[{"@context":"http:\/\/schema.org\/","@type":"BlogPosting","@id":"https:\/\/wiki.edu.vn\/en\/wiki40\/glycoside-hydrolase-family-36-wikipedia\/#BlogPosting","mainEntityOfPage":"https:\/\/wiki.edu.vn\/en\/wiki40\/glycoside-hydrolase-family-36-wikipedia\/","headline":"Glycoside hydrolase family 36 – Wikipedia","name":"Glycoside hydrolase family 36 – Wikipedia","description":"From Wikipedia, the free encyclopedia In molecular biology, glycoside hydrolase family 36 is a family of glycoside hydrolases. Glycoside hydrolases","datePublished":"2016-04-04","dateModified":"2016-04-04","author":{"@type":"Person","@id":"https:\/\/wiki.edu.vn\/en\/wiki40\/author\/lordneo\/#Person","name":"lordneo","url":"https:\/\/wiki.edu.vn\/en\/wiki40\/author\/lordneo\/","image":{"@type":"ImageObject","@id":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/c9645c498c9701c88b89b8537773dd7c?s=96&d=mm&r=g","height":96,"width":96}},"publisher":{"@type":"Organization","name":"Enzyklop\u00e4die","logo":{"@type":"ImageObject","@id":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","url":"https:\/\/wiki.edu.vn\/wiki4\/wp-content\/uploads\/2023\/08\/download.jpg","width":600,"height":60}},"image":{"@type":"ImageObject","@id":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","url":"https:\/\/en.wikipedia.org\/wiki\/Special:CentralAutoLogin\/start?type=1x1","height":"1","width":"1"},"url":"https:\/\/wiki.edu.vn\/en\/wiki40\/glycoside-hydrolase-family-36-wikipedia\/","about":["Wiki"],"wordCount":3276,"articleBody":"From Wikipedia, the free encyclopediaIn molecular biology, glycoside hydrolase family 36 is a family of glycoside hydrolases.Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy web site,[4][5] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes.[6][7]Glycoside hydrolase family 36 together with family 31 and family 27 alpha-galactosidases form the glycosyl hydrolase clan GH-D, a superfamily of alpha-galactosidases, alpha-N-acetylgalactosaminidases, and isomaltodextranases which are likely to share a common catalytic mechanism and structural topology.Alpha-galactosidase (EC 3.2.1.22) (melibiase)[8] catalyzes the hydrolysis of melibiose into galactose and glucose. In man, the deficiency of this enzyme is the cause of Fabry’s disease (X-linked sphingolipidosis). Alpha-galactosidase is present in a variety of organisms. There is a considerable degree of similarity in the sequence of alpha-galactosidase from various eukaryotic species. Escherichia coli alpha-galactosidase (gene melA), which requires NAD and magnesium as cofactors, is not structurally related to the eukaryotic enzymes; by contrast, an Escherichia coli plasmid encoded alpha-galactosidase (gene rafA P16551)[9] contains a region of about 50 amino acids which is similar to a domain of the eukaryotic alpha-galactosidases. Alpha-N-acetylgalactosaminidase (EC 3.2.1.49)[10] catalyzes the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D- galactosaminides. In man, the deficiency of this enzyme is the cause of Schindler and Kanzaki diseases. The sequence of this enzyme is highly related to that of the eukaryotic alpha-galactosidases.This family also includes raffinose synthase proteins, also known as seed inhibition (Sip1) proteins. Raffinose (O-alpha- D-galactopyranosyl- (1–>6)- O-alpha- D-glucopyranosyl-(12)- O-beta- D-fructofuranoside) is a widespread oligosaccharide in plant seeds and other tissues. Raffinose synthase EC 2.4.1.82 is the key enzyme that channels sucrose into the raffinose oligosaccharide pathway.[11]Glycoside hydrolase family 36 also includes enzymes with \u03b1-N-acetylgalactosaminidase EC 3.2.1.49  and stachyose synthase EC 2.4.1.67 activities.Glycoside hydrolase family 36 can be subdivided into 11 families, GH36A to GH36K.[12]References[edit]^ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). “Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases”. Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090\u20137094. Bibcode:1995PNAS…92.7090H. doi:10.1073\/pnas.92.15.7090. PMC\u00a041477. PMID\u00a07624375.^ Henrissat B, Davies G (1995). “Structures and mechanisms of glycosyl hydrolases”. Structure. 3 (9): 853\u2013859. doi:10.1016\/S0969-2126(01)00220-9. PMID\u00a08535779.^ “Bairoch, A. “Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT”. 1999″. Archived from the original on 2011-05-25. Retrieved 2011-11-08.^ “Home”. CAZy.org. Retrieved 2018-03-06.^ Lombard, Vincent; Golaconda Ramulu, Hemalatha; Drula, Elodie; Coutinho, Pedro M.; Henrissat, Bernard (2014-01-01). “The carbohydrate-active enzymes database (CAZy) in 2013”. Nucleic Acids Research. 42 (D1): D490\u2013D495. doi:10.1093\/nar\/gkt1178. ISSN\u00a00305-1048. PMC\u00a03965031. PMID\u00a024270786.^ “Glycoside Hydrolase Family 36”. CAZypedia.org. Retrieved 2018-03-06.^ CAZypedia Consortium (2018-12-01). “Ten years of CAZypedia: a living encyclopedia of carbohydrate-active enzymes” (PDF). Glycobiology. 28 (1): 3\u20138. doi:10.1093\/glycob\/cwx089. ISSN\u00a01460-2423. PMID\u00a029040563.^ Dey PM, Pridham JB (1972). “Biochemistry of -galactosidases”. Adv. Enzymol. Relat. Areas Mol. Biol. 36: 91\u2013120. doi:10.1002\/9780470122815.ch3. PMID\u00a04561015.^ Aslanidis C, Schmid K, Schmitt R (1989). “Nucleotide sequences and operon structure of plasmid-borne genes mediating uptake and utilization of raffinose in Escherichia coli”. J. Bacteriol. 171 (12): 6753\u20136763. doi:10.1128\/jb.171.12.6753-6763.1989. PMC\u00a0210573. PMID\u00a02556373.^ Wang AM, Bishop DF, Desnick RJ (1990). “Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Homology with human alpha-galactosidase A suggests evolution from a common ancestral gene”. J. Biol. Chem. 265 (35): 21859\u201321866. doi:10.1016\/S0021-9258(18)45818-8. PMID\u00a02174888.^ Peterbauer T, Mach L, Mucha J, Richter A (September 2002). “Functional expression of a cDNA encoding pea (Pisum sativum L.) raffinose synthase, partial purification of the enzyme from maturing seeds, and steady-state kinetic analysis of raffinose synthesis”. Planta. 215 (5): 839\u201346. doi:10.1007\/s00425-002-0804-7. PMID\u00a012244450. S2CID\u00a0449826.^ Naumoff DG (2011). “Hierarchical classification of glycoside hydrolases”. Biochemistry (Moscow). 76 (6): 622\u201335. doi:10.1134\/S0006297911060022. PMID\u00a021639842. S2CID\u00a0206838603.External links[edit]External links[edit]"},{"@context":"http:\/\/schema.org\/","@type":"BreadcrumbList","itemListElement":[{"@type":"ListItem","position":1,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki40\/#breadcrumbitem","name":"Enzyklop\u00e4die"}},{"@type":"ListItem","position":2,"item":{"@id":"https:\/\/wiki.edu.vn\/en\/wiki40\/glycoside-hydrolase-family-36-wikipedia\/#breadcrumbitem","name":"Glycoside hydrolase family 36 – Wikipedia"}}]}]