[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/wwc1-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/wwc1-wikipedia\/","headline":"WWC1 – Wikipedia","name":"WWC1 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Protein KIBRA also known as kidney","datePublished":"2018-09-22","dateModified":"2018-09-22","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/wwc1-wikipedia\/","about":["Wiki"],"wordCount":5814,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensProtein KIBRA also known as kidney and brain expressed protein (KIBRA) or WW domain-containing protein 1 (WWC1) is a protein that in humans is encoded by the WWC1 gene.[5][6][7]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsResearch on human memory[edit]Interactions[edit]References[edit]Further reading[edit]External links[edit]Research on human memory[edit]A single nucleotide polymorphism  (rs17070145) [8] in the gene has been associated with human memory performance in one 2006 study.[9] While no significant support for KIBRA’s association with memory was found in a 2008 study with 584 subjects,[10] the original 2006 study was replicated in a smaller sample of an elderly population in 2008.[11]  A subsequent study in 2009 in two large UK samples indicated that KIBRA is specifically associated with forgetting of non-semantic material.[12]Studies have also begun to investigate the role of KIBRA in Alzheimer’s disease.[13]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Interactions[edit]KIBRA has at least 10 interaction partners, including synaptopodin, PKC\u03b6 and  Dendrin, most of which modify synaptic plasticity.For instance, Dendrin is  a post-synaptic protein with expression regulated by sleep deprivation.[14]KIBRA has been shown to interact with Protein kinase M\u03b6.[15]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000113645 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000018849 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Nagase T, Ishikawa K, Suyama M, p Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (May 1999). “Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Res. 5 (6): 355\u201364. doi:10.1093\/dnares\/5.6.355. PMID\u00a010048485.^ Kremerskothen J, Plaas C, B\u00fcther K, Finger I, Veltel S, Matanis T, Liedtke T, Barnekow A (Jan 2003). “Characterization of KIBRA, a novel WW domain-containing protein”. Biochem Biophys Res Commun. 300 (4): 862\u20137. doi:10.1016\/S0006-291X(02)02945-5. PMID\u00a012559952.^ “Entrez Gene: WWC1 WW and C2 domain containing 1”.^ “dbSNP: rs17070145”.^ Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, H\u00e4nggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ (October 2006). “Common Kibra alleles are associated with human memory performance”. Science. 314 (5798): 475\u20138. Bibcode:2006Sci…314..475P. doi:10.1126\/science.1129837. PMID\u00a017053149. S2CID\u00a017727381.^ Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, M\u00f6ller HJ, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB (July 2008). “Failure to replicate effect of Kibra on human memory in two large cohorts of European origin”. American Journal of Medical Genetics. 147B (5): 667\u20138. doi:10.1002\/ajmg.b.30658. hdl:11858\/00-001M-0000-0012-C950-9. PMID\u00a018205171. S2CID\u00a011769730.^ Schaper K, Kolsch H, Popp J, Wagner M, Jessen F (July 2008). “KIBRA gene variants are associated with episodic memory in healthy elderly”. Neurobiol. Aging. 29 (7): 1123\u20135. doi:10.1016\/j.neurobiolaging.2007.02.001. PMID\u00a017353070. S2CID\u00a035149885.^ Bates TC, Price JF, Harris SE, Marioni RE, Fowkes FG, Stewart MC, Murray GD, Whalley LJ, Starr JM, Deary IJ (July 2009). “Association of KIBRA and memory”. Neurosci. Lett. 458 (3): 140\u20133. doi:10.1016\/j.neulet.2009.04.050. PMID\u00a019397951. S2CID\u00a0143816223.^ Corneveaux JJ, Liang WS, Reiman EM, Webster JA, Myers AJ, Zismann VL, Joshipura KD, Pearson JV, Hu-Lince D, Craig DW, Coon KD, Dunckley T, Bandy D, Lee W, Chen K, Beach TG, Mastroeni D, Grover A, Ravid R, Sando SB, Aasly JO, Heun R, Jessen F, K\u00f6lsch H, Rogers J, Hutton ML, Melquist S, Petersen RC, Alexander GE, Caselli RJ, Papassotiropoulos A, Stephan DA, Huentelman MJ (June 2010). “Evidence for an association between KIBRA and late-onset Alzheimer’s disease”. Neurobiol. Aging. 31 (6): 901\u20139. doi:10.1016\/j.neurobiolaging.2008.07.014. PMC\u00a02913703. PMID\u00a018789830.^ Schneider A, Huentelman MJ, Kremerskothen J, Duning K, Spoelgen R, Nikolich K (2010). “KIBRA: A New Gateway to Learning and Memory?”. Frontiers in Aging Neuroscience. 2: 4. doi:10.3389\/neuro.24.004.2010. PMC\u00a02874402. PMID\u00a020552044.^ B\u00fcther K, Plaas C, Barnekow A, Kremerskothen J (May 2004). “KIBRA is a novel substrate for protein kinase Czeta”. Biochem. Biophys. Res. Commun. 317 (3): 703\u20137. doi:10.1016\/j.bbrc.2004.03.107. PMID\u00a015081397.Further reading[edit]Need AC, Attix DK, McEvoy JM, Cirulli ET, Linney KN, Wagoner AP, Gumbs CE, Giegling I, M\u00f6ller HJ, Francks C, Muglia P, Roses A, Gibson G, Weale ME, Rujescu D, Goldstein DB (2008). “Failure to replicate effect of kibra on human memory in two large cohorts of European origin”. American Journal of Medical Genetics. 147B (5): 667\u20138. doi:10.1002\/ajmg.b.30658. hdl:11858\/00-001M-0000-0012-C950-9. PMID\u00a018205171. S2CID\u00a011769730.Almeida OP, Schwab SG, Lautenschlager NT, Morar B, Greenop KR, Flicker L, Wildenauer D (2008). “KIBRA Genetic Polymorphism Influences Episodic Memory in Later Life, but Does Not Increase the Risk of Mild Cognitive Impairment”. Journal of Cellular and Molecular Medicine. 12 (5A): 1672\u20136. doi:10.1111\/j.1582-4934.2008.00229.x. PMC\u00a03918083. PMID\u00a018194457.Hilton HN, Stanford PM, Harris J, Oakes SR, Kaplan W, Daly RJ, Ormandy CJ (2008). “KIBRA interacts with discoidin domain receptor 1 to modulate collagen-induced signalling”. Biochim. Biophys. Acta. 1783 (3): 383\u201393. doi:10.1016\/j.bbamcr.2007.12.007. PMID\u00a018190796.Rodr\u00edguez-Rodr\u00edguez E, Infante J, Llorca J, Mateo I, S\u00e1nchez-Quintana C, Garc\u00eda-Gorostiaga I, S\u00e1nchez-Juan P, Berciano J, Combarros O (2009). “Age-dependent association of KIBRA genetic variation and Alzheimer’s disease risk”. Neurobiol. Aging. 30 (2): 322\u20134. doi:10.1016\/j.neurobiolaging.2007.07.003. PMID\u00a017707552. S2CID\u00a028263842.Schaper K, Kolsch H, Popp J, Wagner M, Jessen F (2008). “KIBRA gene variants are associated with episodic memory in healthy elderly”. Neurobiol. Aging. 29 (7): 1123\u20135. doi:10.1016\/j.neurobiolaging.2007.02.001. PMID\u00a017353070. S2CID\u00a035149885.Papassotiropoulos A, Stephan DA, Huentelman MJ, Hoerndli FJ, Craig DW, Pearson JV, Huynh KD, Brunner F, Corneveaux J, Osborne D, Wollmer MA, Aerni A, Coluccia D, H\u00e4nggi J, Mondadori CR, Buchmann A, Reiman EM, Caselli RJ, Henke K, de Quervain DJ (2006). “Common Kibra alleles are associated with human memory performance”. Science. 314 (5798): 475\u20138. Bibcode:2006Sci…314..475P. doi:10.1126\/science.1129837. PMID\u00a017053149. S2CID\u00a017727381.Rayala SK, den Hollander P, Manavathi B, Talukder AH, Song C, Peng S, Barnekow A, Kremerskothen J, Kumar R (2006). “Essential role of KIBRA in co-activator function of dynein light chain 1 in mammalian cells”. J. Biol. Chem. 281 (28): 19092\u20139. doi:10.1074\/jbc.M600021200. PMID\u00a016684779.B\u00fcther K, Plaas C, Barnekow A, Kremerskothen J (2004). “KIBRA is a novel substrate for protein kinase Czeta”. Biochem. Biophys. Res. Commun. 317 (3): 703\u20137. doi:10.1016\/j.bbrc.2004.03.107. PMID\u00a015081397.External links[edit]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/wwc1-wikipedia\/#breadcrumbitem","name":"WWC1 – Wikipedia"}}]}]