[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/wnk3-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/wnk3-wikipedia\/","headline":"WNK3 – Wikipedia","name":"WNK3 – Wikipedia","description":"From Wikipedia, the free encyclopedia Protein-coding gene in the species Homo sapiens Serine\/threonine-protein kinase WNK3, also known as protein kinase","datePublished":"2022-10-17","dateModified":"2022-10-17","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/wnk3-wikipedia\/","about":["Wiki"],"wordCount":4693,"articleBody":"From Wikipedia, the free encyclopediaProtein-coding gene in the species Homo sapiensSerine\/threonine-protein kinase WNK3, also known as protein kinase lysine-deficient 3, is a protein that in humans is encoded by the WNK3 gene.[5]Function[edit]WNK3 is a protein belonging to the ‘with no lysine’ family of serine-threonine protein kinases. These family members lack the catalytic lysine in subdomain II, and instead have a conserved lysine in subdomain I. This family member functions as a positive regulator of the transcellular Ca2+ transport pathway, and it plays a role in the increase of cell survival in a caspase 3 dependent pathway.[5]References[edit]Further reading[edit]Ross MT, Grafham DV, Coffey AJ,  et\u00a0al. (2005). “The DNA sequence of the human X chromosome”. Nature. 434 (7031): 325\u201337. Bibcode:2005Natur.434..325R. doi:10.1038\/nature03440. PMC\u00a02665286. PMID\u00a015772651.Nagase T, Kikuno R, Nakayama M,  et\u00a0al. (2000). “Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 7 (4): 273\u201381. doi:10.1093\/dnares\/7.4.271. PMID\u00a010997877.Yang CL, Zhu X, Ellison DH (2007). “The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex”. J. Clin. Invest. 117 (11): 3403\u201311. doi:10.1172\/JCI32033. PMC\u00a02045602. PMID\u00a017975670.Rinehart J, Kahle KT, de Los Heros P,  et\u00a0al. (2005). “WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl\u2212 cotransporters required for normal blood pressure homeostasis”. Proc. Natl. Acad. Sci. U.S.A. 102 (46): 16777\u201382. Bibcode:2005PNAS..10216777R. doi:10.1073\/pnas.0508303102. PMC\u00a01283841. PMID\u00a016275913.Ko B, Hoover RS (2009). “Molecular physiology of the thiazide-sensitive sodium-chloride cotransporter”. Curr. Opin. Nephrol. Hypertens. 18 (5): 421\u20137. doi:10.1097\/MNH.0b013e32832f2fcb. PMC\u00a02947818. PMID\u00a019636250.San-Cristobal P, Ponce-Coria J, V\u00e1zquez N,  et\u00a0al. (2008). “WNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl\u2212 cotransporter”. Am. J. Physiol. Renal Physiol. 295 (4): F1199-206. doi:10.1152\/ajprenal.90396.2008. PMC\u00a02576145. PMID\u00a018701621.Glover M, Zuber AM, O’Shaughnessy KM (2009). “Renal and brain isoforms of WNK3 have opposite effects on NCCT expression”. J. Am. Soc. Nephrol. 20 (6): 1314\u201322. doi:10.1681\/ASN.2008050542. PMC\u00a02689907. PMID\u00a019470686.Auffray C, Behar G, Bois F,  et\u00a0al. (1995). “[IMAGE: molecular integration of the analysis of the human genome and its expression]”. Comptes Rendus de l’Acad\u00e9mie des Sciences, S\u00e9rie III. 318 (2): 263\u201372. PMID\u00a07757816.Kahle KT, Ring AM, Lifton RP (2008). “Molecular physiology of the WNK kinases”. Annu. Rev. Physiol. 70: 329\u201355. doi:10.1146\/annurev.physiol.70.113006.100651. PMID\u00a017961084.Zhang W, Na T, Peng JB (2008). “WNK3 positively regulates epithelial calcium channels TRPV5 and TRPV6 via a kinase-dependent pathway”. Am. J. Physiol. Renal Physiol. 295 (5): F1472-84. doi:10.1152\/ajprenal.90229.2008. PMC\u00a02584897. PMID\u00a018768590.Ver\u00edssimo F, Silva E, Morris JD,  et\u00a0al. (2006). “Protein kinase WNK3 increases cell survival in a caspase-3-dependent pathway”. Oncogene. 25 (30): 4172\u201382. doi:10.1038\/sj.onc.1209449. PMID\u00a016501604.Moniz S, Jordan P (2010). “Emerging roles for WNK kinases in cancer”. Cell. Mol. Life Sci. 67 (8): 1265\u201376. doi:10.1007\/s00018-010-0261-6. PMID\u00a020094755. S2CID\u00a032790065.Talmud PJ, Drenos F, Shah S,  et\u00a0al. (2009). “Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip”. Am. J. Hum. Genet. 85 (5): 628\u201342. doi:10.1016\/j.ajhg.2009.10.014. PMC\u00a02775832. PMID\u00a019913121.Qiao Y, Liu X, Harvard C,  et\u00a0al. (2008). “Autism-associated familial microdeletion of Xp11.22”. Clin. Genet. 74 (2): 134\u201344. doi:10.1111\/j.1399-0004.2008.01028.x. PMID\u00a018498374. S2CID\u00a022008997.Wilson FH, Disse-Nicod\u00e8me S, Choate KA,  et\u00a0al. (2001). “Human hypertension caused by mutations in WNK kinases”. Science. 293 (5532): 1107\u201312. doi:10.1126\/science.1062844. PMID\u00a011498583. S2CID\u00a022700809.Heise CJ, Xu BE, Deaton SL,  et\u00a0al. (2010). “Serum and glucocorticoid-induced kinase (SGK) 1 and the epithelial sodium channel are regulated by multiple with no lysine (WNK) family members”. J. Biol. Chem. 285 (33): 25161\u20137. doi:10.1074\/jbc.M110.103432. PMC\u00a02919078. PMID\u00a020525693.Holden S, Cox J, Raymond FL (2004). “Cloning, genomic organization, alternative splicing and expression analysis of the human gene WNK3 (PRKWNK3)”. Gene. 335: 109\u201319. doi:10.1016\/j.gene.2004.03.009. PMID\u00a015194194.Ota T, Suzuki Y, Nishikawa T,  et\u00a0al. (2004). “Complete sequencing and characterization of 21,243 full-length human cDNAs”. Nat. Genet. 36 (1): 40\u20135. doi:10.1038\/ng1285. PMID\u00a014702039.Ver\u00edssimo F, Jordan P (2001). “WNK kinases, a novel protein kinase subfamily in multi-cellular organisms”. Oncogene. 20 (39): 5562\u20139. doi:10.1038\/sj.onc.1204726. PMID\u00a011571656.Bailey SD, Xie C, Do R,  et\u00a0al. (2010). “Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study”. Diabetes Care. 33 (10): 2250\u20133. doi:10.2337\/dc10-0452. PMC\u00a02945168. PMID\u00a020628086.This article incorporates text from the United States National Library of Medicine, which is in the public domain.  "},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/wnk3-wikipedia\/#breadcrumbitem","name":"WNK3 – Wikipedia"}}]}]