[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/vwa2-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/vwa2-wikipedia\/","headline":"VWA2 – Wikipedia","name":"VWA2 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein von Willebrand factor A domain-containing protein 2, also known as A domain-containing","datePublished":"2014-06-13","dateModified":"2014-06-13","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","height":"101","width":"135"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/vwa2-wikipedia\/","wordCount":2606,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Proteinvon Willebrand factor A domain-containing protein 2, also known as A domain-containing protein similar to matrilin and collagen (AMACO), is a protein that in humans is encoded by the VWA2 gene.[5][6]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4AMACO is a member of the von Willebrand factor A-like (VWA) domain containing protein superfamily and consists of three VWA-like domains, two EGF-like domains, a cysteine-rich domain and a unique C-terminal domain.[6]AMACO is an extracellular matrix protein and mostly deposited adjacent to basement membranes.[7]AMACO binds directly to FRAS1 which is part of the Fraser complex important for epithelial-connective tissue interaction,[8] the exact biological role of AMACO, however,  is still unknown. In 2005 AMACO was found markedly induced in colon cancers;[9] indicating that it might be a good candidate as a biomarker for this type of cancer.References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000165816 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000025082 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Entrez Gene: von Willebrand factor A domain containing 2”.^ a b Sengle G, Kobbe B, Morgelin M, Paulsson M, Wagener R (December 2003). “Identification and characterization of AMACO, a new member of the von Willebrand factor A-like domain protein superfamily with a regulated expression in the kidney”. The Journal of Biological Chemistry. 278 (50): 50240\u20139. doi:10.1074\/jbc.M307794200. PMID\u00a014506275.^ Gebauer JM, Keene DR, Olsen BR, Sorokin LM, Paulsson M, Wagener R (October 2009). “Mouse AMACO, a kidney and skin basement membrane associated molecule that mediates RGD-dependent cell attachment”. Matrix Biology. 28 (8): 456\u201362. doi:10.1016\/j.matbio.2009.07.006. PMID\u00a019651211.^ Richardson RJ, Gebauer JM, Zhang JL, Kobbe B, Keene DR, Karlsen KR, Richetti S, Wohl AP, Sengle G, Neiss WF, Paulsson M, Hammerschmidt M, Wagener R (May 2014). “AMACO is a component of the basement membrane-associated Fraser complex”. The Journal of Investigative Dermatology. 134 (5): 1313\u20131322. doi:10.1038\/jid.2013.492. PMC\u00a04361737. PMID\u00a024232570.^ Xin B, Platzer P, Fink SP, Reese L, Nosrati A, Willson JK, Wilson K, Markowitz S (January 2005). “Colon cancer secreted protein-2 (CCSP-2), a novel candidate serological marker of colon neoplasia”. Oncogene. 24 (4): 724\u201331. doi:10.1038\/sj.onc.1208134. PMID\u00a015580307.Further reading[edit]Eller E, Vardi P, Daly MJ, Babu S, Roberts C, Yang F, Eisenbarth GS, Fain PR (December 2004). “IDDM17: polymorphisms in the AMACO gene are associated with dominant protection against type 1A diabetes in a Bedouin Arab family”. Annals of the New York Academy of Sciences. 1037 (1): 145\u20139. Bibcode:2004NYASA1037..145E. doi:10.1196\/annals.1337.024. PMID\u00a015699509. S2CID\u00a041689175.Gebauer JM, M\u00fcller S, Hanisch FG, Paulsson M, Wagener R (June 2008). “O-glucosylation and O-fucosylation occur together in close proximity on the first epidermal growth factor repeat of AMACO (VWA2 protein)”. The Journal of Biological Chemistry. 283 (26): 17846\u201354. doi:10.1074\/jbc.M704820200. PMID\u00a018434322.External links[edit]Wikimedia Error       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Our servers are currently under maintenance or experiencing a technical problem.Please try again in a few\u00a0minutes.See the error message at the bottom of this page for more\u00a0information.      (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/vwa2-wikipedia\/#breadcrumbitem","name":"VWA2 – Wikipedia"}}]}]