[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/udp-n-acetylglucosamine-1-carboxyvinyltransferase-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/udp-n-acetylglucosamine-1-carboxyvinyltransferase-wikipedia\/","headline":"UDP-N-acetylglucosamine 1-carboxyvinyltransferase – Wikipedia","name":"UDP-N-acetylglucosamine 1-carboxyvinyltransferase – Wikipedia","description":"From Wikipedia, the free encyclopedia In enzymology, an UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) is an enzyme[1] that catalyzes the first committed","datePublished":"2018-09-17","dateModified":"2018-09-17","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","url":"https:\/\/wikimedia.org\/api\/rest_v1\/media\/math\/render\/svg\/1c37b981df851b9e54e489e017b1481e37d418f3","height":"","width":""},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/udp-n-acetylglucosamine-1-carboxyvinyltransferase-wikipedia\/","wordCount":1815,"articleBody":"From Wikipedia, the free encyclopediaIn enzymology, an UDP-N-acetylglucosamine 1-carboxyvinyltransferase (EC 2.5.1.7) is an enzyme[1] that catalyzes the first committed step in peptidoglycan biosynthesis of bacteria:phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine \u21cc{displaystyle rightleftharpoons } phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamineThus, the two substrates of this enzyme are phosphoenolpyruvate and UDP-N-acetyl-D-glucosamine, whereas its two products are phosphate and UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. The pyruvate moiety provides the linker that bridges the glycan and peptide portion of peptidoglycan.[2]The enzyme is inhibited by the antibiotic fosfomycin, which covalently modifies an active site cysteine residue.[3]This enzyme belongs to the family of transferases, specifically those transferring aryl or alkyl groups other than methyl groups. The systematic name of this enzyme class is phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase.[4]  This enzyme participates in amino sugars metabolism and glycan biosynthesis.Structural studies[edit]As of late 2007, 10 structures have been solved for this class of enzymes, with PDB accession codes 1A2N, 1DLG, 1EJC, 1EJD, 1EYN, 1NAW, 1Q3G, 1RYW, 1UAE, and 1YBG.References[edit]^ “Enolpyruvate transferase, EPT family”. Retrieved 2008-11-23.^ Brown ED, Vivas EI, Walsh CT, Kolter R (July 1995). “MurA (MurZ), the enzyme that catalyzes the first committed step in peptidoglycan biosynthesis, is essential in Escherichia coli”. J. Bacteriol. 177 (14): 4194\u20137. doi:10.1128\/jb.177.14.4194-4197.1995. PMC\u00a0177162. PMID\u00a07608103.^ King, Michael B. (2005). Lange Q & A. New York: McGraw-Hill, Medical Pub. Division. pp.\u00a0298. ISBN\u00a00-07-144578-1.^ Other names in common use include MurA transferase, UDP-N-acetylglucosamine 1-carboxyvinyl-transferase, UDP-N-acetylglucosamine enoylpyruvyltransferase, enoylpyruvate transferase, phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase, phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase, phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase, phosphoenolpyruvate:uridine-5′-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase, phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase, pyruvate-UDP-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetylglucosamine transferase, pyruvate-uridine diphospho-N-acetyl-glucosamine transferase, and pyruvic-uridine diphospho-N-acetylglucosaminyltransferase.Literature[edit]Gunetileke KG, Anwar RA (1968). “Biosynthesis of uridine diphospho-N-acetylmuramic acid. II Purification and properties of pyruvate-uridine diphospho-N-acetylglucosamine transferase and characterization of uridine diphospho-N-acetylenopyruvylglucosamine”. J. Biol. Chem. 243 (21): 5770\u20138. PMID\u00a05699062.Zemell RI, Anwar RA (1975). “Pyruvate-uridine diphospho-N-acetylglucosamine transferase Purification to homogeneity and feedback inhibition”. J. Biol. Chem. 250 (8): 3185\u201392. PMID\u00a01123336.van Heijenoort J (2001). “Recent advances in the formation of the bacterial peptidoglycan monomer unit”. Nat. Prod. Rep. 18 (5): 503\u201319. doi:10.1039\/a804532a. PMID\u00a011699883.  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