[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/stk10-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/stk10-wikipedia\/","headline":"STK10 – Wikipedia","name":"STK10 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Serine\/threonine-protein kinase 10 is an enzyme that in","datePublished":"2017-09-11","dateModified":"2017-09-11","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/0\/05\/PDB_2j7t_EBI.png\/180px-PDB_2j7t_EBI.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/0\/05\/PDB_2j7t_EBI.png\/180px-PDB_2j7t_EBI.png","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/stk10-wikipedia\/","wordCount":4833,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensSerine\/threonine-protein kinase 10 is an enzyme that in humans is encoded by the STK10 gene.[5][6]This gene encodes a member of the Ste20 family of serine\/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway.[6]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000072786 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000020272 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Kuramochi S, Matsuda Y, Okamoto M, Kitamura F, Yonekawa H, Karasuyama H (Jun 1999). “Molecular cloning of the human gene STK10 encoding lymphocyte-oriented kinase, and comparative chromosomal mapping of the human, mouse, and rat homologues”. Immunogenetics. 49 (5): 369\u201375. doi:10.1007\/s002510050509. PMID\u00a010199912. S2CID\u00a0877572.^ a b “Entrez Gene: STK10 serine\/threonine kinase 10”.Further reading[edit]ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}]]>Kuramochi S, Moriguchi T, Kuida K,  et\u00a0al. (1997). “LOK is a novel mouse STE20-like protein kinase that is expressed predominantly in lymphocytes”. J. Biol. Chem. 272 (36): 22679\u201384. doi:10.1074\/jbc.272.36.22679. PMID\u00a09278426.Tao L, Wadsworth S, Mercer J,  et\u00a0al. (2002). “Opposing roles of serine\/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells”. Biochem. J. 363 (Pt 1): 175\u201382. doi:10.1042\/0264-6021:3630175. PMC\u00a01222464. PMID\u00a011903060.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Walter SA, Cutler RE, Martinez R,  et\u00a0al. (2003). “Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue”. J. Biol. Chem. 278 (20): 18221\u20138. doi:10.1074\/jbc.M212556200. PMID\u00a012639966.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Beausoleil SA, Jedrychowski M, Schwartz D,  et\u00a0al. (2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130\u20135. Bibcode:2004PNAS..10112130B. doi:10.1073\/pnas.0404720101. PMC\u00a0514446. PMID\u00a015302935.Bignell G, Smith R, Hunter C,  et\u00a0al. (2006). “Sequence analysis of the protein kinase gene family in human testicular germ-cell tumors of adolescents and adults”. Genes Chromosomes Cancer. 45 (1): 42\u20136. doi:10.1002\/gcc.20265. PMC\u00a07212027. PMID\u00a016175573.Kimura K, Wakamatsu A, Suzuki Y,  et\u00a0al. (2006). “Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes”. Genome Res. 16 (1): 55\u201365. doi:10.1101\/gr.4039406. PMC\u00a01356129. PMID\u00a016344560.Beausoleil SA, Vill\u00e9n J, Gerber SA,  et\u00a0al. (2006). “A probability-based approach for high-throughput protein phosphorylation analysis and site localization”. Nat. Biotechnol. 24 (10): 1285\u201392. doi:10.1038\/nbt1240. PMID\u00a016964243. S2CID\u00a014294292.Wissing J, J\u00e4nsch L, Nimtz M,  et\u00a0al. (2007). “Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry”. Mol. Cell. Proteomics. 6 (3): 537\u201347. doi:10.1074\/mcp.T600062-MCP200. PMID\u00a017192257.li{counter-increment:listitem}.mw-parser-output .hlist ol>li::before{content:\" \"counter(listitem)\"a0 \"}.mw-parser-output .hlist dd ol>li:first-child::before,.mw-parser-output .hlist dt ol>li:first-child::before,.mw-parser-output .hlist li ol>li:first-child::before{content:\" (\"counter(listitem)\"a0 \"}]]>.navbox-abovebelow,.mw-parser-output tr+tr>.navbox-group,.mw-parser-output tr+tr>.navbox-image,.mw-parser-output tr+tr>.navbox-list{border-top:2px solid #fdfdfd}.mw-parser-output .navbox-title{background-color:#ccf}.mw-parser-output .navbox-abovebelow,.mw-parser-output .navbox-group,.mw-parser-output .navbox-subgroup .navbox-title{background-color:#ddf}.mw-parser-output .navbox-subgroup .navbox-group,.mw-parser-output .navbox-subgroup .navbox-abovebelow{background-color:#e6e6ff}.mw-parser-output .navbox-even{background-color:#f7f7f7}.mw-parser-output .navbox-odd{background-color:transparent}.mw-parser-output .navbox .hlist td dl,.mw-parser-output .navbox .hlist td ol,.mw-parser-output .navbox .hlist td ul,.mw-parser-output .navbox td.hlist dl,.mw-parser-output .navbox td.hlist ol,.mw-parser-output .navbox td.hlist ul{padding:0.125em 0}.mw-parser-output .navbox .navbar{display:block;font-size:100%}.mw-parser-output .navbox-title .navbar{float:left;text-align:left;margin-right:0.5em}]]>span,.mw-parser-output .navbar a>abbr{text-decoration:inherit}.mw-parser-output .navbar-mini abbr{font-variant:small-caps;border-bottom:none;text-decoration:none;cursor:inherit}.mw-parser-output .navbar-ct-full{font-size:114%;margin:0 7em}.mw-parser-output .navbar-ct-mini{font-size:114%;margin:0 4em}]]>PDB gallery2j7t: CRYSTAL STRUCTURE OF HUMAN SERINE THREONINE KINASE-10 BOUND TO SU11274Wikimedia ErrorOur servers are currently under maintenance or experiencing a technical problem.Please try again in a few\u00a0minutes.See the error message at the bottom of this page for more\u00a0information. 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