[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rnf14-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/rnf14-wikipedia\/","headline":"RNF14 – Wikipedia","name":"RNF14 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens E3 ubiquitin-protein ligase RNF14 is an enzyme that","datePublished":"2019-11-19","dateModified":"2019-11-19","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/rnf14-wikipedia\/","about":["Wiki"],"wordCount":5382,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensE3 ubiquitin-protein ligase RNF14 is an enzyme that in humans is encoded by the RNF14 gene.[5][6][7]Table of ContentsFunction[edit]Interactions[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein interacts with androgen receptor (AR) and may function as a coactivator that induces AR target gene expression in prostate. A dominant negative mutant of this gene has been demonstrated to inhibit the AR-mediated growth of prostate cancer. This protein also interacts with class III ubiquitin-conjugating enzymes (E2s) and may act as a ubiquitin-ligase (E3) in the ubiquitination of certain nuclear proteins. Five alternatively spliced transcript variants encoding two distinct isoforms have been reported.[7] Another function of RNF14 protein relates to its regulation of the inter-relationship between bioenergetic status and inflammation. It influences the expression of mitochondrial and immune-related genes in skeletal muscle including cytokines and interferon regulatory factors.[8]Interactions[edit]RNF14 has been shown to interact with the Androgen receptor.[5][9][10][11]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000013561 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060450 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b Kang HY, Yeh S, Fujimoto N, Chang C (Apr 1999). “Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor”. J Biol Chem. 274 (13): 8570\u20136. doi:10.1074\/jbc.274.13.8570. PMID\u00a010085091.^ Ueki N, Seki N, Yano K, Masuho Y, Saito T, Muramatsu M (Jun 1999). “Isolation and characterization of a novel human gene (HFB30) which encodes a protein with a RING finger motif”. Biochim Biophys Acta. 1445 (2): 232\u20136. doi:10.1016\/s0167-4781(99)00045-7. PMID\u00a010320776.^ a b EntrezGene 9604^ Ingham AB, Osborne SA, Menzies M, Briscoe S, Chen W, Kongsuwan K,  et\u00a0al. (January 2014). “RNF14 is a regulator of mitochondrial and immune function in muscle”. BMC Systems Biology. 8: 10. doi:10.1186\/1752-0509-8-10. PMC\u00a03906743. PMID\u00a024472305.^ Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C (Feb 2002). “A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth”. J. Biol. Chem. 277 (7): 4609\u201317. doi:10.1074\/jbc.M108312200. PMID\u00a011673464.^ He B, Minges JT, Lee LW, Wilson EM (Mar 2002). “The FXXLF motif mediates androgen receptor-specific interactions with coregulators”. J. Biol. Chem. 277 (12): 10226\u201335. doi:10.1074\/jbc.M111975200. PMID\u00a011779876.^ He B, Wilson EM (Mar 2003). “Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs”. Mol. Cell. Biol. 23 (6): 2135\u201350. doi:10.1128\/mcb.23.6.2135-2150.2003. PMC\u00a0149467. PMID\u00a012612084.Further reading[edit]Ueki N, Oda T, Kondo M, Yano K, Noguchi T, Muramatsu M (1999). “Selection system for genes encoding nuclear-targeted proteins”. Nat. Biotechnol. 16 (13): 1338\u201342. doi:10.1038\/4315. PMID\u00a09853615. S2CID\u00a020001769.Ito K, Adachi S, Iwakami R, Yasuda H, Muto Y, Seki N, Okano Y (2001). “N-Terminally extended human ubiquitin-conjugating enzymes (E2s) mediate the ubiquitination of RING-finger proteins, ARA54 and RNF8”. Eur. J. Biochem. 268 (9): 2725\u201332. doi:10.1046\/j.1432-1327.2001.02169.x. PMID\u00a011322894.Miyamoto H, Rahman M, Takatera H, Kang HY, Yeh S, Chang HC, Nishimura K, Fujimoto N, Chang C (2002). “A dominant-negative mutant of androgen receptor coregulator ARA54 inhibits androgen receptor-mediated prostate cancer growth”. J. Biol. Chem. 277 (7): 4609\u201317. doi:10.1074\/jbc.M108312200. PMID\u00a011673464.Ueda T, Mawji NR, Bruchovsky N, Sadar MD (2002). “Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells”. J. Biol. Chem. 277 (41): 38087\u201394. doi:10.1074\/jbc.M203313200. PMID\u00a012163482.He B, Wilson EM (2003). “Electrostatic Modulation in Steroid Receptor Recruitment of LXXLL and FXXLF Motifs”. Mol. Cell. Biol. 23 (6): 2135\u201350. doi:10.1128\/MCB.23.6.2135-2150.2003. PMC\u00a0149467. PMID\u00a012612084.Mestayer C, Blanch\u00e8re M, Jaubert F, Dufour B, Mowszowicz I (2003). “Expression of androgen receptor coactivators in normal and cancer prostate tissues and cultured cell lines”. Prostate. 56 (3): 192\u2013200. doi:10.1002\/pros.10229. PMID\u00a012772188. S2CID\u00a023253844.Wang L, Hsu CL, Ni J, Wang PH, Yeh S, Keng P, Chang C (2004). “Human Checkpoint Protein hRad9 Functions as a Negative Coregulator To Repress Androgen Receptor Transactivation in Prostate Cancer Cells”. Mol. Cell. Biol. 24 (5): 2202\u201313. doi:10.1128\/MCB.24.5.2202-2213.2004. PMC\u00a0350564. PMID\u00a014966297.Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (2004). “Functional Proteomics Mapping of a Human Signaling Pathway”. Genome Res. 14 (7): 1324\u201332. doi:10.1101\/gr.2334104. PMC\u00a0442148. PMID\u00a015231748.Lin DY, Fang HI, Ma AH, Huang YS, Pu YS, Jenster G, Kung HJ, Shih HM (2004). “Negative Modulation of Androgen Receptor Transcriptional Activity by Daxx”. Mol. Cell. Biol. 24 (24): 10529\u201341. doi:10.1128\/MCB.24.24.10529-10541.2004. PMC\u00a0533990. PMID\u00a015572661.Yang Z, Chang YJ, Miyamoto H, Ni J, Niu Y, Chen Z, Chen YL, Yao JL, di Sant’Agnese PA, Chang C (2007). “Transgelin functions as a suppressor via inhibition of ARA54-enhanced androgen receptor transactivation and prostate cancer cell growth”. Mol. Endocrinol. 21 (2): 343\u201358. doi:10.1210\/me.2006-0104. PMID\u00a017082327.Yang Z, Chang YJ, Miyamoto H, Yeh S, Yao JL, di Sant’Agnese PA, Tsai MY, Chang C (2007). “Suppression of androgen receptor transactivation and prostate cancer cell growth by heterogeneous nuclear ribonucleoprotein A1 via interaction with androgen receptor coregulator ARA54”. Endocrinology. 148 (3): 1340\u20139. doi:10.1210\/en.2006-0716. PMID\u00a017110431.Kikuchi H, Uchida C, Hattori T, Isobe T, Hiramatsu Y, Kitagawa K, Oda T, Konno H, Kitagawa M (2007). “ARA54 is involved in transcriptional regulation of the cyclin D1 gene in human cancer cells”. Carcinogenesis. 28 (8): 1752\u20138. doi:10.1093\/carcin\/bgm120. PMID\u00a017510080.External links[edit]This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rnf14-wikipedia\/#breadcrumbitem","name":"RNF14 – Wikipedia"}}]}]