[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/transferrin-receptor-2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/transferrin-receptor-2-wikipedia\/","headline":"Transferrin receptor 2 – Wikipedia","name":"Transferrin receptor 2 – Wikipedia","description":"From Wikipedia, the free encyclopedia Transferrin receptor 2 (TfR2) is a protein that in humans is encoded by the TFR2","datePublished":"2014-01-05","dateModified":"2014-01-05","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/transferrin-receptor-2-wikipedia\/","about":["Wiki"],"wordCount":5130,"articleBody":"From Wikipedia, the free encyclopediaTransferrin receptor 2 (TfR2) is a protein that in humans is encoded by the TFR2 gene.[5][6] This protein is involved in the uptake of transferrin-bound iron into cells by endocytosis, although its role is minor compared to transferrin receptor 1.Table of ContentsFunction[edit]See also[edit]References[edit]Further reading[edit]External links[edit]Function[edit]This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized.[7]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000106327 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029716 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Glockner G, Scherer S, Schattevoy R, Boright A, Weber J, Tsui LC, Rosenthal A (Dec 1998). “Large-Scale Sequencing of Two Regions in Human Chromosome 7q22: Analysis of 650 kb of Genomic Sequence around the EPO and CUTL1 Loci Reveals 17 Genes”. Genome Res. 8 (10): 1060\u201373. doi:10.1101\/gr.8.10.1060. PMC\u00a0310788. PMID\u00a09799793.^ Mattman A, Huntsman D, Lockitch G, Langlois S, Buskard N, Ralston D, Butterfield Y, Rodrigues P, Jones S, Porto G, Marra M, De Sousa M, Vatcher G (Jul 2002). “Transferrin receptor 2 (TfR2) and HFE mutational analysis in non-C282Y iron overload: identification of a novel TfR2 mutation”. Blood. 100 (3): 1075\u20137. doi:10.1182\/blood-2002-01-0133. hdl:10400.16\/826. PMID\u00a012130528.^ “Entrez Gene: TFR2 transferrin receptor 2”.Further reading[edit]Subramaniam VN, Summerville L, Wallace DF (2003). “Molecular and cellular characterization of transferrin receptor 2”. Cell Biochem. Biophys. 36 (2\u20133): 235\u20139. doi:10.1385\/CBB:36:2-3:235. PMID\u00a012139409. S2CID\u00a0278321.Trinder D, Baker E (2003). “Transferrin receptor 2: a new molecule in iron metabolism”. Int. J. Biochem. Cell Biol. 35 (3): 292\u20136. doi:10.1016\/S1357-2725(02)00258-3. PMID\u00a012531241.Franchini M (2006). “Hereditary iron overload: update on pathophysiology, diagnosis, and treatment”. Am. J. Hematol. 81 (3): 202\u20139. doi:10.1002\/ajh.20493. PMID\u00a016493621. S2CID\u00a040950367.Deicher R, H\u00f6rl WH (2006). “New insights into the regulation of iron homeostasis”. Eur. J. Clin. Invest. 36 (5): 301\u20139. doi:10.1111\/j.1365-2362.2006.01633.x. PMID\u00a016634833. S2CID\u00a01726652.Feder JN, Penny DM, Irrinki A,  et\u00a0al. (1998). “The hemochromatosis gene product complexes with the transferrin receptor and lowers its affinity for ligand binding”. Proc. Natl. Acad. Sci. U.S.A. 95 (4): 1472\u20137. doi:10.1073\/pnas.95.4.1472. PMC\u00a019050. PMID\u00a09465039.Kawabata H, Yang R, Hirama T,  et\u00a0al. (1999). “Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family”. J. Biol. Chem. 274 (30): 20826\u201332. doi:10.1074\/jbc.274.30.20826. PMID\u00a010409623.Bennett MJ, Lebr\u00f3n JA, Bjorkman PJ (2000). “Crystal structure of the hereditary haemochromatosis protein HFE complexed with transferrin receptor”. Nature. 403 (6765): 46\u201353. doi:10.1038\/47417. PMID\u00a010638746. S2CID\u00a04427272.Kawabata H, Germain RS, Vuong PT,  et\u00a0al. (2000). “Transferrin receptor 2-alpha supports cell growth both in iron-chelated cultured cells and in vivo”. J. Biol. Chem. 275 (22): 16618\u201325. doi:10.1074\/jbc.M908846199. PMID\u00a010748106.Camaschella C, Roetto A, Cal\u00ec A,  et\u00a0al. (2000). “The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22”. Nat. Genet. 25 (1): 14\u20135. doi:10.1038\/75534. PMID\u00a010802645. S2CID\u00a09227077.West AP, Bennett MJ, Sellers VM,  et\u00a0al. (2001). “Comparison of the interactions of transferrin receptor and transferrin receptor 2 with transferrin and the hereditary hemochromatosis protein HFE” (PDF). J. Biol. Chem. 275 (49): 38135\u20138. doi:10.1074\/jbc.C000664200. PMID\u00a011027676. S2CID\u00a014295069.Roetto A, Totaro A, Piperno A,  et\u00a0al. (2001). “New mutations inactivating transferrin receptor 2 in hemochromatosis type 3”. Blood. 97 (9): 2555\u201360. doi:10.1182\/blood.V97.9.2555. PMID\u00a011313241. S2CID\u00a036015072.Kawabata H, Nakamaki T, Ikonomi P,  et\u00a0al. (2001). “Expression of transferrin receptor 2 in normal and neoplastic hematopoietic cells”. Blood. 98 (9): 2714\u20139. doi:10.1182\/blood.V98.9.2714. PMID\u00a011675342.Fleming RE, Ahmann JR, Migas MC,  et\u00a0al. (2002). “Targeted mutagenesis of the murine transferrin receptor-2 gene produces hemochromatosis”. Proc. Natl. Acad. Sci. U.S.A. 99 (16): 10653\u20138. doi:10.1073\/pnas.162360699. PMC\u00a0125003. PMID\u00a012134060.Hofmann WK, Tong XJ, Ajioka RS,  et\u00a0al. (2002). “Mutation analysis of transferrin-receptor 2 in patients with atypical hemochromatosis”. Blood. 100 (3): 1099\u2013100. doi:10.1182\/blood-2002-04-1077. PMID\u00a012150153.Deaglio S, Capobianco A, Cal\u00ec A,  et\u00a0al. (2003). “Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum”. Blood. 100 (10): 3782\u20139. doi:10.1182\/blood-2002-01-0076. PMID\u00a012393650.Vogt TM, Blackwell AD, Giannetti AM,  et\u00a0al. (2003). “Heterotypic interactions between transferrin receptor and transferrin receptor 2”. Blood. 101 (5): 2008\u201314. doi:10.1182\/blood-2002-09-2742. PMID\u00a012406888.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.External links[edit]  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/transferrin-receptor-2-wikipedia\/#breadcrumbitem","name":"Transferrin receptor 2 – Wikipedia"}}]}]