[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/spock1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/spock1-wikipedia\/","headline":"SPOCK1 – Wikipedia","name":"SPOCK1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens SPOCK1 Identifiers Aliases SPOCK1, SPOCK, TESTICAN, TIC1, sparc\/osteonectin,","datePublished":"2016-08-09","dateModified":"2016-08-09","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/spock1-wikipedia\/","about":["Wiki"],"wordCount":4221,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensSPOCK1IdentifiersAliasesSPOCK1, SPOCK, TESTICAN, TIC1, sparc\/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1, SPARC\/osteonectin, cwcv and kazal like domains proteoglycan 1, SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1External IDsOMIM: 602264 MGI: 105371 HomoloGene: 80193 GeneCards: SPOCK1 RNA expression patternBgeeHumanMouse (ortholog)Top expressed instromal cell of endometriumpostcentral gyrusBrodmann area 46orbitofrontal cortexcerebellar cortexcerebellar hemispheresuperior frontal gyrusentorhinal cortexinferior olivary nucleusponsTop expressed inmedial dorsal nucleusmedial geniculate nucleussuperior frontal gyrusolfactory epitheliumcerebellar cortexanterior horn of spinal cordlateral geniculate nucleusprimary motor cortexprefrontal cortexdorsomedial hypothalamic nucleusMore reference expression dataBioGPSWikidataTestican-1 is a protein that in humans is encoded by the SPOCK1 gene.[5][6]This gene encodes the protein core of a seminal plasma proteoglycan containing chondroitin- and heparan-sulfate chains. The protein’s function is under research, though it is from the same family of glycoproteins as SPARC. It is thought its similarity to thyropin-type cysteine protease inhibitors suggests its function may be related to protease inhibition.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000152377 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000056222 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Charbonnier F, Perin JP, Mattei MG, Camuzat A, Bonnet F, Gressin L, Alliel PM (Jun 1998). “Genomic organization of the human SPOCK gene and its chromosomal localization to 5q31”. Genomics. 48 (3): 377\u201380. doi:10.1006\/geno.1997.5199. PMID\u00a09545645.^ a b “Entrez Gene: SPOCK1 sparc\/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1”.Further reading[edit]P\u00e9rin JP, Alliel PM, Joll\u00e8s P, Bonnet F (1994). “Proteoglycans in male reproductive tract”. EXS. 70: 191\u20137. doi:10.1007\/978-3-0348-7545-5_11. ISBN\u00a0978-3-0348-7547-9. PMID\u00a07507743.Charbonnier F, P\u00e9rin JP, Roussel G,  et\u00a0al. (1997). “[Cloning of testican\/SPOCK in man and mouse. Neuromuscular expression perspectives in pathology]”. C. R. S\u00e9ances Soc. Biol. Fil. 191 (1): 127\u201333. PMID\u00a09181134.Alliel PM, Perin JP, Joll\u00e8s P, Bonnet FJ (1993). “Testican, a multidomain testicular proteoglycan resembling modulators of cell social behaviour”. Eur. J. Biochem. 214 (1): 347\u201350. doi:10.1111\/j.1432-1033.1993.tb17930.x. PMID\u00a08389704.Bonnet F, P\u00e9rin JP, Charbonnier F,  et\u00a0al. (1996). “Structure and cellular distribution of mouse brain testican. Association with the postsynaptic area of hippocampus pyramidal cells”. J. Biol. Chem. 271 (8): 4373\u201380. doi:10.1074\/jbc.271.8.4373. PMID\u00a08626787.Marr HS, Basalamah MA, Edgell CJ (1998). “Endothelial cell expression of testican mRNA”. Endothelium. 5 (3): 209\u201319. doi:10.3109\/10623329709053399. PMID\u00a09272383.Kohfeldt E, Maurer P, Vannahme C, Timpl R (1997). “Properties of the extracellular calcium binding module of the proteoglycan testican”. FEBS Lett. 414 (3): 557\u201361. doi:10.1016\/S0014-5793(97)01070-3. PMID\u00a09323035. S2CID\u00a025552375.Marr HS, Basalamah MA, Bouldin TW,  et\u00a0al. (2001). “Distribution of testican expression in human brain”. Cell Tissue Res. 302 (2): 139\u201344. doi:10.1007\/s004410000277. PMID\u00a011131125. S2CID\u00a09937680.BaSalamah MA, Marr HS, Duncan AW, Edgell CJ (2001). “Testican in human blood”. Biochem. Biophys. Res. Commun. 283 (5): 1083\u201390. doi:10.1006\/bbrc.2001.4900. PMID\u00a011355883.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Nakada M, Miyamori H, Yamashita J, Sato H (2003). “Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins”. Cancer Res. 63 (12): 3364\u20139. PMID\u00a012810672.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Schmutz J, Martin J, Terry A,  et\u00a0al. (2004). “The DNA sequence and comparative analysis of human chromosome 5”. Nature. 431 (7006): 268\u201374. Bibcode:2004Natur.431..268S. doi:10.1038\/nature02919. PMID\u00a015372022.Prenzel KL, Warnecke-Eberz U, Xi H,  et\u00a0al. (2006). “Significant overexpression of SPARC\/osteonectin mRNA in pancreatic cancer compared to cancer of the papilla of Vater”. Oncol. Rep. 15 (5): 1397\u2013401. doi:10.3892\/or.15.5.1397. PMID\u00a016596217.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/spock1-wikipedia\/#breadcrumbitem","name":"SPOCK1 – Wikipedia"}}]}]