[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/wipi1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/wipi1-wikipedia\/","headline":"WIPI1 – Wikipedia","name":"WIPI1 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens WD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also","datePublished":"2016-11-26","dateModified":"2016-11-26","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","url":"https:\/\/www.wikimedia.org\/static\/images\/wmf-logo.png","height":"101","width":"135"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/wipi1-wikipedia\/","wordCount":2861,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensWD repeat domain phosphoinositide-interacting protein 1 (WIPI-1), also known as Atg18 protein homolog (ATG18) and WD40 repeat protein interacting with phosphoinositides of 49 kDa (WIPI 49 kDa), is a protein that in humans is encoded by the WIPI1 gene.[5][6][7]Table of ContentsStructure and function[edit]See also[edit]References[edit]Further reading[edit]Structure and function[edit]WD40 repeat proteins are key components of many essential biologic functions. They regulate the assembly of multiprotein complexes by presenting a beta-propeller platform for simultaneous and reversible protein\u2013protein interactions. Members of the WIPI subfamily of WD40 repeat proteins, such as WIPI1, have a 7-bladed propeller structure and contain a conserved motif for interaction with phospholipids.[5][7]See also[edit]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000070540 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000041895 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ a b “Entrez Gene: WD repeat domain”.^ Jeffries TR, Dove SK, Michell RH, Parker PJ (June 2004). “PtdIns-specific MPR pathway association of a novel WD40 repeat protein, WIPI49”. Mol. Biol. Cell. 15 (6): 2652\u201363. doi:10.1091\/mbc.E03-10-0732. PMC\u00a0420090. PMID\u00a015020712.^ a b Proikas-Cezanne T, Waddell S, Gaugel A, Frickey T, Lupas A, Nordheim A (December 2004). “WIPI-1alpha (WIPI49), a member of the novel 7-bladed WIPI protein family, is aberrantly expressed in human cancer and is linked to starvation-induced autophagy”. Oncogene. 23 (58): 9314\u201325. doi:10.1038\/sj.onc.1208331. PMID\u00a015602573.Further reading[edit]ul{margin-left:0}.mw-parser-output .refbegin-hanging-indents>ul>li{margin-left:0;padding-left:3.2em;text-indent:-3.2em}.mw-parser-output .refbegin-hanging-indents ul,.mw-parser-output .refbegin-hanging-indents ul li{list-style:none}@media(max-width:720px){.mw-parser-output .refbegin-hanging-indents>ul>li{padding-left:1.6em;text-indent:-1.6em}}.mw-parser-output .refbegin-columns{margin-top:0.3em}.mw-parser-output .refbegin-columns ul{margin-top:0}.mw-parser-output .refbegin-columns li{page-break-inside:avoid;break-inside:avoid-column}]]>Chasman DI, Par\u00e9 G, Mora S, Hopewell JC, Peloso G, Clarke R, Cupples LA, Hamsten A, Kathiresan S, M\u00e4larstig A, Ordovas JM, Ripatti S, Parker AN, Miletich JP, Ridker PM (November 2009). “Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis”. PLOS Genet. 5 (11): e1000730. doi:10.1371\/journal.pgen.1000730. PMC\u00a02777390. PMID\u00a019936222.Behrends C, Sowa ME, Gygi SP, Harper JW (July 2010). “Network organization of the human autophagy system”. Nature. 466 (7302): 68\u201376. Bibcode:2010Natur.466…68B. doi:10.1038\/nature09204. PMC\u00a02901998. PMID\u00a020562859.Proikas-Cezanne T, Ruckerbauer S, Stierhof YD, Berg C, Nordheim A (July 2007). “Human WIPI-1 puncta-formation: a novel assay to assess mammalian autophagy”. FEBS Lett. 581 (18): 3396\u2013404. doi:10.1016\/j.febslet.2007.06.040. PMID\u00a017618624. S2CID\u00a023430881.This article incorporates text from the United States National Library of Medicine, which is in the public domain.Wikimedia ErrorOur servers are currently under maintenance or experiencing a technical problem.Please try again in a few\u00a0minutes.See the error message at the bottom of this page for more\u00a0information. 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