[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/tbc1d4-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/tbc1d4-wikipedia\/","headline":"TBC1D4 – Wikipedia","name":"TBC1D4 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens AS160 (Akt substrate of 160 kDa), which was","datePublished":"2017-02-26","dateModified":"2017-02-26","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/tbc1d4-wikipedia\/","about":["Wiki"],"wordCount":6935,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensAS160 (Akt substrate of 160 kDa), which was originally known as TBC1 domain family member 4 (TBC1D4),[5] is a Rab GTPase-activating protein that in humans is encoded by the TBC1D4 gene.[6][7][8][9]The 160 kD protein product was first discovered in a screen for novel substrates of the serine-threonine kinase Akt2, which phosphorylates AS160 at Thr-642 and Ser-588[5][10] after insulin stimulation.[11]Insulin stimulation of fat and muscle cells results in translocation of the glucose transporter GLUT4 to the plasma membrane, and this translocation process is dependent on phosphorylation of AS160.[12]  The role of AS160 in GLUT4 translocation is mediated by its GTPase activating domain and interactions with Rab proteins in vesicle formation, increasing GLUT4 translocation when its GTPase activity is inhibited by Akt phosphorylation. Specifically, this inhibition activates RAB2A, RAB8A, RAB10 and RAB14.[13]AS160 also contains a calmodulin-binding domain, and this domain mediates phosphorylation-independent glucose uptake in muscle cells.[14]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000136111 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000033083 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b Sakamoto K, Holman GD (2008). “Emerging role for AS160\/TBC1D4 and TBC1D1 in the regulation of GLUT4 traffic”. Am. J. Physiol. Endocrinol. Metab. 295 (1): E29\u201337. doi:10.1152\/ajpendo.90331.2008. PMC\u00a02493596. PMID\u00a018477703.^ Kurihara LJ, Semenova E, Miller W, Ingram RS, Guan XJ, Tilghman SM (Feb 2002). “Candidate genes required for embryonic development: a comparative analysis of distal mouse chromosome 14 and human chromosome 13q22”. Genomics. 79 (2): 154\u201361. CiteSeerX\u00a010.1.1.16.1099. doi:10.1006\/geno.2002.6692. PMID\u00a011829485.^ Kane S, Sano H, Liu SC, Asara JM, Lane WS, Garner CC, Lienhard GE (Jun 2002). “A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain”. The Journal of Biological Chemistry. 277 (25): 22115\u20138. doi:10.1074\/jbc.C200198200. PMID\u00a011994271.^ Matsumoto Y, Imai Y, Lu Yoshida N, Sugita Y, Tanaka T, Tsujimoto G, Saito H, Oshida T (Aug 2004). “Upregulation of the transcript level of GTPase activating protein KIAA0603 in T cells from patients with atopic dermatitis”. FEBS Letters. 572 (1\u20133): 135\u201340. doi:10.1016\/j.febslet.2004.07.023. PMID\u00a015304337.^ “Entrez Gene: TBC1D4 TBC1 domain family, member 4”.^ Sano H, Kane S, Sano E, M\u00eeinea CP, Asara JM, Lane WS, Garner CW, Lienhard GE (Apr 2003). “Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation”. The Journal of Biological Chemistry. 278 (17): 14599\u2013602. doi:10.1074\/jbc.C300063200. PMID\u00a012637568.^ Kane S, Sano H, Liu SC, Asara JM, Lane WS, Garner CC, Lienhard GE (Jun 2002). “A method to identify serine kinase substrates. Akt phosphorylates a novel adipocyte protein with a Rab GTPase-activating protein (GAP) domain”. The Journal of Biological Chemistry. 277 (25): 22115\u20138. doi:10.1074\/jbc.C200198200. PMID\u00a011994271.^ Sano H, Kane S, Sano E, M\u00eeinea CP, Asara JM, Lane WS, Garner CW, Lienhard GE (Apr 2003). “Insulin-stimulated phosphorylation of a Rab GTPase-activating protein regulates GLUT4 translocation”. The Journal of Biological Chemistry. 278 (17): 14599\u2013602. doi:10.1074\/jbc.C300063200. PMID\u00a012637568.^ M\u00eeinea CP, Sano H, Kane S, Sano E, Fukuda M, Per\u00e4nen J, Lane WS, Lienhard GE (Oct 2005). “AS160, the Akt substrate regulating GLUT4 translocation, has a functional Rab GTPase-activating protein domain”. The Biochemical Journal. 391 (Pt 1): 87\u201393. doi:10.1042\/BJ20050887. PMC\u00a01237142. PMID\u00a015971998.^ Kramer HF, Taylor EB, Witczak CA, Fujii N, Hirshman MF, Goodyear LJ (Dec 2007). “Calmodulin-binding domain of AS160 regulates contraction- but not insulin-stimulated glucose uptake in skeletal muscle”. Diabetes. 56 (12): 2854\u201362. doi:10.2337\/db07-0681. PMID\u00a017717281.Further reading[edit]Chen S, Wasserman DH, MacKintosh C, Sakamoto K (2011). “Mice with AS160\/TBC1D4-Thr649Ala knockin mutation are glucose intolerant with reduced insulin sensitivity and altered GLUT4 trafficking”. Cell Metabolism. 13 (1): 68\u201379. doi:10.1016\/j.cmet.2010.12.005. PMC\u00a03081066. PMID\u00a021195350.Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Feb 1998). “Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro”. DNA Research. 5 (1): 31\u20139. doi:10.1093\/dnares\/5.1.31. PMID\u00a09628581.Nakayama M, Kikuno R, Ohara O (Nov 2002). “Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs”. Genome Research. 12 (11): 1773\u201384. doi:10.1101\/gr.406902. PMC\u00a0187542. PMID\u00a012421765.Lee SY, Obata Y, Yoshida M, Stockert E, Williamson B, Jungbluth AA, Chen YT, Old LJ, Scanlan MJ (Mar 2003). “Immunomic analysis of human sarcoma”. Proceedings of the National Academy of Sciences of the United States of America. 100 (5): 2651\u20136. Bibcode:2003PNAS..100.2651L. doi:10.1073\/pnas.0437972100. PMC\u00a0151395. PMID\u00a012601173.Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Vill\u00e9n J, Li J, Cohn MA, Cantley LC, Gygi SP (Aug 2004). “Large-scale characterization of HeLa cell nuclear phosphoproteins”. Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130\u20135. Bibcode:2004PNAS..10112130B. doi:10.1073\/pnas.0404720101. PMC\u00a0514446. PMID\u00a015302935.Jin J, Smith FD, Stark C, Wells CD, Fawcett JP, Kulkarni S, Metalnikov P, O’Donnell P, Taylor P, Taylor L, Zougman A, Woodgett JR, Langeberg LK, Scott JD, Pawson T (Aug 2004). “Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization”. Current Biology. 14 (16): 1436\u201350. doi:10.1016\/j.cub.2004.07.051. PMID\u00a015324660.Karlsson HK, Zierath JR, Kane S, Krook A, Lienhard GE, Wallberg-Henriksson H (Jun 2005). “Insulin-stimulated phosphorylation of the Akt substrate AS160 is impaired in skeletal muscle of type 2 diabetic subjects”. Diabetes. 54 (6): 1692\u20137. doi:10.2337\/diabetes.54.6.1692. PMID\u00a015919790.Kim JE, Tannenbaum SR, White FM (2005). “Global phosphoproteome of HT-29 human colon adenocarcinoma cells”. Journal of Proteome Research. 4 (4): 1339\u201346. doi:10.1021\/pr050048h. PMID\u00a016083285.Beausoleil SA, Vill\u00e9n J, Gerber SA, Rush J, Gygi SP (Oct 2006). “A probability-based approach for high-throughput protein phosphorylation analysis and site localization”. Nature Biotechnology. 24 (10): 1285\u201392. doi:10.1038\/nbt1240. PMID\u00a016964243. S2CID\u00a014294292.Treebak JT, Birk JB, Rose AJ, Kiens B, Richter EA, Wojtaszewski JF (Mar 2007). “AS160 phosphorylation is associated with activation of alpha2beta2gamma1- but not alpha2beta2gamma3-AMPK trimeric complex in skeletal muscle during exercise in humans”. American Journal of Physiology. Endocrinology and Metabolism. 292 (3): E715\u201322. doi:10.1152\/ajpendo.00380.2006. PMID\u00a017077344.Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (Nov 2006). “Global, in vivo, and site-specific phosphorylation dynamics in signaling networks”. Cell. 127 (3): 635\u201348. doi:10.1016\/j.cell.2006.09.026. PMID\u00a017081983.Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O’Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D (2007). “Large-scale mapping of human protein-protein interactions by mass spectrometry”. Molecular Systems Biology. 3 (1): 89. doi:10.1038\/msb4100134. PMC\u00a01847948. PMID\u00a017353931.Howlett KF, Sakamoto K, Garnham A, Cameron-Smith D, Hargreaves M (Jun 2007). “Resistance exercise and insulin regulate AS160 and interaction with 14-3-3 in human skeletal muscle”. Diabetes. 56 (6): 1608\u201314. doi:10.2337\/db06-1398. PMID\u00a017369524.Fr\u00f8sig C, Rose AJ, Treebak JT, Kiens B, Richter EA, Wojtaszewski JF (Aug 2007). “Effects of endurance exercise training on insulin signaling in human skeletal muscle: interactions at the level of phosphatidylinositol 3-kinase, Akt, and AS160”. Diabetes. 56 (8): 2093\u2013102. doi:10.2337\/db06-1698. PMID\u00a017513702.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/tbc1d4-wikipedia\/#breadcrumbitem","name":"TBC1D4 – Wikipedia"}}]}]