “Coding sequence of human rho cDNAs clone 6 and clone 9”. Nucleic Acids Research. 16 (6): 2717. doi:10.1093\/nar\/16.6.2717. PMC\u00a0336400. PMID\u00a03283705.Madaule P, Axel R (May 1985). “A novel ras-related gene family”. Cell. 41 (1): 31\u201340. doi:10.1016\/0092-8674(85)90058-3. PMID\u00a03888408. S2CID\u00a032708060.Robertson D, Paterson HF, Adamson P, Hall A, Monaghan P (May 1995). “Ultrastructural localization of ras-related proteins using epitope-tagged plasmids”. The Journal of Histochemistry and Cytochemistry. 43 (5): 471\u201380. doi:10.1177\/43.5.7537292. PMID\u00a07537292.Armstrong SA, Hannah VC, Goldstein JL, Brown MS (April 1995). “CAAX geranylgeranyl transferase transfers farnesyl as efficiently as geranylgeranyl to RhoB”. The Journal of Biological Chemistry. 270 (14): 7864\u20138. doi:10.1074\/jbc.270.14.7864. PMID\u00a07713879.Bonaldo MF, Lennon G, Soares MB (September 1996). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Research. 6 (9): 791\u2013806. doi:10.1101\/gr.6.9.791. PMID\u00a08889548.Zalcman G, Closson V, Camonis J, Honor\u00e9 N, Rousseau-Merck MF, Tavitian A, Olofsson B (November 1996). “RhoGDI-3 is a new GDP dissociation inhibitor (GDI). Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG”. The Journal of Biological Chemistry. 271 (48): 30366\u201374. doi:10.1074\/jbc.271.48.30366. PMID\u00a08939998.Mellor H, Flynn P, Nobes CD, Hall A, Parker PJ (February 1998). “PRK1 is targeted to endosomes by the small GTPase, RhoB”. The Journal of Biological Chemistry. 273 (9): 4811\u20134. doi:10.1074\/jbc.273.9.4811. PMID\u00a09478917.Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (June 1998). “Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro”. DNA Research. 5 (3): 169\u201376. doi:10.1093\/dnares\/5.3.169. PMID\u00a09734811.Liu JP, Jessell TM (December 1998). “A role for rhoB in the delamination of neural crest cells from the dorsal neural tube”. Development. 125 (24): 5055\u201367. doi:10.1242\/dev.125.24.5055. PMID\u00a09811589.Gampel A, Parker PJ, Mellor H (September 1999). “Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB”. Current Biology. 9 (17): 955\u20138. doi:10.1016\/S0960-9822(99)80422-9. PMID\u00a010508588. S2CID\u00a09616910.Matarrese P, Conti L, Varano B, Gauzzi MC, Belardelli F, Gessani S, Malorni W (January 2000). “The HIV-1 vpr protein induces anoikis-resistance by modulating cell adhesion process and microfilament system assembly”. Cell Death and Differentiation. 7 (1): 25\u201336. doi:10.1038\/sj.cdd.4400616. PMID\u00a010713718.Liu Ax, Du W, Liu JP, Jessell TM, Prendergast GC (August 2000). “RhoB alteration is necessary for apoptotic and antineoplastic responses to farnesyltransferase inhibitors”. Molecular and Cellular Biology. 20 (16): 6105\u201313. doi:10.1128\/MCB.20.16.6105-6113.2000. PMC\u00a086086. PMID\u00a010913192.Michaelson D, Silletti J, Murphy G, D’Eustachio P, Rush M, Philips MR (January 2001). “Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding”. The Journal of Cell Biology. 152 (1): 111\u201326. doi:10.1083\/jcb.152.1.111. PMC\u00a02193662. PMID\u00a011149925.Cerniglia GJ, Bernhard EJ, Prendergast GC (May 2001). “RhoB is required to mediate apoptosis in neoplastically transformed cells after DNA damage”. Proceedings of the National Academy of Sciences of the United States of America. 98 (11): 6192\u20137. Bibcode:2001PNAS…98.6192L. doi:10.1073\/pnas.111137198. PMC\u00a033444. PMID\u00a011353846.Diviani D, Soderling J, Scott JD (November 2001). “AKAP-Lbc anchors protein kinase A and nucleates Galpha 12-selective Rho-mediated stress fiber formation”. The Journal of Biological Chemistry. 276 (47): 44247\u201357. doi:10.1074\/jbc.M106629200. PMID\u00a011546812.Adnane J, Seijo E, Chen Z, Bizouarn F, Leal M, Sebti SM, Mu\u00f1oz-Antonia T (March 2002). “RhoB, not RhoA, represses the transcription of the transforming growth factor beta type II receptor by a mechanism involving activator protein 1”. The Journal of Biological Chemistry. 277 (10): 8500\u20137. doi:10.1074\/jbc.M104367200. PMID\u00a011741970.PDB gallery2fv8: The crystal structure of RhoB in the GDP-bound state       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rhob-wikipedia\/#breadcrumbitem","name":"RHOB – Wikipedia"}}]}]