[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/zcchc6-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki24\/zcchc6-wikipedia\/","headline":"ZCCHC6 – Wikipedia","name":"ZCCHC6 – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 Protein-coding gene in the species Homo sapiens Terminal uridylyltransferase 7 (TUT7), also known","datePublished":"2016-10-10","dateModified":"2016-10-10","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki24\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki24\/zcchc6-wikipedia\/","about":["Wiki"],"wordCount":3610,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Protein-coding gene in the species Homo sapiensTerminal uridylyltransferase 7 (TUT7), also known as “zinc finger, CCHC domain containing 6”, is an enzyme that in humans is encoded by the ZCCHC6 gene located on chromosome 9.[5][6] The ZCCHC6 protein mediates the terminal uridylation of RNA transcripts with short poly-A tails and is involved in mRNA and microRNA degradation       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsStructure[edit]Function[edit]References[edit]Further reading[edit]Structure[edit]The ZCCHC6 gene contains 33 exons with at least six known isoforms due to alternative splicing. The ZCCHC6 gene encodes for a protein that is 171 kDa in molecular weight and is localized to the cytoplasm.Function[edit]It catalyzes the following reaction, requiring Mg2+ and Mn2+ as co-factors.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4UTP + RNA(n) = diphosphate + RNA(n+1) [7]Uridylation catalyzed by ZCCHC6 takes place readily on deadenylated mRNAs inside the cells.[8] Purified ZZHC6 selectively recognizes and uridylates RNA molecules possessing short poly(A) tails (less than 25 nucleotides) in vitro.  In cells depleted of ZCCHC6, the majority of mRNAs lose the signature oligo(U) tails that are characteristic of ZCCHC6 reactivity, and the half-life of mRNA molecules are accordingly prolonged.[8]In addition to mRNA degradation, uridylation is also thought to function in pre-microRNA maturation, with some group II pre-microRNA requiring 3′ mono-uridylation for Dicer processing.[9] ZCCHC6 is thought to work in redundancy with ZCCHC11 to mediate the biogenesis of the let-7 microRNA through uridylation.[10]References[edit]^ a b c GRCh38: Ensembl release 89: ENSG00000083223 – Ensembl, May 2017^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035248 – Ensembl, May 2017^ “Human PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ “Mouse PubMed Reference:”. National Center for Biotechnology Information, U.S. National Library of Medicine.^ Nagase T, Kikuno R, Hattori A, Kondo Y, Okumura K, Ohara O (Dec 2000). “Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro”. DNA Research. 7 (6): 347\u201355. doi:10.1093\/dnares\/7.6.347. PMID\u00a011214970.^ “Entrez Gene: ZCCHC6 zinc finger, CCHC domain containing 6”.^ Rissland OS, Mikulasova A, Norbury CJ (2007). “Efficient RNA polyuridylation by noncanonical poly(A) polymerases”. Mol. Cell. Biol. 27 (10): 3612\u201324. doi:10.1128\/MCB.02209-06. PMC\u00a01899984. PMID\u00a017353264.^ a b Lim J, Ha M, Chang H, Kwon SC, Simanshu DK, Patel DJ, Kim VN (2014). “Uridylation by TUT4 and TUT7 marks mRNA for degradation”. Cell. 159 (6): 1365\u201376. doi:10.1016\/j.cell.2014.10.055. PMC\u00a04720960. PMID\u00a025480299.^ Heo I, Ha M, Lim J, Yoon MJ, Park JE, Kwon SC, Chang H, Kim VN (2012). “Mono-uridylation of pre-microRNA as a key step in the biogenesis of group II let-7 microRNAs”. Cell. 151 (3): 521\u201332. doi:10.1016\/j.cell.2012.09.022. PMID\u00a023063654.^ Thornton JE, Chang HM, Piskounova E, Gregory RI (2012). “Lin28-mediated control of let-7 microRNA expression by alternative TUTases Zcchc11 (TUT4) and Zcchc6 (TUT7)”. RNA. 18 (10): 1875\u201385. doi:10.1261\/rna.034538.112. PMC\u00a03446710. PMID\u00a022898984.Further reading[edit]Hartley JL, Temple GF, Brasch MA (Nov 2000). “DNA cloning using in vitro site-specific recombination”. Genome Research. 10 (11): 1788\u201395. doi:10.1101\/gr.143000. PMC\u00a0310948. PMID\u00a011076863.Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, B\u00f6cher M, Bl\u00f6cker H, Bauersachs S, Blum H, Lauber J, D\u00fcsterh\u00f6ft A, Beyer A, K\u00f6hrer K, Strack N, Mewes HW, Ottenw\u00e4lder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). “Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs”. Genome Research. 11 (3): 422\u201335. doi:10.1101\/gr.GR1547R. PMC\u00a0311072. PMID\u00a011230166.Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, Bechtel S, Sauermann M, Korf U, Pepperkok R, S\u00fcltmann H, Poustka A (Oct 2004). “From ORFeome to biology: a functional genomics pipeline”. Genome Research. 14 (10B): 2136\u201344. doi:10.1101\/gr.2576704. PMC\u00a0528930. PMID\u00a015489336.Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, Bechtel S, Simpson J, Hofmann O, Hide W, Glatting KH, Huber W, Pepperkok R, Poustka A, Wiemann S (Jan 2006). “The LIFEdb database in 2006”. Nucleic Acids Research. 34 (Database issue): D415\u20138. doi:10.1093\/nar\/gkj139. PMC\u00a01347501. PMID\u00a016381901.       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki24\/zcchc6-wikipedia\/#breadcrumbitem","name":"ZCCHC6 – Wikipedia"}}]}]