[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/sf3a2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/sf3a2-wikipedia\/","headline":"SF3A2 – Wikipedia","name":"SF3A2 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Splicing factor 3A subunit 2 is a protein","datePublished":"2019-08-06","dateModified":"2019-08-06","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/sf3a2-wikipedia\/","wordCount":5432,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensSplicing factor 3A subunit 2 is a protein that in humans is encoded by the SF3A2 gene.[3][4][5]Table of ContentsFunction[edit]Interactions[edit]References[edit]Further reading[edit]Function[edit]This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.[5]Interactions[edit]SF3A2 has been shown to interact with DDX46.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000104897 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Bennett M, Reed R (October 1993). “Correspondence between a mammalian spliceosome component and an essential yeast splicing factor”. Science. 262 (5130): 105\u20138. Bibcode:1993Sci…262..105B. doi:10.1126\/science.8211113. PMID\u00a08211113.^ Dresser DW, Hacker A, Lovell-Badge R, Guerrier D (September 1995). “The genes for a spliceosome protein (SAP62) and the anti-M\u00fcllerian hormone (AMH) are contiguous”. Human Molecular Genetics. 4 (9): 1613\u20138. doi:10.1093\/hmg\/4.9.1613. PMID\u00a08541848.^ a b “Entrez Gene: SF3A2 splicing factor 3a, subunit 2, 66kDa”.^ Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, L\u00fchrmann R (September 2002). “Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein”. The EMBO Journal. 21 (18): 4978\u201388. doi:10.1093\/emboj\/cdf480. PMC\u00a0126279. PMID\u00a012234937.Further reading[edit]Chiara MD, Champion-Arnaud P, Buvoli M, Nadal-Ginard B, Reed R (July 1994). “Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114”. Proceedings of the National Academy of Sciences of the United States of America. 91 (14): 6403\u20137. Bibcode:1994PNAS…91.6403C. doi:10.1073\/pnas.91.14.6403. PMC\u00a044210. PMID\u00a08022796.Rain JC, Tartakoff AM, Kr\u00e4mer A, Legrain P (June 1996). “Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution”. RNA. 2 (6): 535\u201350. PMC\u00a01369393. PMID\u00a08718683.Hong W, Bennett M, Xiao Y, Feld Kramer R, Wang C, Reed R (January 1997). “Association of U2 snRNP with the spliceosomal complex E”. Nucleic Acids Research. 25 (2): 354\u201361. doi:10.1093\/nar\/25.2.354. PMC\u00a0146436. PMID\u00a09016565.Moraitou M, Patrinou-Georgoula M, Guialis A (May 1998). “Structural\/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles”. The Biochemical Journal. 332 (1): 135\u201344. doi:10.1042\/bj3320135. PMC\u00a01219461. PMID\u00a09576861.Yan D, Perriman R, Igel H, Howe KJ, Neville M, Ares M (September 1998). “CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif”. Molecular and Cellular Biology. 18 (9): 5000\u20139. doi:10.1128\/mcb.18.9.5000. PMC\u00a0109085. PMID\u00a09710584.Neubauer G, King A, Rappsilber J, Calvio C, Watson M, Ajuh P, Sleeman J, Lamond A, Mann M (September 1998). “Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex”. Nature Genetics. 20 (1): 46\u201350. doi:10.1038\/1700. PMID\u00a09731529. S2CID\u00a0585778.Kr\u00e4mer A, Gr\u00fcter P, Gr\u00f6ning K, Kastner B (June 1999). “Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP”. The Journal of Cell Biology. 145 (7): 1355\u201368. doi:10.1083\/jcb.145.7.1355. PMC\u00a02133165. PMID\u00a010385517.Das R, Zhou Z, Reed R (May 2000). “Functional association of U2 snRNP with the ATP-independent spliceosomal complex E”. Molecular Cell. 5 (5): 779\u201387. doi:10.1016\/S1097-2765(00)80318-4. PMID\u00a010882114.Will CL, Schneider C, MacMillan AM, Katopodis NF, Neubauer G, Wilm M, L\u00fchrmann R, Query CC (August 2001). “A novel U2 and U11\/U12 snRNP protein that associates with the pre-mRNA branch site”. The EMBO Journal. 20 (16): 4536\u201346. doi:10.1093\/emboj\/20.16.4536. PMC\u00a0125580. PMID\u00a011500380.Nesic D, Kr\u00e4mer A (October 2001). “Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation”. Molecular and Cellular Biology. 21 (19): 6406\u201317. doi:10.1128\/MCB.21.19.6406-6417.2001. PMC\u00a099788. PMID\u00a011533230.Dresser DW, Jamin SP, Atkins CJ, Guerrier D (October 2001). “An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH”. Gene. 277 (1\u20132): 163\u201373. doi:10.1016\/S0378-1119(01)00690-4. PMID\u00a011602354.Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ (April 2002). “Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis”. RNA. 8 (4): 426\u201339. doi:10.1017\/S1355838202021088. PMC\u00a01370266. PMID\u00a011991638.Will CL, Urlaub H, Achsel T, Gentzel M, Wilm M, L\u00fchrmann R (September 2002). “Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein”. The EMBO Journal. 21 (18): 4978\u201388. doi:10.1093\/emboj\/cdf480. PMC\u00a0126279. PMID\u00a012234937.Takenaka K, Nakagawa H, Miyamoto S, Miki H (August 2004). “The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein”. The Biochemical Journal. 382 (Pt 1): 223\u201330. doi:10.1042\/BJ20040521. PMC\u00a01133934. PMID\u00a015142036.Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (July 2004). “Functional proteomics mapping of a human signaling pathway”. Genome Research. 14 (7): 1324\u201332. doi:10.1101\/gr.2334104. PMC\u00a0442148. PMID\u00a015231748.Nesic D, Tanackovic G, Kr\u00e4mer A (September 2004). “A role for Cajal bodies in the final steps of U2 snRNP biogenesis”. Journal of Cell Science. 117 (Pt 19): 4423\u201333. doi:10.1242\/jcs.01308. PMID\u00a015316075.  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