[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/runx1t1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/runx1t1-wikipedia\/","headline":"RUNX1T1 – Wikipedia","name":"RUNX1T1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens RUNX1T1 Identifiers Aliases RUNX1T1, AML1T1, CBFA2T1,","datePublished":"2019-09-26","dateModified":"2019-09-26","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/bc\/Protein_RUNX1T1_PDB_1wq6.png\/250px-Protein_RUNX1T1_PDB_1wq6.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/b\/bc\/Protein_RUNX1T1_PDB_1wq6.png\/250px-Protein_RUNX1T1_PDB_1wq6.png","height":"52","width":"250"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/runx1t1-wikipedia\/","about":["Wiki"],"wordCount":9212,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensRUNX1T1IdentifiersAliasesRUNX1T1, AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2, AML1-MTG8, t(8;21)(q22;q22), RUNX1 translocation partner 1, RUNX1 partner transcriptional co-repressor 1External IDsOMIM: 133435 MGI: 104793 HomoloGene: 3801 GeneCards: RUNX1T1 WikidataProtein CBFA2T1 is a protein that in humans is encoded by the RUNX1T1 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsFunction[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5′-region of the RUNX1 gene fused to the 3′-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor\/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.[7]Interactions[edit]RUNX1T1 has been shown to interact with:       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000079102 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000006586 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Erickson P, Gao J, Chang KS, Look T, Whisenant E, Raimondi S, Lasher R, Trujillo J, Rowley J, Drabkin H (October 1992). “Identification of breakpoints in t(8;21) acute myelogenous leukemia and isolation of a fusion transcript, AML1\/ETO, with similarity to Drosophila segmentation gene, runt”. Blood. 80 (7): 1825\u201331. doi:10.1182\/blood.V80.7.1825.1825. PMID\u00a01391946.^ Calabi F, Cilli V (Dec 1998). “CBFA2T1, a gene rearranged in human leukemia, is a member of a multigene family”. Genomics. 52 (3): 332\u2013341. doi:10.1006\/geno.1998.5429. PMID\u00a09790752.^ a b “Entrez Gene: RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related)”.^ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.^ a b ^ a b Hoogeveen AT, Rossetti S, Stoyanova V, Schonkeren J, Fenaroli A, Schiaffonati L, van Unen L, Sacchi N (September 2002). “The transcriptional corepressor MTG16a contains a novel nucleolar targeting sequence deranged in t (16; 21)-positive myeloid malignancies”. Oncogene. 21 (43): 6703\u201312. doi:10.1038\/sj.onc.1205882. PMID\u00a012242670.^ Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M (Dec 2002). “AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor”. Cancer Res. 62 (23): 7050\u20138. PMID\u00a012460926.^ McGhee L, Bryan J, Elliott L, Grimes HL, Kazanjian A, Davis JN, Meyers S (August 2003). “Gfi-1 attaches to the nuclear matrix, associates with ETO (MTG8) and histone deacetylase proteins, and represses transcription using a TSA-sensitive mechanism”. J. Cell. Biochem. 89 (5): 1005\u201318. doi:10.1002\/jcb.10548. PMID\u00a012874834. S2CID\u00a025450754.^ Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW (October 2001). “ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain”. Mol. Cell. Biol. 21 (19): 6470\u201383. doi:10.1128\/mcb.21.19.6470-6483.2001. PMC\u00a099794. PMID\u00a011533236.^ a b Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA (January 2001). “Oligomerization of ETO is obligatory for corepressor interaction”. Mol. Cell. Biol. 21 (1): 156\u201363. doi:10.1128\/MCB.21.1.156-163.2001. PMC\u00a088789. PMID\u00a011113190.^ Takahashi S, McConnell MJ, Harigae H, Kaku M, Sasaki T, Melnick AM, Licht JD (June 2004). “The Flt3 internal tandem duplication mutant inhibits the function of transcriptional repressors by blocking interactions with SMRT”. Blood. 103 (12): 4650\u20138. doi:10.1182\/blood-2003-08-2759. PMID\u00a014982881.^ Fukuyama T, Sueoka E, Sugio Y, Otsuka T, Niho Y, Akagi K, Kozu T (September 2001). “MTG8 proto-oncoprotein interacts with the regulatory subunit of type II cyclic AMP-dependent protein kinase in lymphocytes”. Oncogene. 20 (43): 6225\u201332. doi:10.1038\/sj.onc.1204794. PMID\u00a011593431.^ Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD (March 2000). “The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein”. Mol. Cell. Biol. 20 (6): 2075\u201386. doi:10.1128\/mcb.20.6.2075-2086.2000. PMC\u00a0110824. PMID\u00a010688654.^ Melnick A, Carlile GW, McConnell MJ, Polinger A, Hiebert SW, Licht JD (Dec 2000). “AML-1\/ETO fusion protein is a dominant negative inhibitor of transcriptional repression by the promyelocytic leukemia zinc finger protein”. Blood. 96 (12): 3939\u201347. doi:10.1182\/blood.V96.12.3939. PMID\u00a011090081.Further reading[edit]Ferrara F, Del Vecchio L (2002). “Acute myeloid leukemia with t(8;21)\/AML1\/ETO: a distinct biological and clinical entity”. Haematologica. 87 (3): 306\u201319. PMID\u00a011869944.Nisson PE, Watkins PC, Sacchi N (1992). “Transcriptionally active chimeric gene derived from the fusion of the AML1 gene and a novel gene on chromosome 8 in t(8;21) leukemic cells”. Cancer Genet. Cytogenet. 63 (2): 81\u201388. doi:10.1016\/0165-4608(92)90384-K. PMID\u00a01423235.Era T, Asou N, Kunisada T, Yamasaki H, Asou H, Kamada N, Nishikawa S, Yamaguchi K, Takatsuki K (1995). “Identification of two transcripts of AML1\/ETO-fused gene in t(8;21) leukemic cells and expression of wild-type ETO gene in hematopoietic cells”. Genes Chromosomes Cancer. 13 (1): 25\u201333. doi:10.1002\/gcc.2870130105. PMID\u00a07541640. S2CID\u00a041918020.Tighe JE, Calabi F (1994). “Alternative, out-of-frame runt\/MTG8 transcripts are encoded by the derivative (8) chromosome in the t(8;21) of acute myeloid leukemia M2”. Blood. 84 (7): 2115\u201321. doi:10.1182\/blood.V84.7.2115.2115. PMID\u00a07919324.Erickson PF, Robinson M, Owens G, Drabkin HA (1994). “The ETO portion of acute myeloid leukemia t(8;21) fusion transcript encodes a highly evolutionarily conserved, putative transcription factor”. Cancer Res. 54 (7): 1782\u20136. PMID\u00a08137293.Miyoshi H, Kozu T, Shimizu K, Enomoto K, Maseki N, Kaneko Y, Kamada N, Ohki M (1993). “The t(8;21) translocation in acute myeloid leukemia results in production of an AML1-MTG8 fusion transcript”. EMBO J. 12 (7): 2715\u201321. doi:10.1002\/j.1460-2075.1993.tb05933.x. PMC\u00a0413521. PMID\u00a08334990.Kozu T, Miyoshi H, Shimizu K, Maseki N, Kaneko Y, Asou H, Kamada N, Ohki M (1993). “Junctions of the AML1\/MTG8(ETO) fusion are constant in t(8;21) acute myeloid leukemia detected by reverse transcription polymerase chain reaction”. Blood. 82 (4): 1270\u20136. doi:10.1182\/blood.V82.4.1270.1270. PMID\u00a08353289.Niwa-Kawakita M, Miyoshi H, Gotoh O, Matsushima Y, Nishimura M, Shisa H, Ohki M (1996). “Cloning and gene mapping of the mouse homologue of the CBFA2T1 gene associated with human acute myeloid leukemia”. Genomics. 29 (3): 755\u2013759. doi:10.1006\/geno.1995.9941. PMID\u00a08575770.Erickson PF, Dessev G, Lasher RS, Philips G, Robinson M, Drabkin HA (1996). “ETO and AML1 phosphoproteins are expressed in CD34+ hematopoietic progenitors: implications for t(8;21) leukemogenesis and monitoring residual disease”. Blood. 88 (5): 1813\u201323. doi:10.1182\/blood.V88.5.1813.1813. PMID\u00a08781439.Wolford JK, Bogardus C, Prochazka M (1998). “Polymorphism in the 3′ untranslated region of MTG8 is associated with obesity in Pima Indian males”. Biochem. Biophys. Res. Commun. 246 (3): 624\u2013626. doi:10.1006\/bbrc.1998.8683. PMID\u00a09618262.Sacchi N, Tamanini F, Willemsen R, Denis-Donini S, Campiglio S, Hoogeveen AT (1998). “Subcellular localization of the oncoprotein MTG8 (CDR\/ETO) in neural cells”. Oncogene. 16 (20): 2609\u20132615. doi:10.1038\/sj.onc.1201824. PMID\u00a09632137.Wolford JK, Prochazka M (1998). “Structure and expression of the human MTG8\/ETO gene”. Gene. 212 (1): 103\u2013109. doi:10.1016\/S0378-1119(98)00141-3. PMID\u00a09661669.Komori A, Sueoka E, Fujiki H, Ishii M, Kozu T (1999). “Association of MTG8 (ETO\/CDR), a leukemia-related protein, with serine\/threonine protein kinases and heat shock protein HSP90 in human hematopoietic cell lines”. Jpn. J. Cancer Res. 90 (1): 60\u20138. doi:10.1111\/j.1349-7006.1999.tb00666.x. PMC\u00a05925983. PMID\u00a010076566.Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M (2000). “Structure and expression pattern of a human MTG8\/ETO family gene, MTGR1”. Gene. 241 (2): 287\u2013295. doi:10.1016\/S0378-1119(99)00481-3. PMID\u00a010675041.Melnick AM, Westendorf JJ, Polinger A, Carlile GW, Arai S, Ball HJ, Lutterbach B, Hiebert SW, Licht JD (2000). “The ETO protein disrupted in t(8;21)-associated acute myeloid leukemia is a corepressor for the promyelocytic leukemia zinc finger protein”. Mol. Cell. Biol. 20 (6): 2075\u20132086. doi:10.1128\/MCB.20.6.2075-2086.2000. PMC\u00a0110824. PMID\u00a010688654.Miyamoto T, Weissman IL, Akashi K (2000). “AML1\/ETO-expressing nonleukemic stem cells in acute myelogenous leukemia with 8;21 chromosomal translocation”. Proc. Natl. Acad. Sci. U.S.A. 97 (13): 7521\u20137526. Bibcode:2000PNAS…97.7521M. doi:10.1073\/pnas.97.13.7521. PMC\u00a016578. PMID\u00a010861016.Odaka Y, Mally A, Elliott LT, Meyers S (2000). “Nuclear import and subnuclear localization of the proto-oncoprotein ETO (MTG8)”. Oncogene. 19 (32): 3584\u20133597. doi:10.1038\/sj.onc.1203689. PMID\u00a010951564.Wood JD, Nucifora FC, Duan K, Zhang C, Wang J, Kim Y, Schilling G, Sacchi N, Liu JM, Ross CA (2000). “Atrophin-1, the dentato-rubral and pallido-luysian atrophy gene product, interacts with ETO\/MTG8 in the nuclear matrix and represses transcription”. J. Cell Biol. 150 (5): 939\u2013948. doi:10.1083\/jcb.150.5.939. PMC\u00a02175251. PMID\u00a010973986.PDB gallery1wq6: The tetramer structure of the nervy homolgy two (NHR2) domain of AML1-ETO is critical for AML1-ETO’S activity2dj8: Solution Structure of zf-MYND Domain of Protein CBFA2TI (Protein MTG8)2h7b: Solution structure of the eTAFH domain from the human leukemia-associated fusion protein AML1-ETO       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/runx1t1-wikipedia\/#breadcrumbitem","name":"RUNX1T1 – Wikipedia"}}]}]