[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/surfactant-protein-d-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/surfactant-protein-d-wikipedia\/","headline":"Surfactant protein D – Wikipedia","name":"Surfactant protein D – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens SFTPD Available structures PDB Ortholog search:","datePublished":"2017-05-05","dateModified":"2017-05-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/54\/Protein_SFTPD_PDB_1b08.png\/250px-Protein_SFTPD_PDB_1b08.png","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/5\/54\/Protein_SFTPD_PDB_1b08.png\/250px-Protein_SFTPD_PDB_1b08.png","height":"235","width":"250"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/surfactant-protein-d-wikipedia\/","wordCount":10675,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensSFTPDAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1B08, 1M7L, 1PW9, 1PWB, 2GGU, 2GGX, 2ORJ, 2ORK, 2OS9, 2RIA, 2RIB, 2RIC, 2RID, 2RIE, 3DBZ, 3G81, 3G83, 3G84, 3IKN, 3IKP, 3IKQ, 3IKR, 4E52, 4M17, 4M18       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4IdentifiersAliasesSFTPD, COLEC7, PSP-D, SFTP4, SP-D, surfactant protein DExternal IDsOMIM: 178635 MGI: 109515 HomoloGene: 2272 GeneCards: SFTPD WikidataSurfactant protein D, also known as SP-D, is a lung surfactant protein part of the collagenous family of proteins called collectin.[5] In humans, SP-D is encoded by the SFTPD gene[6][7] and is part of the innate immune system.[8][9] Each SP-D subunit is composed of an N-terminal domain, a collagenous region, a nucleating neck region, and a C-terminal lectin domain.[5][10] Three of these subunits assemble to form a homotrimer, which further assemble into a tetrameric complex.[5][10]Table of ContentsInteractions[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Interactions[edit]Surfactant protein D has been shown to interact with DMBT1,[11][12] and hemagglutinin of influenza A virus.[13]  Post-translational modification of SP-D i.e. S-nitrosylation switches its function.[14][15][16]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000133661 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021795 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b c Hoppe HJ, Barlow PN, Reid KB (May 1994). “A parallel three stranded alpha-helical bundle at the nucleation site of collagen triple-helix formation”. FEBS Letters. 344 (2\u20133): 191\u20135. doi:10.1016\/0014-5793(94)00383-1. PMID\u00a08187882. S2CID\u00a02920539.^ Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W,  et\u00a0al. (October 1991). “Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain”. Archives of Biochemistry and Biophysics. 290 (1): 116\u201326. doi:10.1016\/0003-9861(91)90597-C. PMID\u00a01898081.^ Lu J, Willis AC, Reid KB (June 1992). “Purification, characterization and cDNA cloning of human lung surfactant protein D”. The Biochemical Journal. 284. 284 (3): 795\u2013802. doi:10.1042\/bj2840795. PMC\u00a01132609. PMID\u00a01339284.^ “Entrez Gene: SFTPD surfactant, pulmonary-associated protein D”.^ Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME (May 2008). “Surfactant protein D alters allergic lung responses in mice and human subjects”. The Journal of Allergy and Clinical Immunology. 121 (5): 1140\u20131147.e2. doi:10.1016\/j.jaci.2008.02.011. PMC\u00a04145593. PMID\u00a018355911.^ a b ^ Tino MJ, Wright JR (April 1999). “Glycoprotein-340 binds surfactant protein-A (SP-A) and stimulates alveolar macrophage migration in an SP-A-independent manner”. American Journal of Respiratory Cell and Molecular Biology. 20 (4): 759\u201368. doi:10.1165\/ajrcmb.20.4.3439. PMID\u00a010101009. S2CID\u00a029437779.^ Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C,  et\u00a0al. (May 1997). “Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule”. The Journal of Biological Chemistry. 272 (21): 13743\u20139. doi:10.1074\/jbc.272.21.13743. PMID\u00a09153228.^ Goh BC, Rynkiewicz MJ, Cafarella TR, White MR, Hartshorn KL, Allen K,  et\u00a0al. (November 2013). “Molecular mechanisms of inhibition of influenza by surfactant protein D revealed by large-scale molecular dynamics simulation”. Biochemistry. 52 (47): 8527\u201338. doi:10.1021\/bi4010683. PMC\u00a03927399. PMID\u00a024224757.^ Guo CJ, Atochina-Vasserman EN, Abramova E, Foley JP, Zaman A, Crouch E,  et\u00a0al. (November 2008). “S-nitrosylation of surfactant protein-D controls inflammatory function”. PLOS Biology. 6 (11): e266. doi:10.1371\/journal.pbio.0060266. PMC\u00a02581630. PMID\u00a019007302.^ Atochina-Vasserman EN, Guo CJ, Abramova E, Golden TN, Sims M, James ML,  et\u00a0al. (July 2015). “Surfactant dysfunction and lung inflammation in the female mouse model of lymphangioleiomyomatosis”. American Journal of Respiratory Cell and Molecular Biology. 53 (1): 96\u2013104. doi:10.1165\/rcmb.2014-0224OC. PMC\u00a04566108. PMID\u00a025474372.^ Atochina-Vasserman EN, Winkler C, Abramova H, Schaumann F, Krug N, Gow AJ,  et\u00a0al. (April 2011). “Segmental allergen challenge alters multimeric structure and function of surfactant protein D in humans”. American Journal of Respiratory and Critical Care Medicine. 183 (7): 856\u201364. doi:10.1164\/rccm.201004-0654OC. PMC\u00a03086753. PMID\u00a021131470.Further reading[edit]Atochina-Vasserman EN, Beers MF, Kadire H, Tomer Y, Inch A, Scott P,  et\u00a0al. (December 2007). “Selective inhibition of inducible NO synthase activity in vivo reverses inflammatory abnormalities in surfactant protein D-deficient mice”. Journal of Immunology. 179 (12): 8090\u20137. doi:10.4049\/jimmunol.179.12.8090. PMC\u00a04009628. PMID\u00a018056350.Guo CJ, Atochina-Vasserman EN, Abramova E, Foley JP, Zaman A, Crouch E,  et\u00a0al. (November 2008). “S-nitrosylation of surfactant protein-D controls inflammatory function”. PLOS Biology. 6 (11): e266. doi:10.1371\/journal.pbio.0060266. PMC\u00a02581630. PMID\u00a019007302.Hansen S, Holmskov U (August 1998). “Structural aspects of collectins and receptors for collectins”. Immunobiology. 199 (2): 165\u201389. doi:10.1016\/s0171-2985(98)80025-9. PMID\u00a09777404.Lu J, Willis AC, Reid KB (June 1992). “Purification, characterization and cDNA cloning of human lung surfactant protein D”. The Biochemical Journal. 284. 284 ( Pt 3) (3): 795\u2013802. doi:10.1042\/bj2840795. PMC\u00a01132609. PMID\u00a01339284.Ogasawara Y, Kuroki Y, Akino T (October 1992). “Pulmonary surfactant protein D specifically binds to phosphatidylinositol”. The Journal of Biological Chemistry. 267 (29): 21244\u20139. doi:10.1016\/S0021-9258(19)36824-3. PMID\u00a01400434.Rust K, Grosso L, Zhang V, Chang D, Persson A, Longmore W,  et\u00a0al. (October 1991). “Human surfactant protein D: SP-D contains a C-type lectin carbohydrate recognition domain”. Archives of Biochemistry and Biophysics. 290 (1): 116\u201326. doi:10.1016\/0003-9861(91)90597-C. PMID\u00a01898081.Kuroki Y, Shiratori M, Ogasawara Y, Tsuzuki A, Akino T (November 1991). “Characterization of pulmonary surfactant protein D: its copurification with lipids”. Biochimica et Biophysica Acta (BBA) – Lipids and Lipid Metabolism. 1086 (2): 185\u201390. doi:10.1016\/0005-2760(91)90006-4. PMID\u00a01932100.Schaeffer E, Guillou F, Part D, Zakin MM (November 1993). “A different combination of transcription factors modulates the expression of the human transferrin promoter in liver and Sertoli cells”. The Journal of Biological Chemistry. 268 (31): 23399\u2013408. doi:10.1016\/S0021-9258(19)49476-3. PMID\u00a08226864.K\u00f6lble K, Lu J, Mole SE, Kaluz S, Reid KB (August 1993). “Assignment of the human pulmonary surfactant protein D gene (SFTP4) to 10q22-q23 close to the surfactant protein A gene cluster”. Genomics. 17 (2): 294\u20138. doi:10.1006\/geno.1993.1324. PMID\u00a08406480.Crouch, E.; Rust, K.; Veile, R.; Donis-Keller, H.; Grosso, L. (February 1993). “Genomic organization of human surfactant protein D (SP-D). SP-D is encoded on chromosome 10q22.2-23.1”. Journal of Biological Chemistry. 268 (4): 2976\u20132983. doi:10.1016\/S0021-9258(18)53869-2. PMID\u00a08428971.Bonaldo MF, Lennon G, Soares MB (September 1996). “Normalization and subtraction: two approaches to facilitate gene discovery”. Genome Research. 6 (9): 791\u2013806. doi:10.1101\/gr.6.9.791. PMID\u00a08889548.Holmskov U, Lawson P, Teisner B, Tornoe I, Willis AC, Morgan C,  et\u00a0al. (May 1997). “Isolation and characterization of a new member of the scavenger receptor superfamily, glycoprotein-340 (gp-340), as a lung surfactant protein-D binding molecule”. The Journal of Biological Chemistry. 272 (21): 13743\u20139. doi:10.1074\/jbc.272.21.13743. PMID\u00a09153228.Botas C, Poulain F, Akiyama J, Brown C, Allen L, Goerke J,  et\u00a0al. (September 1998). “Altered surfactant homeostasis and alveolar type II cell morphology in mice lacking surfactant protein D”. Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11869\u201374. Bibcode:1998PNAS…9511869B. doi:10.1073\/pnas.95.20.11869. PMC\u00a021732. PMID\u00a09751757.H\u00e5kansson K, Lim NK, Hoppe HJ, Reid KB (March 1999). “Crystal structure of the trimeric alpha-helical coiled-coil and the three lectin domains of human lung surfactant protein D”. Structure. 7 (3): 255\u201364. doi:10.1016\/S0969-2126(99)80036-7. PMID\u00a010368295.Holmskov U, Mollenhauer J, Madsen J, Vitved L, Gronlund J, Tornoe I,  et\u00a0al. (September 1999). “Cloning of gp-340, a putative opsonin receptor for lung surfactant protein D”. Proceedings of the National Academy of Sciences of the United States of America. 96 (19): 10794\u20139. Bibcode:1999PNAS…9610794H. doi:10.1073\/pnas.96.19.10794. PMC\u00a017962. PMID\u00a010485905.Lausen M, Lynch N, Schlosser A, Tornoe I, Saekmose SG, Teisner B,  et\u00a0al. (November 1999). “Microfibril-associated protein 4 is present in lung washings and binds to the collagen region of lung surfactant protein D”. The Journal of Biological Chemistry. 274 (45): 32234\u201340. doi:10.1074\/jbc.274.45.32234. PMID\u00a010542261.Madsen J, Kliem A, Tornoe I, Skjodt K, Koch C, Holmskov U (June 2000). “Localization of lung surfactant protein D on mucosal surfaces in human tissues”. Journal of Immunology. 164 (11): 5866\u201370. doi:10.4049\/jimmunol.164.11.5866. PMID\u00a010820266.Zhang L, Ikegami M, Crouch EC, Korfhagen TR, Whitsett JA (June 2001). “Activity of pulmonary surfactant protein-D (SP-D) in vivo is dependent on oligomeric structure”. The Journal of Biological Chemistry. 276 (22): 19214\u20139. doi:10.1074\/jbc.M010191200. PMID\u00a011278637.External links[edit]PDB gallery1b08: LUNG SURFACTANT PROTEIN D (SP-D) (FRAGMENT)1m7l: Solution Structure of the Coiled-Coil Trimerization Domain from Lung Surfactant Protein D1pw9: High resolution crystal structure of an active recombinant fragment of human lung surfactant protein D1pwb: High resolution crystal structure of an active recombinant fragment of human lung surfactant protein D with maltose2ggu: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with maltotriose2ggx: Crystal structure of the trimer neck and carbohydrate recognition domain of human surfactant protein D in complex with p-nitrophenyl maltoside2orj: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with N-acetyl mannosamine2ork: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with inositol-1-phosphate2os9: crystal structure of the trimeric neck and carbohydrate recognition domain of human surfactant protein D in complex with myoinositol       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/surfactant-protein-d-wikipedia\/#breadcrumbitem","name":"Surfactant protein D – Wikipedia"}}]}]