[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rps6ka4-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/rps6ka4-wikipedia\/","headline":"RPS6KA4 – Wikipedia","name":"RPS6KA4 – Wikipedia","description":"From Wikipedia, the free encyclopedia Enzyme found in humans Ribosomal protein S6 kinase alpha-4 is an enzyme that in humans","datePublished":"2022-06-01","dateModified":"2022-06-01","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/rps6ka4-wikipedia\/","wordCount":3781,"articleBody":"From Wikipedia, the free encyclopediaEnzyme found in humansRibosomal protein S6 kinase alpha-4 is an enzyme that in humans is encoded by the RPS6KA4 gene.[5][6][7]Table of ContentsFunction[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine\/threonine kinases. This kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including CREB1 and c-Fos. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.[7]Interactions[edit]RPS6KA4 has been shown to interact with MAPK14.[5]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000162302 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000118668 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b Pierrat B, Correia JS, Mary JL, Tomas-Zuber M, Lesslauer W (Dec 1998). “RSK-B, a novel ribosomal S6 kinase family member, is a CREB kinase under dominant control of p38alpha mitogen-activated protein kinase (p38alphaMAPK)”. J Biol Chem. 273 (45): 29661\u201329671. doi:10.1074\/jbc.273.45.29661. PMID\u00a09792677.^ Deak M, Clifton AD, Lucocq LM, Alessi DR (Sep 1998). “Mitogen- and stress-activated protein kinase-1 (MSK1) is directly activated by MAPK and SAPK2\/p38, and may mediate activation of CREB”. EMBO J. 17 (15): 4426\u20134441. doi:10.1093\/emboj\/17.15.4426. PMC\u00a01170775. PMID\u00a09687510.^ a b “Entrez Gene: RPS6KA4 ribosomal protein S6 kinase, 90kDa, polypeptide 4”.Further reading[edit]Xing J, Ginty DD, Greenberg ME (1996). “Coupling of the RAS-MAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase”. Science. 273 (5277): 959\u2013963. Bibcode:1996Sci…273..959X. doi:10.1126\/science.273.5277.959. PMID\u00a08688081. S2CID\u00a022226803.Du K, Montminy M (1999). “CREB is a regulatory target for the protein kinase Akt\/PKB”. J. Biol. Chem. 273 (49): 32377\u201332379. doi:10.1074\/jbc.273.49.32377. PMID\u00a09829964.Tom\u00e1s-Zuber M, Mary JL, Lesslauer W (2000). “Control sites of ribosomal S6 kinase B and persistent activation through tumor necrosis factor”. J. Biol. Chem. 275 (31): 23549\u201323558. doi:10.1074\/jbc.M002586200. PMID\u00a010806207.Tom\u00e1s-Zuber M, Mary JL, Lamour F,  et\u00a0al. (2001). “C-terminal elements control location, activation threshold, and p38 docking of ribosomal S6 kinase B (RSKB)”. J. Biol. Chem. 276 (8): 5892\u20135899. doi:10.1074\/jbc.M005822200. PMID\u00a011035004.Gudi T, Casteel DE, Vinson C,  et\u00a0al. (2001). “NO activation of fos promoter elements requires nuclear translocation of G-kinase I and CREB phosphorylation but is independent of MAP kinase activation”. Oncogene. 19 (54): 6324\u20136333. doi:10.1038\/sj.onc.1204007. PMID\u00a011175347.Prymakowska-Bosak M, Misteli T, Herrera JE,  et\u00a0al. (2001). “Mitotic phosphorylation prevents the binding of HMGN proteins to chromatin”. Mol. Cell. Biol. 21 (15): 5169\u20135178. doi:10.1128\/MCB.21.15.5169-5178.2001. PMC\u00a087241. PMID\u00a011438671.Wiggin GR, Soloaga A, Foster JM,  et\u00a0al. (2002). “MSK1 and MSK2 are required for the mitogen- and stress-induced phosphorylation of CREB and ATF1 in fibroblasts”. Mol. Cell. Biol. 22 (8): 2871\u20132881. doi:10.1128\/MCB.22.8.2871-2881.2002. PMC\u00a0133730. PMID\u00a011909979.Soloaga A, Thomson S, Wiggin GR,  et\u00a0al. (2003). “MSK2 and MSK1 mediate the mitogen- and stress-induced phosphorylation of histone H3 and HMG-14”. EMBO J. 22 (11): 2788\u20132797. doi:10.1093\/emboj\/cdg273. PMC\u00a0156769. PMID\u00a012773393.Wissing J, J\u00e4nsch L, Nimtz M,  et\u00a0al. (2007). “Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry”. Mol. Cell. Proteomics. 6 (3): 537\u2013547. doi:10.1074\/mcp.T600062-MCP200. PMID\u00a017192257.Gesser B, Johansen C, Rasmussen MK,  et\u00a0al. (2007). “Dimethylfumarate specifically inhibits the mitogen and stress-activated kinases 1 and 2 (MSK1\/2): possible role for its anti-psoriatic effect”. J. Invest. Dermatol. 127 (9): 2129\u20132137. doi:10.1038\/sj.jid.5700859. PMID\u00a017495961.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/rps6ka4-wikipedia\/#breadcrumbitem","name":"RPS6KA4 – Wikipedia"}}]}]