[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/strontium-89-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/strontium-89-wikipedia\/","headline":"Strontium-89 – Wikipedia","name":"Strontium-89 – Wikipedia","description":"From Wikipedia, the free encyclopedia Strontium-89 (89Sr) is a radioactive isotope of strontium produced by nuclear fission, with a half-life","datePublished":"2021-04-07","dateModified":"2021-04-07","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/4b\/Metastron_%28Strontium-89%29%2C_GE_Healthcare.jpg\/220px-Metastron_%28Strontium-89%29%2C_GE_Healthcare.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/4\/4b\/Metastron_%28Strontium-89%29%2C_GE_Healthcare.jpg\/220px-Metastron_%28Strontium-89%29%2C_GE_Healthcare.jpg","height":"331","width":"220"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/strontium-89-wikipedia\/","about":["Wiki"],"wordCount":2669,"articleBody":"From Wikipedia, the free encyclopediaStrontium-89 (89Sr) is a radioactive isotope of strontium produced by nuclear fission, with a half-life of 50.57 days. It undergoes \u03b2\u2212 decay into yttrium-89. Strontium-89 has an application in medicine.[2]Table of ContentsHistory[edit]Physiological effects and medical use[edit]See also[edit]References[edit]History[edit]Strontium-89 was first synthesized in 1937 by D. W. Stewart et al. at the University of Michigan; it was synthesized via irradiation of stable strontium (88Sr) with deuterons.[3] Biological properties and applications of strontium-89 were studied for the first time by Belgian scientist Charles Pecher.[4][5] Pecher filed a patent in May 1941 for the synthesis of strontium-89 and yttrium-86 using cyclotrons, and described the therapeutic use of strontium.[6]Physiological effects and medical use[edit]  Metastron, a preparation of strontium-89 chloride made by GE Healthcare and used for purposes such as prostate cancer treatment.[7]Strontium belongs to the same periodic family as calcium (alkaline earth metals), and is metabolised in a similar fashion, preferentially targeting metabolically active regions of the bone.  89Sr is an artificial radioisotope used in the treatment of osseous (bony) metastases of bone cancer.[8][9]In circumstances where cancer patients have widespread and painful bony metastases, the administration of 89Sr results in the delivery of beta particles directly to the area of bony problem, where calcium turnover is greatest.[10] Consequently, intravenous or intracavity administration of 89Sr may be helpful in the palliation of painful bony metastases, as it allows radiation to be targeted at metastatic lesions, inducing apoptosis of cells, membrane and protein damage. Subsequently, bone pain resulting from cytokine release at the site of lesions, bone-associated nerve compression and stretching of the periosteum may be reduced. Treatment with 89Sr has been particularly effective in patients with hormonally-resistant prostate cancer, often leading to a decreased requirement for opioid analgesics, an increase in time until further radiation is needed, and a decrease in tumour markers.See also[edit]References[edit]^ Delacroix, D.; Guerre, J. P.; Leblanc, P.; Hickman, C. (1 January 2002). “Radionuclide and Radiation Protection Data Handbook 2002”. Radiation Protection Dosimetry. 98 (1): 79. doi:10.1093\/oxfordjournals.rpd.a006705. PMID\u00a011916063.^ Audi, Georges; Wapstra, Aaldert Hendrik; Thibault, Catherne; Blachot, Jean; Bersillon, Olivier (2003). “The NUBASE evaluation of nuclear and decay properties” (PDF). Nuclear Physics A. 729 (1): 3\u2013128. Bibcode:2003NuPhA.729….3A. CiteSeerX\u00a010.1.1.692.8504. doi:10.1016\/j.nuclphysa.2003.11.001. Archived from the original (PDF) on 2011-07-20.^ Parker, A. M.; Thoennessen, M. (2012). “Discovery of rubidium, strontium, molybdenum, and rhodium isotopes”. Atomic Data and Nuclear Data Tables. 98 (4): 812\u2013831. arXiv:1102.2388. doi:10.1016\/j.adt.2012.06.001.^ Pecher, Charles (1941). “Biological Investigations with Radioactive Calcium and Strontium”. Proceedings of the Society for Experimental Biology and Medicine. 46 (1): 86\u201391. doi:10.3181\/00379727-46-11899. ISSN\u00a00037-9727. S2CID\u00a088173163.^ Pecher, Charles (1942). Biological investigations with radioactive calcium and strontium; preliminary report on the use of radioactive strontium in the treatment of metastatic bone cancer. Vol.\u00a02. University of California Publications in Pharmacology. pp.\u00a0117\u2013150. OCLC\u00a07837554.^ US 2302470, Pecher, Charles, “Material and method for radiography”, published 1941-05-14\u00a0^ “Strontium 89 (Metastron) treatment”. QEH Birmingham. NHS. Retrieved 23 November 2015.^ Halperin, Edward C.; Perez, Carlos A.; Brady, Luther W. (2008). Perez and Brady’s principles and practice of radiation oncology. Lippincott Williams & Wilkins. pp.\u00a01997\u2013. ISBN\u00a0978-0-7817-6369-1. Retrieved 19 July 2011.^ Bauman, Glenn; Charette, Manya; Reid, Robert; Sathya, Jinka (2005). “Radiopharmaceuticals for the palliation of painful bone metastases\u2014a systematic review”. Radiotherapy and Oncology. 75 (3): 258.E1\u2013258.E13. doi:10.1016\/j.radonc.2005.03.003. ISSN\u00a00167-8140. PMID\u00a016299924.^ Mertens, W. C.; Filipczak, L. A.; Ben-Josef, E.; Davis, L. P.; Porter, A. T. (1998). “Systemic bone-seeking radionuclides for palliation of painful osseous metastases: current concepts”. CA: A Cancer Journal for Clinicians. 48 (6): 361\u2013374. doi:10.3322\/canjclin.48.6.361. ISSN\u00a00007-9235. PMID\u00a09838899.  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