[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/sart3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/sart3-wikipedia\/","headline":"SART3 – Wikipedia","name":"SART3 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens SART3 Identifiers Aliases SART3, DSAP1, P100, RP11-13G14, TIP110,","datePublished":"2019-08-17","dateModified":"2019-08-17","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/73\/Protein_SART3_PDB_2do4.png\/250px-Protein_SART3_PDB_2do4.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/7\/73\/Protein_SART3_PDB_2do4.png\/250px-Protein_SART3_PDB_2do4.png","height":"186","width":"250"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/sart3-wikipedia\/","about":["Wiki"],"wordCount":6422,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensSART3IdentifiersAliasesSART3, DSAP1, P100, RP11-13G14, TIP110, p110, p110(nrb), squamous cell carcinoma antigen recognized by T-cells 3, squamous cell carcinoma antigen recognized by T cells 3, spliceosome associated factor 3, U4\/U6 recycling proteinExternal IDsOMIM: 611684 MGI: 1858230 HomoloGene: 40977 GeneCards: SART3 WikidataSquamous cell carcinoma antigen recognized by T-cells 3 is a protein that in humans is encoded by the SART3 gene.[5][6][7]The protein encoded by this gene is an RNA-binding nuclear protein that is a tumor-rejection antigen. This antigen possesses tumor epitopes capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes in cancer patients and may be useful for specific immunotherapy. This gene product is found to be an important cellular factor for HIV-1 gene expression and viral replication. It also associates transiently with U6 and U4\/U6 snRNPs during the recycling phase of the spliceosome cycle. This encoded protein is thought to be involved in the regulation of mRNA splicing.[7]Interactions[edit]SART3 has been shown to interact with RNPS1[8] and Androgen receptor.[9]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000075856 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018974 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Nagase T, Seki N, Tanaka A, Ishikawa K, Nomura N (August 1995). “Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1”. DNA Research. 2 (4): 167\u201374, 199\u2013210. doi:10.1093\/dnares\/2.4.167. PMID\u00a08590280.^ Harada K, Yamada A, Mine T, Kawagoe N, Takasu H, Itoh K (February 2000). “Mouse homologue of the human SART3 gene encoding tumor-rejection antigen”. Japanese Journal of Cancer Research. 91 (2): 239\u201347. doi:10.1111\/j.1349-7006.2000.tb00937.x. PMC\u00a05926322. PMID\u00a010761712.^ a b “Entrez Gene: SART3 squamous cell carcinoma antigen recognized by T cells 3”.^ Harada K, Yamada A, Yang D, Itoh K, Shichijo S (September 2001). “Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation”. International Journal of Cancer. 93 (5): 623\u20138. doi:10.1002\/ijc.1391. PMID\u00a011477570. S2CID\u00a024724555.^ Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ (May 2004). “Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation”. The Journal of Biological Chemistry. 279 (21): 21766\u201373. doi:10.1074\/jbc.M314321200. PMID\u00a015031286.Further reading[edit]Maruyama K, Sugano S (January 1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Yang D, Nakao M, Shichijo S, Sasatomi T, Takasu H, Matsumoto H, Mori K, Hayashi A, Yamana H, Shirouzu K, Itoh K (August 1999). “Identification of a gene coding for a protein possessing shared tumor epitopes capable of inducing HLA-A24-restricted cytotoxic T lymphocytes in cancer patients”. Cancer Research. 59 (16): 4056\u201363. PMID\u00a010463607.Tanaka S, Tsuda N, Kawano K, Sakamoto M, Nishida T, Hashimoto T, Shichijo S, Kamura T, Itoh K (November 2000). “Expression of tumor-rejection antigens in gynecologic cancers”. Japanese Journal of Cancer Research. 91 (11): 1177\u201384. doi:10.1111\/j.1349-7006.2000.tb00902.x. PMC\u00a05926290. PMID\u00a011092984.Harada K, Yamada A, Yang D, Itoh K, Shichijo S (September 2001). “Binding of a SART3 tumor-rejection antigen to a pre-mRNA splicing factor RNPS1: a possible regulation of splicing by a complex formation”. International Journal of Cancer. 93 (5): 623\u20138. doi:10.1002\/ijc.1391. PMID\u00a011477570. S2CID\u00a024724555.Sasatomi T, Suefuji Y, Matsunaga K, Yamana H, Miyagi Y, Araki Y, Ogata Y, Itoh K, Shirouzu K (March 2002). “Expression of tumor rejection antigens in colorectal carcinomas”. Cancer. 94 (6): 1636\u201341. doi:10.1002\/cncr.10421. PMID\u00a011920522. S2CID\u00a033045822.Liu Y, Li J, Kim BO, Pace BS, He JJ (June 2002). “HIV-1 Tat protein-mediated transactivation of the HIV-1 long terminal repeat promoter is potentiated by a novel nuclear Tat-interacting protein of 110 kDa, Tip110”. The Journal of Biological Chemistry. 277 (26): 23854\u201363. doi:10.1074\/jbc.M200773200. PMID\u00a011959860.Bell M, Schreiner S, Damianov A, Reddy R, Bindereif A (June 2002). “p110, a novel human U6 snRNP protein and U4\/U6 snRNP recycling factor”. The EMBO Journal. 21 (11): 2724\u201335. doi:10.1093\/emboj\/21.11.2724. PMC\u00a0126028. PMID\u00a012032085.Nottrott S, Urlaub H, L\u00fchrmann R (October 2002). “Hierarchical, clustered protein interactions with U4\/U6 snRNA: a biochemical role for U4\/U6 proteins”. The EMBO Journal. 21 (20): 5527\u201338. doi:10.1093\/emboj\/cdf544. PMC\u00a0129076. PMID\u00a012374753.Nakayama M, Kikuno R, Ohara O (November 2002). “Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs”. Genome Research. 12 (11): 1773\u201384. doi:10.1101\/gr.406902. PMC\u00a0187542. PMID\u00a012421765.Stan\u0115k D, Rader SD, Klingauf M, Neugebauer KM (February 2003). “Targeting of U4\/U6 small nuclear RNP assembly factor SART3\/p110 to Cajal bodies”. The Journal of Cell Biology. 160 (4): 505\u201316. doi:10.1083\/jcb.200210087. PMC\u00a02173746. PMID\u00a012578909.Damianov A, Schreiner S, Bindereif A (February 2004). “Recycling of the U12-type spliceosome requires p110, a component of the U6atac snRNP”. Molecular and Cellular Biology. 24 (4): 1700\u20138. doi:10.1128\/MCB.24.4.1700-1708.2004. PMC\u00a0344176. PMID\u00a014749385.Liu Y, Kim BO, Kao C, Jung C, Dalton JT, He JJ (May 2004). “Tip110, the human immunodeficiency virus type 1 (HIV-1) Tat-interacting protein of 110 kDa as a negative regulator of androgen receptor (AR) transcriptional activation”. The Journal of Biological Chemistry. 279 (21): 21766\u201373. doi:10.1074\/jbc.M314321200. PMID\u00a015031286.Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW (June 2004). “Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation”. Nature Biotechnology. 22 (6): 707\u201316. doi:10.1038\/nbt971. PMID\u00a015146197. S2CID\u00a027764390.Medenbach J, Schreiner S, Liu S, L\u00fchrmann R, Bindereif A (September 2004). “Human U4\/U6 snRNP recycling factor p110: mutational analysis reveals the function of the tetratricopeptide repeat domain in recycling”. Molecular and Cellular Biology. 24 (17): 7392\u2013401. doi:10.1128\/MCB.24.17.7392-7401.2004. PMC\u00a0506986. PMID\u00a015314151.Stan\u0115k D, Neugebauer KM (September 2004). “Detection of snRNP assembly intermediates in Cajal bodies by fluorescence resonance energy transfer”. The Journal of Cell Biology. 166 (7): 1015\u201325. doi:10.1083\/jcb.200405160. PMC\u00a02172029. PMID\u00a015452143.PDB gallery2do4: Solution structure of the RNA binding domain of squamous cell carcinoma antigen recognized by T cells 3  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/sart3-wikipedia\/#breadcrumbitem","name":"SART3 – Wikipedia"}}]}]