[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/tspy1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/tspy1-wikipedia\/","headline":"TSPY1 – Wikipedia","name":"TSPY1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in humans Testis-specific Y-encoded protein 1 is a protein that in humans is","datePublished":"2021-01-24","dateModified":"2021-01-24","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/tspy1-wikipedia\/","wordCount":3414,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in humansTestis-specific Y-encoded protein 1 is a protein that in humans is encoded by the TSPY1 gene.[3]The protein encoded by this gene is found only in testicular tissue and may be involved in spermatogenesis. Approximately 35 copies of this gene are present in humans, but only a single, nonfunctional orthologous gene is found in mice. Two transcript variants encoding different isoforms have been found for this gene.[4]  The protein is strongly overexpressed in gonadoblastoma.[5]See also[edit]References[edit]Further reading[edit]Chandley AC, Cooke HJ (1995). “Human male fertility–Y-linked genes and spermatogenesis”. Hum. Mol. Genet. 3. Spec No: 1449\u201352. doi:10.1093\/hmg\/3.suppl_1.1449. PMID\u00a07849736.Vogel T, Schmidtke J (1998). “Structure and function of TSPY, the Y-chromosome gene coding for the “testis-specific protein”“. Cytogenet. Cell Genet. 80 (1\u20134): 209\u201313. doi:10.1159\/000014982. PMID\u00a09678360. S2CID\u00a046875273.Lau YF (2000). “Gonadoblastoma, testicular and prostate cancers, and the TSPY gene”. Am. J. Hum. Genet. 64 (4): 921\u20137. doi:10.1086\/302353. PMC\u00a01377814. PMID\u00a010090875.Zhang JS, Yang-Feng TL, Muller U,  et\u00a0al. (1993). “Molecular isolation and characterization of an expressed gene from the human Y chromosome”. Hum. Mol. Genet. 1 (9): 717\u201326. doi:10.1093\/hmg\/1.9.717. PMID\u00a01284595.Arnemann J, Jakubiczka S, Th\u00fcring S, Schmidtke J (1992). “Cloning and sequence analysis of a human Y-chromosome-derived, testicular cDNA, TSPY”. Genomics. 11 (1): 108\u201314. doi:10.1016\/0888-7543(91)90107-P. PMID\u00a01765369.Arnemann J, Epplen JT, Cooke HJ,  et\u00a0al. (1988). “A human Y-chromosomal DNA sequence expressed in testicular tissue”. Nucleic Acids Res. 15 (21): 8713\u201324. doi:10.1093\/nar\/15.21.8713. PMC\u00a0306400. PMID\u00a03479749.Manz E, Schnieders F, Brechlin AM, Schmidtke J (1993). “TSPY-related sequences represent a microheterogeneous gene family organized as constitutive elements in DYZ5 tandem repeat units on the human Y chromosome”. Genomics. 17 (3): 726\u201331. doi:10.1006\/geno.1993.1393. PMID\u00a08244388.Kim HS, Takenaka O (1996). “A comparison of TSPY genes from Y-chromosomal DNA of the great apes and humans: sequence, evolution, and phylogeny”. Am. J. Phys. Anthropol. 100 (3): 301\u20139. doi:10.1002\/(SICI)1096-8644(199607)100:33.0.CO;2-X. PMID\u00a08798990.Vogt PH, Affara N, Davey P,  et\u00a0al. (1998). “Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997”. Cytogenet. Cell Genet. 79 (1\u20132): 1\u201320. doi:10.1159\/000134680. PMID\u00a09533010.Vogel T, Dittrich O, Mehraein Y,  et\u00a0al. (1998). “Murine and human TSPYL genes: novel members of the TSPY-SET-NAP1L1 family”. Cytogenet. Cell Genet. 81 (3\u20134): 265\u201370. doi:10.1159\/000015042. PMID\u00a09730615. S2CID\u00a046829106.Lau YF, Zhang J (2000). “Expression analysis of thirty one Y chromosome genes in human prostate cancer”. Mol. Carcinog. 27 (4): 308\u201321. doi:10.1002\/(SICI)1098-2744(200004)27:43.0.CO;2-R. PMID\u00a010747295. S2CID\u00a023677925.Ratti A, Stuppia L, Gatta V,  et\u00a0al. (2000). “Characterization of a new TSPY gene family member in Yq (TSPYq1)”. Cytogenet. Cell Genet. 88 (1\u20132): 159\u201362. doi:10.1159\/000015510. PMID\u00a010773691. S2CID\u00a020806022.Dechend F, Williams G, Skawran B,  et\u00a0al. (2001). “TSPY variants in six loci on the human Y chromosome”. Cytogenet. Cell Genet. 91 (1\u20134): 67\u201371. doi:10.1159\/000056821. PMID\u00a011173833. S2CID\u00a021757455.Lau Y, Chou P, Iezzoni J,  et\u00a0al. (2001). “Expression of a candidate gene for the gonadoblastoma locus in gonadoblastoma and testicular seminoma”. Cytogenet. Cell Genet. 91 (1\u20134): 160\u20134. doi:10.1159\/000056838. PMID\u00a011173850. S2CID\u00a034017469.Strausberg RL, Feingold EA, Grouse LH,  et\u00a0al. (2003). “Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences”. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899\u2013903. Bibcode:2002PNAS…9916899M. doi:10.1073\/pnas.242603899. PMC\u00a0139241. PMID\u00a012477932.Krick R, Jakubiczka S, Arnemann J (2003). “Expression, alternative splicing and haplotype analysis of transcribed testis specific protein (TSPY) genes”. Gene. 302 (1\u20132): 11\u20139. doi:10.1016\/S0378-1119(02)01104-6. PMID\u00a012527192.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/tspy1-wikipedia\/#breadcrumbitem","name":"TSPY1 – Wikipedia"}}]}]