[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/tnfrsf12a-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/tnfrsf12a-wikipedia\/","headline":"TNFRSF12A – Wikipedia","name":"TNFRSF12A – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Tumor necrosis factor receptor superfamily member 12A also","datePublished":"2022-07-13","dateModified":"2022-07-13","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/tnfrsf12a-wikipedia\/","about":["Wiki"],"wordCount":5622,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensTumor necrosis factor receptor superfamily member 12A also known as the TWEAK receptor (TWEAKR) is a protein that in humans is encoded by the TNFRSF12A gene.[5][6][7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000006327 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000023905 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ ^ Meighan-Mantha RL, Hsu DK, Guo Y, Brown SA, Feng SL, Peifley KA, Alberts GF, Copeland NG, Gilbert DJ, Jenkins NA, Richards CM, Winkles JA (Jan 2000). “The mitogen-inducible Fn14 gene encodes a type I transmembrane protein that modulates fibroblast adhesion and migration”. J Biol Chem. 274 (46): 33166\u201376. doi:10.1074\/jbc.274.46.33166. PMID\u00a010551889.^ “Entrez Gene: TNFRSF12A tumor necrosis factor receptor superfamily, member 12A”.Further reading[edit]Campbell S, Michaelson J, Burkly L, Putterman C (2006). “The role of TWEAK\/Fn14 in the pathogenesis of inflammation and systemic autoimmunity” (PDF). Front. Biosci. 9 (1\u20133): 2273\u20132284. doi:10.2741\/1395. PMID\u00a015353286. S2CID\u00a029249853. Archived from the original (PDF) on 2019-02-16.Wiley SR, Cassiano L, Lofton T,  et\u00a0al. (2001). “A novel TNF receptor family member binds TWEAK and is implicated in angiogenesis”. Immunity. 15 (5): 837\u201346. doi:10.1016\/S1074-7613(01)00232-1. PMID\u00a011728344.Harada N, Nakayama M, Nakano H,  et\u00a0al. (2003). “Pro-inflammatory effect of TWEAK\/Fn14 interaction on human umbilical vein endothelial cells”. Biochem. Biophys. Res. Commun. 299 (3): 488\u201393. doi:10.1016\/S0006-291X(02)02670-0. PMID\u00a012445828.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Nakayama M, Ishidoh K, Kojima Y,  et\u00a0al. (2003). “Fibroblast growth factor-inducible 14 mediates multiple pathways of TWEAK-induced cell death”. J. Immunol. 170 (1): 341\u20138. doi:10.4049\/jimmunol.170.1.341. PMID\u00a012496418.Tran NL, McDonough WS, Donohue PJ,  et\u00a0al. (2003). “The Human Fn14 Receptor Gene Is Up-Regulated in Migrating Glioma Cells in Vitro and Overexpressed in Advanced Glial Tumors”. Am. J. Pathol. 162 (4): 1313\u201321. doi:10.1016\/S0002-9440(10)63927-2. PMC\u00a01851233. PMID\u00a012651623.Tanabe K, Bonilla I, Winkles JA, Strittmatter SM (2003). “Fibroblast growth factor-inducible-14 is induced in axotomized neurons and promotes neurite outgrowth”. J. Neurosci. 23 (29): 9675\u201386. doi:10.1523\/JNEUROSCI.23-29-09675.2003. PMC\u00a06740475. PMID\u00a014573547.Jin L, Nakao A, Nakayama M,  et\u00a0al. (2004). “Induction of RANTES by TWEAK\/Fn14 interaction in human keratinocytes”. J. Invest. Dermatol. 122 (5): 1175\u20139. doi:10.1111\/j.0022-202X.2004.22419.x. PMID\u00a015140220.Gerhard DS, Wagner L, Feingold EA,  et\u00a0al. (2004). “The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)”. Genome Res. 14 (10B): 2121\u20137. doi:10.1101\/gr.2596504. PMC\u00a0528928. PMID\u00a015489334.Tran NL, McDonough WS, Savitch BA,  et\u00a0al. (2005). “The tumor necrosis factor-like weak inducer of apoptosis (TWEAK)-fibroblast growth factor-inducible 14 (Fn14) signaling system regulates glioma cell survival via NFkappaB pathway activation and BCL-XL\/BCL-W expression”. J. Biol. Chem. 280 (5): 3483\u201392. doi:10.1074\/jbc.M409906200. PMID\u00a015611130.Rual JF, Venkatesan K, Hao T,  et\u00a0al. (2005). “Towards a proteome-scale map of the human protein-protein interaction network”. Nature. 437 (7062): 1173\u20138. Bibcode:2005Natur.437.1173R. doi:10.1038\/nature04209. PMID\u00a016189514. S2CID\u00a04427026.Chac\u00f3n MR, Richart C, G\u00f3mez JM,  et\u00a0al. (2006). “Expression of TWEAK and its receptor Fn14 in human subcutaneous adipose tissue. Relationship with other inflammatory cytokines in obesity”. Cytokine. 33 (3): 129\u201337. doi:10.1016\/j.cyto.2005.12.005. PMID\u00a016503147.Brown SA, Hanscom HN, Vu H,  et\u00a0al. (2006). “TWEAK binding to the Fn14 cysteine-rich domain depends on charged residues located in both the A1 and D2 modules”. Biochem. J. 397 (2): 297\u2013304. doi:10.1042\/BJ20051362. PMC\u00a01513280. PMID\u00a016526941.Mu\u00f1oz-Garc\u00eda B, Mart\u00edn-Ventura JL, Mart\u00ednez E,  et\u00a0al. (2006). “Fn14 is upregulated in cytokine-stimulated vascular smooth muscle cells and is expressed in human carotid atherosclerotic plaques: modulation by atorvastatin”. Stroke. 37 (8): 2044\u201353. doi:10.1161\/01.STR.0000230648.00027.00. PMID\u00a016809572.Tran NL, McDonough WS, Savitch BA,  et\u00a0al. (2007). “Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome”. Cancer Res. 66 (19): 9535\u201342. doi:10.1158\/0008-5472.CAN-06-0418. PMID\u00a017018610.Girgenrath M, Weng S, Kostek CA,  et\u00a0al. (2007). “TWEAK, via its receptor Fn14, is a novel regulator of mesenchymal progenitor cells and skeletal muscle regeneration”. EMBO J. 25 (24): 5826\u201339. doi:10.1038\/sj.emboj.7601441. PMC\u00a01698888. PMID\u00a017124496.Dogra C, Hall SL, Wedhas N,  et\u00a0al. (2007). “Fibroblast growth factor inducible 14 (Fn14) is required for the expression of myogenic regulatory factors and differentiation of myoblasts into myotubes. Evidence for TWEAK-independent functions of Fn14 during myogenesis”. J. Biol. Chem. 282 (20): 15000\u201310. doi:10.1074\/jbc.M608668200. PMC\u00a04149055. PMID\u00a017383968.This article incorporates text from the United States National Library of Medicine, which is in the public domain.ChemokineCSFInterferonIFNAR (\u03b1\/\u03b2, I)Agonists: AlbinterferonInterferon alpha (interferon alfa, IFN-\u03b1)Interferon alfa (IFNA1, IFNA2, IFNA4, IFNA5, IFNA6, IFNA7, IFNA8, IFNA10, IFNA13, IFNA14, IFNA16, IFNA17, IFNA21)Interferon alfa 2aInterferon alfa 2bInterferon alfa n1Interferon alfacon-1Interferon alpha-n3Interferon beta (IFN-\u03b2) (IFNB1, IFNB3)Interferon beta 1aInterferon beta 1bInterferon kappa (IFN-\u03b5\/\u03ba\/\u03c4\/\u03b6, IFNK)Interferon omega (IFN-\u03c9, IFNW1)Peginterferon alfa-2aPeginterferon alfa-2bIFNGR (\u03b3, II)IFNLR (\u03bb, III)See IL-28R (IFNLR) here instead.InterleukinTGF\u03b2TNFOthers  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/tnfrsf12a-wikipedia\/#breadcrumbitem","name":"TNFRSF12A – Wikipedia"}}]}]