[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rin1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/rin1-wikipedia\/","headline":"RIN1 – Wikipedia","name":"RIN1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Ras and Rab interactor 1 is","datePublished":"2021-06-14","dateModified":"2021-06-14","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/rin1-wikipedia\/","wordCount":5968,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensRas and Rab interactor 1 is a protein that in humans is encoded by the RIN1 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Interactions[edit]RIN1 has been shown to interact with HRAS.[8][9]Additionally, RIN1 binds and activates ABL family tyrosine kinases.References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000174791 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024883 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Han L, Wong D, Dhaka A, Afar D, White M, Xie W, Herschman H, Witte O, Colicelli J (Jun 1997). “Protein binding and signaling properties of RIN1 suggest a unique effector function”. Proc Natl Acad Sci U S A. 94 (10): 4954\u20139. Bibcode:1997PNAS…94.4954H. doi:10.1073\/pnas.94.10.4954. PMC\u00a024612. PMID\u00a09144171.^ Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M (May 1991). “Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae”. Proc Natl Acad Sci U S A. 88 (7): 2913\u20137. Bibcode:1991PNAS…88.2913C. doi:10.1073\/pnas.88.7.2913. PMC\u00a051350. PMID\u00a01849280.^ “Entrez Gene: RIN1 Ras and Rab interactor 1”.^ Mitin, Natalia Y; Ramocki Melissa B; Zullo Alfred J; Der Channing J; Konieczny Stephen F; Taparowsky Elizabeth J (May 2004). “Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization”. J. Biol. Chem. United States. 279 (21): 22353\u201361. doi:10.1074\/jbc.M312867200. ISSN\u00a00021-9258. PMID\u00a015031288.^ Han, L; Colicelli J (Mar 1995). “A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1”. Mol. Cell. Biol. UNITED STATES. 15 (3): 1318\u201323. doi:10.1128\/mcb.15.3.1318. ISSN\u00a00270-7306. PMC\u00a0230355. PMID\u00a07862125.Further reading[edit]Dkaha A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O’Dell TJ, Colicelli J (2003). “The RAS effector RIN1 modulates the formation of aversive memories”. J. Neurosci. 23 (3): 748\u2013757. doi:10.1523\/JNEUROSCI.23-03-00748.2003. PMC\u00a06741936. PMID\u00a012574403.Trowbridge IS, Lesley J, Trotter J, Hyman R (1985). “Thymocyte subpopulation enriched for progenitors with an unrearranged T-cell receptor beta-chain gene”. Nature. 315 (6021): 666\u20139. Bibcode:1985Natur.315..666T. doi:10.1038\/315666a0. PMID\u00a03874369. S2CID\u00a020469621.Han L, Colicelli J (1995). “A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1”. Mol. Cell. Biol. 15 (3): 1318\u201323. doi:10.1128\/mcb.15.3.1318. PMC\u00a0230355. PMID\u00a07862125.Afar DE, Han L, McLaughlin J,  et\u00a0al. (1997). “Regulation of the oncogenic activity of BCR-ABL by a tightly bound substrate protein RIN1”. Immunity. 6 (6): 773\u201382. doi:10.1016\/S1074-7613(00)80452-5. PMID\u00a09208849.Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF (2001). “Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1”. Dev. Cell. 1 (1): 73\u201382. doi:10.1016\/S1534-5807(01)00008-9. PMID\u00a011703925.Wang Y, Waldron RT, Dhaka A,  et\u00a0al. (2002). “The RAS Effector RIN1 Directly Competes with RAF and Is Regulated by 14-3-3 Proteins”. Mol. Cell. Biol. 22 (3): 916\u201326. doi:10.1128\/MCB.22.3.916-926.2001. PMC\u00a0133556. PMID\u00a011784866.Murphy GA, Graham SM, Morita S,  et\u00a0al. (2002). “Involvement of phosphatidylinositol 3-kinase, but not RalGDS, in TC21\/R-Ras2-mediated transformation”. J. Biol. Chem. 277 (12): 9966\u201375. doi:10.1074\/jbc.M109059200. PMID\u00a011788587.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Mitin NY, Ramocki MB, Zullo AJ,  et\u00a0al. (2004). “Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization”. J. Biol. Chem. 279 (21): 22353\u201361. doi:10.1074\/jbc.M312867200. PMID\u00a015031288.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Hu H, Bliss JM, Wang Y, Colicelli J (2005). “RIN1 is an ABL tyrosine kinase activator and a regulator of epithelial-cell adhesion and migration”. Curr. Biol. 15 (9): 815\u201323. doi:10.1016\/j.cub.2005.03.049. PMID\u00a015886098. S2CID\u00a06736561.Zhang Y, Wolf-Yadlin A, Ross PL,  et\u00a0al. (2005). “Time-resolved mass spectrometry of tyrosine phosphorylation sites in the epidermal growth factor receptor signaling network reveals dynamic modules”. Mol. Cell. Proteomics. 4 (9): 1240\u201350. doi:10.1074\/mcp.M500089-MCP200. PMID\u00a015951569.Rual JF, Venkatesan K, Hao T,  et\u00a0al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.Hunker CM, Giambini H, Galvis A,  et\u00a0al. (2006). “Rin1 regulates insulin receptor signal transduction pathways”. Exp. Cell Res. 312 (7): 1106\u201318. doi:10.1016\/j.yexcr.2005.12.021. PMID\u00a016457816.Beausoleil SA, Vill\u00e9n J, Gerber SA,  et\u00a0al. (2006). “A probability-based approach for high-throughput protein phosphorylation analysis and site localization”. Nat. Biotechnol. 24 (10): 1285\u201392. doi:10.1038\/nbt1240. PMID\u00a016964243. S2CID\u00a014294292.Senda K, Goi T, Hirono Y,  et\u00a0al. (2007). “Analysis of RIN1 gene expression in colorectal cancer”. Oncol. Rep. 17 (5): 1171\u20135. doi:10.3892\/or.17.5.1171. PMID\u00a017390061.Kong C, Su X, Chen PI, Stahl PD (2007). “Rin1 interacts with signal-transducing adaptor molecule (STAM) and mediates epidermal growth factor receptor trafficking and degradation”. J. Biol. Chem. 282 (20): 15294\u2013301. doi:10.1074\/jbc.M611538200. PMID\u00a017403676.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rin1-wikipedia\/#breadcrumbitem","name":"RIN1 – Wikipedia"}}]}]