[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/semenogelin-i-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/semenogelin-i-wikipedia\/","headline":"Semenogelin I – Wikipedia","name":"Semenogelin I – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Semenogelin-1 is a protein that in humans is","datePublished":"2014-08-18","dateModified":"2014-08-18","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/semenogelin-i-wikipedia\/","wordCount":4035,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensSemenogelin-1 is a protein that in humans is encoded by the SEMG1 gene.[3][4][5]The protein encoded by this gene is the predominant protein in semen. The encoded secreted protein is involved in the formation of a gel matrix that encases ejaculated spermatozoa. The prostate-specific antigen (PSA) protease processes this protein into smaller peptides, with each possibly having a separate function. The proteolysis process breaks down the gel matrix and allows the spermatozoa to move more freely. Two transcript variants encoding different isoforms have been found for this gene.[5]See also[edit]References[edit]Further reading[edit]Robert M; Gagnon C (1999). “Semenogelin I: a coagulum forming, multifunctional seminal vesicle protein”. Cell. Mol. Life Sci. 55 (6\u20137): 944\u201360. doi:10.1007\/s000180050346. PMID\u00a010412373. S2CID\u00a031516685.Ulvsb\u00e4ck M, Lazure C, Lilja H,  et\u00a0al. (1992). “Gene structure of semenogelin I and II. The predominant proteins in human semen are encoded by two homologous genes on chromosome 20”. J. Biol. Chem. 267 (25): 18080\u20134. doi:10.1016\/S0021-9258(19)37155-8. PMID\u00a01517240.Schneider K, Kausler W, Tripier D,  et\u00a0al. (1989). “[Isolation and structure determination of two peptides occurring in human seminal plasma]”. Biol. Chem. Hoppe-Seyler. 370 (4): 353\u20136. doi:10.1515\/bchm3.1989.370.1.353. PMID\u00a02757795.Li CH; Hammonds RG; Ramasharma K; Chung D (1985). “Human seminal alpha inhibins: isolation, characterization, and structure”. Proc. Natl. Acad. Sci. U.S.A. 82 (12): 4041\u20134. Bibcode:1985PNAS…82.4041L. doi:10.1073\/pnas.82.12.4041. PMC\u00a0397930. PMID\u00a03889920.Lilja H; Jeppsson JO (1985). “Amino acid sequence of the predominant basic protein in human seminal plasma”. FEBS Lett. 182 (1): 181\u20134. doi:10.1016\/0014-5793(85)81179-0. PMID\u00a03972122. S2CID\u00a031277428.Ramasharma K, Sairam MR, Seidah NG,  et\u00a0al. (1984). “Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity”. Science. 223 (4641): 1199\u2013202. Bibcode:1984Sci…223.1199R. doi:10.1126\/science.6422553. PMID\u00a06422553.Lilja H; Laurell CB; Jeppsson JO (1984). “Characterization of the predominant basic protein in human seminal plasma, one cleavage product of the major seminal vesicle protein”. Scand. J. Clin. Lab. Invest. 44 (5): 439\u201346. doi:10.3109\/00365518409083835. PMID\u00a06484484.Seidah NG; Ramasharma K; Sairam MR; Chr\u00e9tien M (1984). “Partial amino acid sequence of a human seminal plasma peptide with inhibin-like activity”. FEBS Lett. 167 (1): 98\u2013102. doi:10.1016\/0014-5793(84)80840-6. PMID\u00a06698208. S2CID\u00a027647296.Khan Z; Smyth DG (1993). “Isolation and identification of N-terminally extended forms of 5-oxoprolylglutamylprolinamide (Glp-Glu-Pro-NH2), a thyrotropin-releasing-hormone (TRH)-like peptide present in human semen”. Eur. J. Biochem. 212 (1): 35\u201340. doi:10.1111\/j.1432-1033.1993.tb17629.x. PMID\u00a08444163.Lundwall A (1996). “The structure of the semenogelin gene locus–nucleotide sequence of the intergenic and the flanking DNA”. Eur. J. Biochem. 235 (3): 466\u201370. doi:10.1111\/j.1432-1033.1996.00466.x. PMID\u00a08654389.Malm J, Hellman J, Magnusson H,  et\u00a0al. (1996). “Isolation and characterization of the major gel proteins in human semen, semenogelin I and semenogelin II”. Eur. J. Biochem. 238 (1): 48\u201353. doi:10.1111\/j.1432-1033.1996.0048q.x. PMID\u00a08665951.Bjartell A, Malm J, Moller C,  et\u00a0al. (1997). “Distribution and tissue expression of semenogelin I and II in man as demonstrated by in situ hybridization and immunocytochemistry”. J. Androl. 17 (1): 17\u201326. PMID\u00a08833737.Robert M; Gibbs BF; Jacobson E; Gagnon C (1997). “Characterization of prostate-specific antigen proteolytic activity on its major physiological substrate, the sperm motility inhibitor precursor\/semenogelin I.”. Biochemistry. 36 (13): 3811\u20139. doi:10.1021\/bi9626158. PMID\u00a09092810.Peter A; Lilja H; Lundwall A; Malm J (1998). “Semenogelin I and semenogelin II, the major gel-forming proteins in human semen, are substrates for transglutaminase”. Eur. J. Biochem. 252 (2): 216\u201321. doi:10.1046\/j.1432-1327.1998.2520216.x. PMID\u00a09523691.L\u00f6vgren J; Airas K; Lilja H (1999). “Enzymatic action of human glandular kallikrein 2 (hK2). Substrate specificity and regulation by Zn2+ and extracellular protease inhibitors”. Eur. J. Biochem. 262 (3): 781\u20139. doi:10.1046\/j.1432-1327.1999.00433.x. PMID\u00a010411640.Malm J; Hellman J; Hogg P; Lilja H (2000). “Enzymatic action of prostate-specific antigen (PSA or hK3): substrate specificity and regulation by Zn(2+), a tight-binding inhibitor”. Prostate. 45 (2): 132\u20139. doi:10.1002\/1097-0045(20001001)45:23.0.CO;2-3. PMID\u00a011027412. S2CID\u00a035309283.Deloukas P, Matthews LH, Ashurst J,  et\u00a0al. (2002). “The DNA sequence and comparative analysis of human chromosome 20”. Nature. 414 (6866): 865\u201371. Bibcode:2001Natur.414..865D. doi:10.1038\/414865a. PMID\u00a011780052.Brillard-Bourdet M, R\u00e9hault S, Juliano L,  et\u00a0al. (2002). “Amidolytic activity of prostatic acid phosphatase on human semenogelins and semenogelin-derived synthetic substrates”. Eur. J. Biochem. 269 (1): 390\u20135. doi:10.1046\/j.0014-2956.2001.02667.x. PMID\u00a011784334.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/semenogelin-i-wikipedia\/#breadcrumbitem","name":"Semenogelin I – Wikipedia"}}]}]