[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/sterol-c5-desaturase-like-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/sterol-c5-desaturase-like-wikipedia\/","headline":"Sterol-C5-desaturase-like – Wikipedia","name":"Sterol-C5-desaturase-like – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Lathosterol oxidase is a \u03947-sterol 5(6)-desaturase","datePublished":"2017-08-25","dateModified":"2017-08-25","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/sterol-c5-desaturase-like-wikipedia\/","wordCount":3567,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensLathosterol oxidase is a \u03947-sterol 5(6)-desaturase enzyme that in humans is encoded by the SC5D gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4This gene encodes an enzyme of cholesterol biosynthesis. The encoded protein catalyzes the conversion of lathosterol into 7-dehydrocholesterol. Mutations in this gene have been associated with lathosterolosis. Alternatively spliced transcript variants encoding the same protein have been described.[6]References[edit]Further reading[edit]Shefer S, Salen G, Batta AK,  et\u00a0al. (1995). “Markedly inhibited 7-dehydrocholesterol-delta 7-reductase activity in liver microsomes from Smith-Lemli-Opitz homozygotes”. J. Clin. Invest. 96 (4): 1779\u201385. doi:10.1172\/JCI118223. PMC\u00a0185814. PMID\u00a07560069.Ves-Losada A, Brenner RR (1995). “Fatty acid delta 5 desaturation in rat liver cell nuclei”. Mol. Cell. Biochem. 142 (2): 163\u201370. doi:10.1007\/BF00928937. PMID\u00a07770068. S2CID\u00a043739588.Takakuwa Y, Nishino H, Ishibe Y, Ishibashi T (1994). “Properties and kinetics of membrane-bound enzymes when both the enzyme and substrate are components of the same microsomal membrane. Studies on lathosterol 5-desaturase”. J. Biol. Chem. 269 (45): 27889\u201393. doi:10.1016\/S0021-9258(18)46870-6. PMID\u00a07961720.Maruyama K, Sugano S (1994). “Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides”. Gene. 138 (1\u20132): 171\u20134. doi:10.1016\/0378-1119(94)90802-8. PMID\u00a08125298.Poisson JP, Dupuy RP, Sarda P,  et\u00a0al. (1993). “Evidence that liver microsomes of human neonates desaturate essential fatty acids”. Biochim. Biophys. Acta. 1167 (2): 109\u201313. doi:10.1016\/0005-2760(93)90149-4. PMID\u00a08466936.Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K,  et\u00a0al. (1997). “Construction and characterization of a full length-enriched and a 5′-end-enriched cDNA library”. Gene. 200 (1\u20132): 149\u201356. doi:10.1016\/S0378-1119(97)00411-3. PMID\u00a09373149.Husselstein T, Schaller H, Gachotte D, Benveniste P (1999). “Delta7-sterol-C5-desaturase: molecular characterization and functional expression of wild-type and mutant alleles”. Plant Mol. Biol. 39 (5): 891\u2013906. doi:10.1023\/A:1006113919172. PMID\u00a010344195. S2CID\u00a05643392.Cho HP, Nakamura M, Clarke SD (2000). “Cloning, expression, and fatty acid regulation of the human delta-5 desaturase”. J. Biol. Chem. 274 (52): 37335\u20139. doi:10.1074\/jbc.274.52.37335. PMID\u00a010601301.Leonard AE, Kelder B, Bobik EG,  et\u00a0al. (2000). “cDNA cloning and characterization of human Delta5-desaturase involved in the biosynthesis of arachidonic acid”. Biochem. J. 347 Pt 3 (3): 719\u201324. doi:10.1042\/0264-6021:3470719. PMC\u00a01221008. PMID\u00a010769175.Nishi S, Nishino H, Ishibashi T (2000). “cDNA cloning of the mammalian sterol C5-desaturase and the expression in yeast mutant”. Biochim. Biophys. Acta. 1490 (1\u20132): 106\u20138. doi:10.1016\/s0167-4781(99)00248-1. PMID\u00a010786622.Sugawara T, Fujimoto Y, Ishibashi T (2001). “Molecular cloning and structural analysis of human sterol C5 desaturase”. Biochim. Biophys. Acta. 1533 (3): 277\u201384. doi:10.1016\/s1388-1981(01)00160-3. PMID\u00a011731337.Brunetti-Pierri N, Corso G, Rossi M,  et\u00a0al. (2002). “Lathosterolosis, a novel multiple-malformation\/mental retardation syndrome due to deficiency of 3beta-hydroxysteroid-delta5-desaturase”. Am. J. Hum. Genet. 71 (4): 952\u20138. doi:10.1086\/342668. PMC\u00a0378549. PMID\u00a012189593.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Krakowiak PA, Wassif CA, Kratz L,  et\u00a0al. (2004). “Lathosterolosis: an inborn error of human and murine cholesterol synthesis due to lathosterol 5-desaturase deficiency”. Hum. Mol. Genet. 12 (13): 1631\u201341. doi:10.1093\/hmg\/ddg172. PMID\u00a012812989.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/sterol-c5-desaturase-like-wikipedia\/#breadcrumbitem","name":"Sterol-C5-desaturase-like – Wikipedia"}}]}]