[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rit1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/rit1-wikipedia\/","headline":"RIT1 &#8211; Wikipedia","name":"RIT1 &#8211; Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens GTP-binding protein Rit1 is a protein","datePublished":"2019-05-05","dateModified":"2019-05-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/rit1-wikipedia\/","about":["Wiki"],"wordCount":3722,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensGTP-binding protein Rit1 is a protein that in humans is encoded by the RIT1 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Clinical significance[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]RIT belongs to the RAS (HRAS; MIM 190020) subfamily of small GTPases (Hynds et al., 2003).[supplied by OMIM][7]Clinical significance[edit]Mutations in RIT1 are associated to Noonan syndrome.[8]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Interactions[edit]RIT1 has been shown to interact with KLHL12[9] and Merlin.[10]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000143622 &#8211; Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000028057 &#8211; Ensembl, May 2017^ &#8220;Human PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ &#8220;Mouse PubMed Reference:&#8221;. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Lee CH, Della NG, Chew CE, Zack DJ (November 1996). &#8220;Rin, a neuron-specific and calmodulin-binding small G-protein, and Rit define a novel subfamily of ras proteins&#8221;. The Journal of Neuroscience. 16 (21): 6784\u201394. doi:10.1523\/JNEUROSCI.16-21-06784.1996. PMC\u00a06579259. PMID\u00a08824319.^ Wes PD, Yu M, Montell C (November 1996). &#8220;RIC, a calmodulin-binding Ras-like GTPase&#8221;. The EMBO Journal. 15 (21): 5839\u201348. doi:10.1002\/j.1460-2075.1996.tb00971.x. PMC\u00a0452332. PMID\u00a08918462.^ a b &#8220;Entrez Gene: RIT1 Ras-like without CAAX 1&#8221;.^ Gos M, Fahiminiya S, Pozna\u0144ski J, Klapecki J, Obersztyn E, Piotrowicz M, Wierzba J, Posmyk R, Bal J, Majewski J (September 2014). &#8220;Contribution of RIT1 mutations to the pathogenesis of Noonan syndrome: four new cases and further evidence of heterogeneity&#8221;. American Journal of Medical Genetics. Part A. 164A (9): 2310\u20136. doi:10.1002\/ajmg.a.36646. PMID\u00a024939608. S2CID\u00a02005508.^ Rondou P, Haegeman G, Vanhoenacker P, Van Craenenbroeck K (April 2008). &#8220;BTB Protein KLHL12 targets the dopamine D4 receptor for ubiquitination by a Cul3-based E3 ligase&#8221;. The Journal of Biological Chemistry. 283 (17): 11083\u201396. doi:10.1074\/jbc.M708473200. PMC\u00a02431063. PMID\u00a018303015.^ Huang J, Chen J (July 2008). &#8220;VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation&#8221;. Oncogene. 27 (29): 4056\u201364. doi:10.1038\/onc.2008.44. PMID\u00a018332868.Further reading[edit]Shao H, Kadono-Okuda K, Finlin BS, Andres DA (November 1999). &#8220;Biochemical characterization of the Ras-related GTPases Rit and Rin&#8221;. Archives of Biochemistry and Biophysics. 371 (2): 207\u201319. doi:10.1006\/abbi.1999.1448. PMID\u00a010545207.Shao H, Andres DA (September 2000). &#8220;A novel RalGEF-like protein, RGL3, as a candidate effector for rit and Ras&#8221;. The Journal of Biological Chemistry. 275 (35): 26914\u201324. doi:10.1074\/jbc.M002241200. PMID\u00a010869344.Hynds DL, Spencer ML, Andres DA, Snow DM (May 2003). &#8220;Rit promotes MEK-independent neurite branching in human neuroblastoma cells&#8221;. Journal of Cell Science. 116 (Pt 10): 1925\u201335. doi:10.1242\/jcs.00401. PMID\u00a012668729.Li JT, Liu W, Kuang ZH, Zhang RH, Chen HK, Feng QS (February 2004). &#8220;[Mutation and amplification of RIT1 gene in hepatocellular carcinoma]&#8221;. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics. 21 (1): 43\u20136. PMID\u00a014767908.Shi GX, Andres DA (January 2005). &#8220;Rit contributes to nerve growth factor-induced neuronal differentiation via activation of B-Raf-extracellular signal-regulated kinase and p38 mitogen-activated protein kinase cascades&#8221;. Molecular and Cellular Biology. 25 (2): 830\u201346. doi:10.1128\/MCB.25.2.830-846.2005. PMC\u00a0543422. PMID\u00a015632082.Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, Shinjo F, Liu Y, Dembowy J, Taylor IW, Luga V, Przulj N, Robinson M, Suzuki H, Hayashizaki Y, Jurisica I, Wrana JL (March 2005). &#8220;High-throughput mapping of a dynamic signaling network in mammalian cells&#8221;. Science. 307 (5715): 1621\u20135. Bibcode:2005Sci&#8230;307.1621B. doi:10.1126\/science.1105776. PMID\u00a015761153. S2CID\u00a039457788.Benmaamar R, Pagano M (September 2005). &#8220;Involvement of the SCF complex in the control of Cdh1 degradation in S-phase&#8221;. Cell Cycle. 4 (9): 1230\u20132. doi:10.4161\/cc.4.9.2048. PMID\u00a016123585.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rit1-wikipedia\/#breadcrumbitem","name":"RIT1 &#8211; Wikipedia"}}]}]