[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki4\/mir-124-microrna-precursor-family-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki4\/mir-124-microrna-precursor-family-wikipedia\/","headline":"mir-124 microRNA precursor family – Wikipedia","name":"mir-124 microRNA precursor family – Wikipedia","description":"before-content-x4 From Wikipedia, the free encyclopedia after-content-x4 The miR-124 microRNA precursor is a small non-coding RNA molecule that has been","datePublished":"2022-09-26","dateModified":"2022-09-26","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki4\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki4\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki4\/mir-124-microrna-precursor-family-wikipedia\/","wordCount":2876,"articleBody":"     (adsbygoogle = window.adsbygoogle || []).push({});before-content-x4From Wikipedia, the free encyclopedia       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4The miR-124 microRNA precursor is a small non-coding RNA molecule that has been identified in flies (MI0000373),[1]nematode worms (MI0000302),[2] mouse (MI0000150) and human (MI0000443).[3]  The mature ~21 nucleotide microRNAs are processed from hairpin precursor sequences by the Dicer enzyme, and in this case originates from the 3′ arm. miR-124 has been found to be the most abundant microRNA expressed in neuronal cells. Experiments to alter expression of miR-124 in neural cells did not appear to affect differentiation.[4] However these results are controversial since other reports have described a role for miR-124 during neuronal differentiation.[5]       (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4Table of ContentsTargets of miR-124[edit]Clinical medicine[edit]References[edit]External links[edit]Targets of miR-124[edit]Visvanathan et al. showed that miR-124 targets the mRNA of the anti-neural function protein SCP1 (small C-terminal domain phosphatase 1).[6]Makeyev et al. showed that miR-124 directly targets PTBP1 (PTB\/hnRNP I) mRNA, which encodes a global repressor of alternative pre-mRNA splicing in non-neuronal cells.[7]Arrant et al. wrote that miR-124 changes glutamate receptor composition in the prefrontal cortex and can decrease social dysfunction in frontotemporal dementia.[8]Clinical medicine[edit]Presence of the G allele, compared to the C allele, in SNP rs531564 in pri-miR-124-1, measured by PCR-RFLP in leukocyte DNA, is linked to a reduced risk of gastric cancer (e.g. GG v CC OR 0.34 95% CI 0.19-0.59, p     (adsbygoogle = window.adsbygoogle || []).push({});after-content-x4"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki4\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki4\/mir-124-microrna-precursor-family-wikipedia\/#breadcrumbitem","name":"mir-124 microRNA precursor family – Wikipedia"}}]}]