[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/tra2b-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/tra2b-wikipedia\/","headline":"TRA2B – Wikipedia","name":"TRA2B – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Transformer-2 protein homolog beta, also known","datePublished":"2017-03-02","dateModified":"2017-03-02","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/cb\/PDB_2cqc_EBI.jpg\/180px-PDB_2cqc_EBI.jpg","url":"https:\/\/upload.wikimedia.org\/wikipedia\/commons\/thumb\/c\/cb\/PDB_2cqc_EBI.jpg\/180px-PDB_2cqc_EBI.jpg","height":"135","width":"180"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/tra2b-wikipedia\/","about":["Wiki"],"wordCount":5694,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensTransformer-2 protein homolog beta, also known as TRA2B previously known as splicing factor, arginine\/serine-rich 10 (transformer 2 homolog, Drosophila) (SFRS10), is a protein that in humans is encoded by the TRA2B gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Interactions[edit]TRA2B has been shown to interact with RBMX.[7]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000136527 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000022858 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: SFRS10 splicing factor, arginine\/serine-rich 10 (transformer 2 homolog, Drosophila)”.^ Nayler O, Cap C, Stamm S (October 1998). “Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform”. Genomics. 53 (2): 191\u2013202. doi:10.1006\/geno.1998.5471. PMID\u00a09790768.^ Hofmann, Yvonne; Wirth Brunhilde (Aug 2002). “hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1”. Hum. Mol. Genet. 11 (17): 2037\u201349. doi:10.1093\/hmg\/11.17.2037. ISSN\u00a00964-6906. PMID\u00a012165565.Further reading[edit]Matsuo N, Ogawa S, Imai Y,  et\u00a0al. (1996). “Cloning of a novel RNA binding polypeptide (RA301) induced by hypoxia\/reoxygenation”. J. Biol. Chem. 270 (47): 28216\u201322. doi:10.1074\/jbc.270.47.28216. PMID\u00a07499316.Lennon G, Auffray C, Polymeropoulos M, Soares MB (1996). “The I.M.A.G.E. Consortium: an integrated molecular analysis of genomes and their expression”. Genomics. 33 (1): 151\u20132. doi:10.1006\/geno.1996.0177. PMID\u00a08617505.Beil B, Screaton G, Stamm S (1997). “Molecular cloning of htra2-beta-1 and htra2-beta-2, two human homologs of tra-2 generated by alternative splicing”. DNA Cell Biol. 16 (6): 679\u201390. doi:10.1089\/dna.1997.16.679. PMID\u00a09212162.Imai Y, Matsuo N, Ogawa S,  et\u00a0al. (1998). “Cloning of a gene, YT521, for a novel RNA splicing-related protein induced by hypoxia\/reoxygenation”. Brain Res. Mol. Brain Res. 53 (1\u20132): 33\u201340. doi:10.1016\/S0169-328X(97)00262-3. PMID\u00a09473574.Tacke R, Tohyama M, Ogawa S, Manley JL (1998). “Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing”. Cell. 93 (1): 139\u201348. doi:10.1016\/S0092-8674(00)81153-8. PMID\u00a09546399. S2CID\u00a015384749.Nayler O, Cap C, Stamm S (1998). “Human transformer-2-beta gene (SFRS10): complete nucleotide sequence, chromosomal localization, and generation of a tissue-specific isoform”. Genomics. 53 (2): 191\u2013202. doi:10.1006\/geno.1998.5471. PMID\u00a09790768.Eldridge AG, Li Y, Sharp PA, Blencowe BJ (1999). “The SRm160\/300 splicing coactivator is required for exon-enhancer function”. Proc. Natl. Acad. Sci. U.S.A. 96 (11): 6125\u201330. Bibcode:1999PNAS…96.6125E. doi:10.1073\/pnas.96.11.6125. PMC\u00a026846. PMID\u00a010339552.Lai MC, Lin RI, Huang SY,  et\u00a0al. (2000). “A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins”. J. Biol. Chem. 275 (11): 7950\u20137. doi:10.1074\/jbc.275.11.7950. PMID\u00a010713112.Venables JP, Elliott DJ, Makarova OV,  et\u00a0al. (2000). “RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing”. Hum. Mol. Genet. 9 (5): 685\u201394. doi:10.1093\/hmg\/9.5.685. PMID\u00a010749975.Helmken C, Wirth B (2001). “Exclusion of Htra2-beta1, an up-regulator of full-length SMN2 transcript, as a modifying gene for spinal muscular atrophy”. Hum. Genet. 107 (6): 554\u20138. doi:10.1007\/s004390000409. PMID\u00a011153908. S2CID\u00a030528707.Young PJ, DiDonato CJ, Hu D,  et\u00a0al. (2002). “SRp30c-dependent stimulation of survival motor neuron (SMN) exon 7 inclusion is facilitated by a direct interaction with hTra2 beta 1”. Hum. Mol. Genet. 11 (5): 577\u201387. doi:10.1093\/hmg\/11.5.577. PMID\u00a011875052.Hofmann Y, Wirth B (2003). “hnRNP-G promotes exon 7 inclusion of survival motor neuron (SMN) via direct interaction with Htra2-beta1”. Hum. Mol. Genet. 11 (17): 2037\u201349. doi:10.1093\/hmg\/11.17.2037. PMID\u00a012165565.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Tran Q, Coleman TP, Roesser JR (2003). “Human transformer 2beta and SRp55 interact with a calcitonin-specific splice enhancer”. Biochim. Biophys. Acta. 1625 (2): 141\u201352. doi:10.1016\/S0167-4781(02)00600-0. PMID\u00a012531473.El Yazidi-Belkoura I, Adriaenssens E, Doll\u00e9 L,  et\u00a0al. (2003). “Tumor necrosis factor receptor-associated death domain protein is involved in the neurotrophin receptor-mediated antiapoptotic activity of nerve growth factor in breast cancer cells”. J. Biol. Chem. 278 (19): 16952\u20136. doi:10.1074\/jbc.M300631200. PMID\u00a012604596.Jiang Z, Tang H, Havlioglu N,  et\u00a0al. (2003). “Mutations in tau gene exon 10 associated with FTDP-17 alter the activity of an exonic splicing enhancer to interact with Tra2 beta”. J. Biol. Chem. 278 (21): 18997\u20139007. doi:10.1074\/jbc.M301800200. PMC\u00a02140226. PMID\u00a012649279.Chen X, Guo L, Lin W, Xu P (2004). “Expression of Tra2beta isoforms is developmentally regulated in a tissue- and temporal-specific pattern”. Cell Biol. Int. 27 (6): 491\u20136. doi:10.1016\/S1065-6995(03)00072-6. PMID\u00a012798777. S2CID\u00a044758770.Helmken C, Hofmann Y, Schoenen F,  et\u00a0al. (2004). “Evidence for a modifying pathway in SMA discordant families: reduced SMN level decreases the amount of its interacting partners and Htra2-beta1”. Hum. Genet. 114 (1): 11\u201321. doi:10.1007\/s00439-003-1025-2. PMID\u00a014520560. S2CID\u00a019872246.Li J, Hawkins IC, Harvey CD,  et\u00a0al. (2003). “Regulation of alternative splicing by SRrp86 and its interacting proteins”. Mol. Cell. Biol. 23 (21): 7437\u201347. doi:10.1128\/MCB.23.21.7437-7447.2003. PMC\u00a0207616. PMID\u00a014559993.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.PDB gallery2cqc: Solution Structure of the RNA recognition motif in Arginine\/serine-rich splicing factor 10       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/tra2b-wikipedia\/#breadcrumbitem","name":"TRA2B – Wikipedia"}}]}]